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Protein Domain : IPR017986

Name  WD40-repeat-containing domain Short Name  WD40_repeat_dom
Type  Domain Description  WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed beta-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. Repeated WD40 motifs act as a site for protein-protein interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller), TAFII transcription factor, and E3 ubiquitin ligase [, ]. In Arabidopsis spp., several WD40-containing proteins act as key regulators of plant-specific developmental events.This entry identifies a domain containing adjacent WD repeats.

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier Name Short Name Type
IPR001680 WD40 repeat WD40_repeat Repeat
IPR019775 WD40 repeat, conserved site WD40_repeat_CS Conserved_site
IPR001632 G-protein, beta subunit Gprotein_B Domain

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS50294 PROFILE IPR017986
SSF50978 SSF IPR017986

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

13 Found In

DB identifier Name Short Name Type
IPR017399 WD repeat protein 23 WD_repeat_p23 Family
IPR016346 Guanine nucleotide-binding protein, beta subunit Guanine_nucleotide-bd_bsu Family
IPR017252 Dynein regulator LIS1 Dynein_regulator_LIS1 Family
IPR009146 Groucho/transducin-like enhancer Groucho_enhance Family
IPR004083 Regulatory associated protein of TOR Raptor Family
IPR015505 Coronin Coronin Family
IPR017233 WD repeat protein 35 WD_repeat_p35 Family
IPR016391 Coatomer alpha subunit Coatomer_asu Family
IPR017383 ARP2/3 complex, 41kDa subunit (p41-arc) ARPC2/3_su1 Family
IPR016453 Coatomer beta' subunit (COPB2) COPB2 Family
IPR017422 WD repeat protein 55 WD_repeat_p55 Family
IPR017251 Apoptotic protease-activating factor 1 Apoptotic_pept-activating_1 Family
IPR017149 Glutathione degradosome, DUG2 GSH_degradosome_DUG2 Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
WD40-repeat-containing domain   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
WD40-repeat-containing domain   GO:0005515 protein binding

1 Parent Features

DB identifier Name Short Name Type
IPR015943 WD40/YVTN repeat-like-containing domain WD40/YVTN_repeat-like_dom Domain

2135 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0079266 Q9VLN1 Drosophila melanogaster
FBpp0086122 Q7KLI1 Drosophila melanogaster
FBpp0080048 O62621 Drosophila melanogaster
FBpp0070382 Q9W4Z9 Drosophila melanogaster
FBpp0070925 Q9W3W1 Drosophila melanogaster
FBpp0077778 Q9VPL0 Drosophila melanogaster
FBpp0078775 Q9VML2 Drosophila melanogaster
FBpp0088423 E6PBX0 Drosophila melanogaster
FBpp0073920 P26308 Drosophila melanogaster
FBpp0072437 Q8T0V3 Drosophila melanogaster
FBpp0072438 Q9W0U9 Drosophila melanogaster
FBpp0293022 Q9W060 Drosophila melanogaster
FBpp0271836 Q9VSN7 Drosophila melanogaster
FBpp0085527 Q7JVY0 Drosophila melanogaster
FBpp0304907 Q9W040 Drosophila melanogaster
FBpp0087323 A1Z8D0 Drosophila melanogaster
FBpp0086732 Q494K2 Drosophila melanogaster
FBpp0310997 B7Z0X3 Drosophila melanogaster
FBpp0310995 B7Z0W8 Drosophila melanogaster
FBpp0310994 Q0KHV9 Drosophila melanogaster
FBpp0080879 Q9VIP8 Drosophila melanogaster
FBpp0071222 Q9W395 Drosophila melanogaster
FBpp0081350 Q9VHT2 Drosophila melanogaster
FBpp0075597 Q9VU65 Drosophila melanogaster
FBpp0071450 Q8MSJ9 Drosophila melanogaster
FBpp0082998 Q9VE85 Drosophila melanogaster
FBpp0084187 Q9VBU8 Drosophila melanogaster
FBpp0075239 Q9VUZ6 Drosophila melanogaster
FBpp0085923 Q7K7W5 Drosophila melanogaster
FBpp0076386 Q9VSJ6 Drosophila melanogaster