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Protein Domain : IPR011993

Name  Pleckstrin homology-like domain Short Name  PH_like_dom
Type  Domain Description  Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of signalling proteins, where they serve as simple targeting domains that bind lipids [, , ]. PH domains have a partly opened beta-barrel topology that is capped by an alpha helix. The structure of PH domains is similar to the phosphotyrosine-binding domain (PTB) found in IRS-1 (insulin receptor substrate 1), Shc adaptor and Numb; to the Ran-binding domain, found in Nup nuclear pore complex and Ranbp1; to the Enabled/VASP homology domain 1 (EVH1 domain), found in Enabled, VASP (vasodilator-stimulated phosphoprotein), Homer and WASP actin regulatory protein; to the third domain of FERM, found in moesin, radixin, ezrin, merlin and talin; and to the PH-like domain of neurobeachin.This entry recognises PH domains and other structurally related domains.

Publication Counts Displayer

6 Child Features

DB identifier Name Short Name Type
IPR001849 Pleckstrin homology domain Pleckstrin_homology Domain
IPR000697 WH1/EVH1 WH1/EVH1 Domain
IPR002404 Insulin receptor substrate-1, PTB Insln_rcpt_S1 Domain
IPR006020 PTB/PI domain PTB/PI_dom Domain
IPR018980 FERM, C-terminal PH-like domain FERM_PH-like_C Domain
IPR000156 Ran binding domain Ran_bind_dom Domain

2 Contains

DB identifier Name Short Name Type
IPR013625 Tensin phosphotyrosine-binding domain PTB Domain
IPR001562 Zinc finger, Btk motif Znf_Btk_motif Conserved_site

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
G3DSA:2.30.29.30 GENE3D IPR011993

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

16 Found In

DB identifier Name Short Name Type
IPR015727 Protein kinase C mu-related Protein_Kinase_C_mu-related Family
IPR000299 FERM domain FERM_domain Domain
IPR012151 Protein-tyrosine phosphatase, non-receptor type-3, -4 Tyr_Pase_non-rcpt_typ-3/4 Family
IPR011174 Ezrin/radixin/moesin ERM Family
IPR000798 Ezrin/radixin/moesin like Ez/rad/moesin_like Family
IPR015788 Moesin/ezrin/radixin homologue 2 EMR2 Family
IPR015767 Rho GTPase activating protein Rho_GTPase_act Family
IPR016343 Spectrin, beta subunit Spectrin_bsu Family
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma PLC-gamma Family
IPR021187 Band 4.1 protein Band_41_protein Family
IPR014392 Protein-tyrosine phosphatase, non-receptor type-14, -21 Tyr_Pase_non-rcpt_typ-14/21 Family
IPR012153 Protein-tyrosine phosphatase, non-receptor type-13 Tyr_Pase_non-rcpt_typ-13 Family
IPR015710 Talin-1 Talin-1 Family
IPR015711 Talin-2 Talin-2 Family
IPR017405 Citron Rho-interacting kinase Citron_Rho-interacting_kinase Family
IPR016609 Uncharacterised conserved protein UCP013217, Opy1p UCP013217_Opy1 Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

1487 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086123 A1ZAN7 Drosophila melanogaster
FBpp0086124 A1ZAN6 Drosophila melanogaster
FBpp0075035 Q9VVD2 Drosophila melanogaster
FBpp0081553 Q9VHA6 Drosophila melanogaster
FBpp0084350 Q9VBI4 Drosophila melanogaster
FBpp0084351 Q7KRZ3 Drosophila melanogaster
FBpp0089147 Q8IR23 Drosophila melanogaster
FBpp0077948 Q7KTX2 Drosophila melanogaster
FBpp0290817 E1JI59 Drosophila melanogaster
FBpp0290812 E1JJA5 Drosophila melanogaster
FBpp0290862 Q9W1H5 Drosophila melanogaster
FBpp0080123 Q9NGC3 Drosophila melanogaster
FBpp0112066 A8JNN5 Drosophila melanogaster
FBpp0076332 Q9VSI2 Drosophila melanogaster
FBpp0076096 P48423 Drosophila melanogaster
FBpp0303201 M9PF62 Drosophila melanogaster
FBpp0307725 M9PBE8 Drosophila melanogaster
FBpp0307723 A8DZ19 Drosophila melanogaster
FBpp0111798 A8DZ20 Drosophila melanogaster
FBpp0307724 M9PGB1 Drosophila melanogaster
FBpp0291316 C3KGL5 Drosophila melanogaster
FBpp0080888 Q9VIN1 Drosophila melanogaster
FBpp0305901 M9PHJ6 Drosophila melanogaster
FBpp0074448 Q9NHV9 Drosophila melanogaster
FBpp0112228 A8JUQ9 Drosophila melanogaster
FBpp0075702 Q9VTY8 Drosophila melanogaster
FBpp0083010 Q9VE91 Drosophila melanogaster
FBpp0077947 Q9VP80 Drosophila melanogaster
FBpp0290810 P27619 Drosophila melanogaster
FBpp0082261 Q9VFU8 Drosophila melanogaster