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Protein Domain : IPR008974

Name  TRAF-like Short Name  TRAF-like
Type  Domain Description  The tumour necrosis factor receptor (TNFR) associated factors (TRAFs) act as signal transducers for both TNFRs and interleukin-1/Toll-like receptors. TRAFs function in immunity, embryonic development, stress response and bone metabolism through their induction of cell proliferation, differentiation, and apoptosis []. TRAFs are characterised by two domains: an N-terminal domain containing RING and zinc finger motifs that is essential for the activation of downstream effectors, and a C-terminal TRAF domain that is essential for self-association and receptor interaction []. The TRAF-domain like fold is a beta-sandwich consisting of 8 strands in 2 beta sheets and has a circularly permuted greek-key immunoglobulin-fold topology that contains an extra strand.The substrate-binding domain (SBD) of the SIAH (seven in absentia homolog) family of proteins is structurally highly similar to the TRAF domain. The SIAH SBD interacts with a number of proteins, and is involved in TNF-alpha-mediated NFkappaB activation [].

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR002083 MATH MATH Domain
IPR018121 Seven-in-absentia protein, TRAF-like domain 7-in-absentia-prot_TRAF-dom Domain

3 Contains

DB identifier Name Short Name Type
IPR013323 SIAH-type domain SIAH-type Domain
IPR013010 Zinc finger, SIAH-type Znf_SIAH Domain
IPR001293 Zinc finger, TRAF-type Znf_TRAF Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
SSF49599 SSF IPR008974

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR004162 E3 ubiquitin-protein ligase SINA like SINA_like Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
TRAF-like   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
TRAF-like   GO:0005515 protein binding

0 Parent Features

477 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0070458 Q9W4W4 Drosophila melanogaster
FBpp0073474 Q9VYQ8 Drosophila melanogaster
FBpp0075091 P21461 Drosophila melanogaster
FBpp0072874 Q9VZV5 Drosophila melanogaster
FBpp0080156 Q9VJW5 Drosophila melanogaster
FBpp0290846 C7LAF6 Drosophila melanogaster
FBpp0071136 Q9W3I9 Drosophila melanogaster
FBpp0099767 Q9VFP2 Drosophila melanogaster
FBpp0074051 Q8IR14 Drosophila melanogaster
FBpp0074050 Q9VXG5 Drosophila melanogaster
FBpp0074049 Q960H6 Drosophila melanogaster
FBpp0077119 Q9XYR0 Drosophila melanogaster
FBpp0290897 Q8T3Y0 Drosophila melanogaster
FBpp0075265 Q9VUV7 Drosophila melanogaster
FBpp0306504 A8DYU9 Drosophila melanogaster
FBpp0283924 Q298W3 Drosophila pseudoobscura
FBpp0291895 I5ANU6 Drosophila pseudoobscura
FBpp0291894 I5ANU5 Drosophila pseudoobscura
FBpp0275034 Q2M0J1 Drosophila pseudoobscura
FBpp0286472 Q29HR3 Drosophila pseudoobscura
FBpp0275155 B5DPK4 Drosophila pseudoobscura
FBpp0274243 Q29GI2 Drosophila pseudoobscura
FBpp0279066 B5DHC1 Drosophila pseudoobscura
FBpp0279320 Q29PB4 Drosophila pseudoobscura
FBpp0279527 Q29LI9 Drosophila pseudoobscura
FBpp0282681 Q29HD1 Drosophila pseudoobscura
FBpp0283353 Q29HL8 Drosophila pseudoobscura
FBpp0286277 Q29E32 Drosophila pseudoobscura
FBpp0286932 Q29DV1 Drosophila pseudoobscura
FBpp0286933 Q29DV0 Drosophila pseudoobscura