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Protein Domain : IPR008985

Name  Concanavalin A-like lectin/glucanases superfamily Short Name  ConA-like_lec_gl_sf
Type  Domain Description  Lectins and glucanases exhibit the common property of reversibly binding to specific complex carbohydrates. The lectins/glucanases are a diverse group of proteins found in a wide range of species from prokaryotes to humans. The different family members all contain a concanavalin A-like domain, which consists of a sandwich of 12-14 beta strands in two sheets with a complex topology. Members of this family are diverse, and include the lectins: legume lectins, cereal lectins, viral lectins, and animal lectins. Plant lectins function in the storage and transport of carbohydrates in seeds, the binding of nitrogen-fixing bacteria to root hairs, the inhibition of fungal growth or insect feeding, and in hormonally regulated plant growth []. Protein members include concanavalin A (Con A), favin, isolectin I, lectin IV, soybean agglutinin and lentil lectin. Animal lectins include the galectins, which are S-type lactose-binding and IgE-binding proteins such as S-lectin, CLC protein, galectin1, galectin2, galectin3 CRD, and Congerin I []. Other members with a Con A-like domain include the glucanases and xylanases. Bacterial and fungal beta-glucanases, such as Bacillus 1-3,1-4-beta-glucanse, carry out the acid catalysis of beta-glucans found in microorganisms and plants []. Similarly, kappa-Carrageenase degrades kappa-carrageenans from marine red algae cell walls []. Xylanase and cellobiohydrolase I degrade hemicellulose and cellulose, respectively [, ]. There are many Con A-like domains found in proteins involved in cell recognition and adhesion. For example, several viral and bacterial toxins carry Con A-like domains. Examples include the Clostridium neurotoxins responsible for the neuroparalytic effects of botulism and tetanus []. The Pseudomonas exotoxin A, a virulence factor which is highly toxic to eukaryotic cells, causing the arrest of protein synthesis, contains a Con A-like domain involved in receptor binding []. Cholerae neuraminidase can bind to cell surfaces, possibly through their Con A-like domains, where they function as part of a mucinase complex to degrade the mucin layer of the gastrointestinal tract []. The rotaviral outer capsid protein, VP4, has a Con A-like sialic acid binding domain, which functions in cell attachment and membrane penetration [].Con A-like domains also play a role in cell recognition in eukaryotes. Proteins containing a Con A-like domain include the sex hormone-binding globulins which transport sex steroids in blood and regulate their access to target tissues [], laminins which are large heterotrimeric glycoproteins involved in basement membrane architecture and function [], neurexins which are expressed in hundreds of isoforms on the neuronal cell surface, where they may function as cell recognition molecules []and sialidases that are found in both microorganisms and animals, and function in cell adhesion and signal transduction []. Other proteins containing a Con A-like domain include pentraxins and calnexins. The pentraxin PTX3 is a TNFalpha-induced, secreted protein of adipose cells produced during inflammation []. The calnexin family of molecular chaperones is conserved among plants, fungi, and animals. Family members include Calnexin, a type-I integral membrane protein in the endoplasmic reticulum which coordinates the processing of newly synthesized N-linked glycoproteins with their productive folding, calmegin, a type-I membrane protein expressed mainly in the spermatids of the testis, and calreticulin, a soluble ER lumenal paralog [].

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR013189 Glycosyl hydrolase family 32, C-terminal Glyco_hydro_32_C Domain

8 Contains

DB identifier Name Short Name Type
IPR018124 Calreticulin/calnexin, conserved site Calret/calnex_CS Conserved_site
IPR015344 Vibrio cholerae neuraminidase, lectin-like domain VCNA_lectin-like_dom Domain
IPR019825 Legume lectin, beta chain, Mn/Ca-binding site Lectin_legB_Mn/Ca_BS Binding_site
IPR018208 Glycoside hydrolase, family 11, active site Glyco_hydro_11_AS Active_site
IPR000985 Legume lectin, alpha chain, conserved site Lectin_LegA_CS Conserved_site
IPR010713 Xyloglucan endo-transglycosylase, C-terminal XET_C Domain
IPR008263 Glycoside hydrolase, family 16, active site Glycoside_hydrolase_16_AS Active_site
IPR006558 LamG-like jellyroll fold LamG-like Domain

1 Cross References

Source . Name

Subject . Primary Identifier
SSF49899 SSF IPR008985

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

3 Found In

DB identifier Name Short Name Type
IPR017229 Multidomain scavenger receptor-like protein PxSR Scavenger_rcpt_PxSR Family
IPR001722 Glycoside hydrolase, family 7 Glyco_hydro_7 Family
IPR000250 Peptidase G1 Peptidase_G1 Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

900 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0293057 M9MRI4 Drosophila melanogaster
FBpp0079685 Q86P21 Drosophila melanogaster
FBpp0291871 Q8IP51 Drosophila melanogaster
FBpp0293600 R9PY40 Drosophila melanogaster
FBpp0291872 M9MRU0 Drosophila melanogaster
FBpp0099719 Q4ABE9 Drosophila melanogaster
FBpp0099718 Q4ABF0 Drosophila melanogaster
FBpp0080568 O15943 Drosophila melanogaster
FBpp0099721 Q4ABE7 Drosophila melanogaster
FBpp0099720 Q4ABE8 Drosophila melanogaster
FBpp0288558 Q9VM55 Drosophila melanogaster
FBpp0291372 E1JHA6 Drosophila melanogaster
FBpp0086875 Q9V6L9 Drosophila melanogaster
FBpp0310997 B7Z0X3 Drosophila melanogaster
FBpp0310995 B7Z0W8 Drosophila melanogaster
FBpp0310994 Q0KHV9 Drosophila melanogaster
FBpp0075730 Q94887 Drosophila melanogaster
FBpp0076352 Q9V3A8 Drosophila melanogaster
FBpp0076237 Q9NHA8 Drosophila melanogaster
FBpp0074074 Q9VXF6 Drosophila melanogaster
FBpp0298310 M9MRV7 Drosophila melanogaster
FBpp0298312 M9NE09 Drosophila melanogaster
FBpp0298311 Q9VZG5 Drosophila melanogaster
FBpp0305853 L0MQ08 Drosophila melanogaster
FBpp0088271 Q9V498 Drosophila melanogaster
FBpp0074861 Q9VVR4 Drosophila melanogaster
FBpp0085887 A1ZBB1 Drosophila melanogaster
FBpp0086264 Q7KJ08 Drosophila melanogaster
FBpp0077156 Q9V3H7 Drosophila melanogaster
FBpp0077167 P33450 Drosophila melanogaster