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Protein Domain : IPR015429

Name  Cyclin C/H/T/L Short Name  Cyclin_C/H/T/L
Type  Family Description  Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2(Herpesvirus saimiri) and Human herpesvirus 8(HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].The cyclins in this entry are involved in the regulation of RNA polymerase II transcription []. They include cyclins belonging to the C/H/T/L types.

Publication Counts Displayer

8 Child Features

DB identifier Name Short Name Type
IPR023598 Cyclin C CyclinC Family
IPR017060 Cyclin L Cyclin_L Family
IPR027081 CyclinH/Ccl1 CyclinH/Ccl1 Family
IPR028759 Cyclin-related protein FAM58 Cyclin-rel_FAM58 Family
IPR015430 Cyclin T Cyclin_T Family
IPR028367 RNA polymerase II holoenzyme, cyclin-like subunit Ssn8, fungi Cyclin-like_Ssn8 Family
IPR028862 Cyclin-T2 CCNT2 Family
IPR028863 Cyclin-T1 CCNT1 Family

2 Contains

DB identifier Name Short Name Type
IPR013763 Cyclin-like Cyclin-like Domain
IPR006671 Cyclin, N-terminal Cyclin_N Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR10026 PANTHER IPR015429

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Cyclin C/H/T/L   GO:0019901 protein kinase binding
Cyclin C/H/T/L   GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
Cyclin C/H/T/L   GO:0006355 regulation of transcription, DNA-templated

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Cyclin C/H/T/L   GO:0019901 protein kinase binding
Cyclin C/H/T/L   GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
Cyclin C/H/T/L   GO:0006355 regulation of transcription, DNA-templated

0 Parent Features

77 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0070418 Q9W526 Drosophila melanogaster
FBpp0089275 M9PI89 Drosophila melanogaster
FBpp0074968 O96433 Drosophila melanogaster
FBpp0310472 Q961D1 Drosophila melanogaster
FBpp0078093 O76513 Drosophila melanogaster
FBpp0082469 P25008 Drosophila melanogaster
FBpp0306264 Q9VE72 Drosophila melanogaster
FBpp0297955 Q299M1 Drosophila pseudoobscura
FBpp0274484 Q2M0B7 Drosophila pseudoobscura
FBpp0274646 Q2M0U3 Drosophila pseudoobscura
FBpp0282452 Q29AI1 Drosophila pseudoobscura
FBpp0285349 Q29I19 Drosophila pseudoobscura
FBpp0285825 Q29JQ2 Drosophila pseudoobscura
FBpp0160784 B4KUV3 Drosophila mojavensis
FBpp0162174 B4KZJ7 Drosophila mojavensis
FBpp0166711 B4KFW1 Drosophila mojavensis
FBpp0167767 B4KRI4 Drosophila mojavensis
FBpp0170818 B4L532 Drosophila mojavensis
FBpp0173490 B4K946 Drosophila mojavensis
FBpp0225263 B4M412 Drosophila virilis
FBpp0225663 B4LCT9 Drosophila virilis
FBpp0227517 B4LEZ8 Drosophila virilis
FBpp0229571 B4LQT2 Drosophila virilis
FBpp0230958 B4M706 Drosophila virilis
FBpp0234761 B4LQ75 Drosophila virilis
FBpp0257978 B4P6D7 Drosophila yakuba
FBpp0261988 B4Q1B4 Drosophila yakuba
FBpp0264804 B4ITC1 Drosophila yakuba
FBpp0267146 B4PJL4 Drosophila yakuba
FBpp0271434 B4PSN5 Drosophila yakuba