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Protein Domain : IPR001841

Name  Zinc finger, RING-type Short Name  Znf_RING
Type  Domain Description  Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis(African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. This entry represents RING-type zinc finger domains. The RING-finger is a specialised type of Zn-finger of 40 to 60 residues that binds two atoms of zinc, and is probably involved in mediating protein-protein interactions [, , ]. There are two different variants, the C3HC4-type and a C3H2C3-type, which are clearly related despite the different cysteine/histidine pattern. The latter type is sometimes referred to as 'RING-H2 finger'. The RING domain is a protein interaction domain that has been implicated in a range of diverse biological processes. E3 ubiquitin-protein ligase activity is intrinsic to the RING domain of c-Cbl and is likely to be a general function of this domain. E3 ubiquitin-protein ligases determine the substrate specificity for ubiquitylation and have been classified into HECT and RING-finger families. More recently, however, U-box proteins, which contain a domain (the U box) of about 70 amino acids that is conserved from yeast to humans, have been identified as a new type of E3 []. Various RING fingers also exhibit binding to E2 ubiquitin-conjugating enzymes (Ubc's) [, , ].Several 3D-structures for RING-fingers are known [, ]. The 3D structure of the zinc ligation system is unique to the RING domain and is referred to as the 'cross-brace' motif. The spacing of the cysteines in such a domain is C-x(2)-C-x(9 to 39)-C-x(1 to 3)-H-x(2 to 3)-C-x(2)-C-x(4 to 48)-C-x(2)-C. Metal ligand pairs one and three co-ordinate to bind one zinc ion, whilst pairs two and four bind the second.Note that in the older literature, some RING-fingers are denoted as LIM-domains. The LIM-domain Zn-finger is a fundamentally different family, albeit with similar Cys-spacing (see ).

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR024766 Zinc finger, RING-H2-type Znf_RING_H2 Domain
IPR027934 Cellulose synthase, RING-type zinc finger CES_Znf_RING Domain

1 Contains

DB identifier Name Short Name Type
IPR017907 Zinc finger, RING-type, conserved site Znf_RING_CS Conserved_site

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF13639 PFAM IPR001841
PF14634 PFAM IPR001841
PS50089 PROFILE IPR001841
SM00184 SMART IPR001841

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

18 Found In

DB identifier Name Short Name Type
IPR004162 E3 ubiquitin-protein ligase SINA like SINA_like Family
IPR016902 Vacuolar protein sorting-associated protein 41 VPS41 Family
IPR012227 TNF receptor-associated factor TRAF TNF_rcpt--assoc_TRAF Family
IPR017375 Peroxisome assembly protein 12 PEX12 Family
IPR004575 Cdk-activating kinase assembly factor MAT1/Tfb3 MAT1/Tfb3 Family
IPR001237 43kDa postsynaptic protein Postsynaptic Family
IPR016818 Nitric oxide synthase-interacting Nitric_oxide_synth-interacting Family
IPR016528 Vacuolar protein sorting-associated protein 11 VPS11 Family
IPR016569 Methyltransferase, trithorax MeTrfase_trithorax Family
IPR011364 Breast cancer type 1 susceptibility protein (BRCA1) BRCA1 Family
IPR015458 MDM4 MDM4 Family
IPR016495 p53 negative regulator Mdm2/Mdm4 p53_neg-reg_MDM_2/4 Family
IPR015459 Ubiquitin-protein ligase E3 MDM2 MDM2_E3_ligase Family
IPR004580 DNA repair protein, Rad18 Rad18 Family
IPR016398 E3 ubiquitin-protein ligase p28 E3_ubiquitin-prot_ligase_p28 Family
IPR017335 E3 ubiquitin ligase, RNF8 E3_Ub_ligase_RNF8 Family
IPR017066 S-ribonuclease binding protein, SBP1, pollen S-RNase-bd_SBP1_pollen Family
IPR007954 Baculovirus immediate-early Baculo_IE-1 Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Zinc finger, RING-type   GO:0005515 protein binding
Zinc finger, RING-type   GO:0008270 zinc ion binding

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Zinc finger, RING-type   GO:0005515 protein binding
Zinc finger, RING-type   GO:0008270 zinc ion binding

1 Parent Features

DB identifier Name Short Name Type
IPR013083 Zinc finger, RING/FYVE/PHD-type Znf_RING/FYVE/PHD Domain

2223 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0073674 Q9VY98 Drosophila melanogaster
FBpp0303663 M9PCD7 Drosophila melanogaster
FBpp0303658 Q8IPJ3 Drosophila melanogaster
FBpp0303660 M9PB55 Drosophila melanogaster
FBpp0303662 M9PCS0 Drosophila melanogaster
FBpp0293057 M9MRI4 Drosophila melanogaster
FBpp0079685 Q86P21 Drosophila melanogaster
FBpp0305727 Q9W5W9 Drosophila melanogaster
FBpp0080265 P40798 Drosophila melanogaster
FBpp0304749 M9PDG3 Drosophila melanogaster
FBpp0304750 M9PD57 Drosophila melanogaster
FBpp0073753 Q9VY20 Drosophila melanogaster
FBpp0073100 Q9VZF2 Drosophila melanogaster
FBpp0070458 Q9W4W4 Drosophila melanogaster
FBpp0082409 P20659 Drosophila melanogaster
FBpp0074688 O97159 Drosophila melanogaster
FBpp0304462 M9PIA6 Drosophila melanogaster
FBpp0099808 Q59E34 Drosophila melanogaster
FBpp0075181 Q9VV48 Drosophila melanogaster
FBpp0292193 S0ARU4 Drosophila melanogaster
FBpp0086906 P25172 Drosophila melanogaster
FBpp0080686 Q9VJ14 Drosophila melanogaster
FBpp0075275 Q9VUX2 Drosophila melanogaster
FBpp0294022 Q86B79 Drosophila melanogaster
FBpp0078288 Q8I0J6 Drosophila melanogaster
FBpp0078287 Q9VNJ0 Drosophila melanogaster
FBpp0075727 Q9VTT9 Drosophila melanogaster
FBpp0085754 Q9V8P9 Drosophila melanogaster
FBpp0089379 Q7KRW1 Drosophila melanogaster
FBpp0084798 A4V3L3 Drosophila melanogaster