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Protein Domain : IPR016137

Name  Regulator of G protein signalling superfamily Short Name  Regulat_G_prot_signal_superfam
Type  Domain Description  This entry represents a structural domain with a multi-helical fold consisting of a 4-helical bundle with a left-handed twist and an up-and-down topology. This domain can be divided into two all-alpha subdomains. This domain is found in regulation of G-protein signalling (RGS) proteins, as well as other related proteins, including:RGS4 [].RGS9 [].G-alpha interacting protein GaIP [].Axin [].p115RhoGEF [].Pdz-RhoGEF [].G-protein coupled receptor kinase 2 N-terminal domain [].RGS (Regulator of G Protein Signalling) proteins are multi-functional, GTPase-accelerating proteins that promote GTP hydrolysis by the alpha subunit of heterotrimeric G proteins, thereby inactivating the G protein and rapidly switching off G protein-coupled receptor signalling pathways. Upon activation by GPCRs, heterotrimeric G proteins exchange GDP for GTP, are released from the receptor, and dissociate into free, active GTP-bound alpha subunit and beta-gamma dimer, both of which activate downstream effectors. The response is terminated upon GTP hydrolysis by the alpha subunit (), which can then bind the beta-gamma dimer (, ) and the receptor. RGS proteins markedly reduce the lifespan of GTP-bound alpha subunits by stabilising the G protein transition state.All RGS proteins contain an 'RGS-box' (or RGS domain), which is required for activity. Some small RGS proteins such as RGS1 and RGS4 are comprised of little more than an RGS domain, while others also contain additional domains that confer further functionality. RGS domains can be found inconjunction with a variety of domains, including: DEP for membrane targeting (), PDZ for binding to GPCRs (), PTB for phosphotyrosine-binding (), RBD for Ras-binding (), GoLoco for guanine nucleotide inhibitor activity (), PX for phosphatidylinositol-binding (), PXA that is associated with PX (), PH for stimulating guanine nucleotide exchange (), and GGL (G protein gamma subunit-like) for binding G protein beta subunits (). Those RGS proteins that contain GGL domains can interact with G protein beta subunits to form novel dimers that prevent G protein gamma subunit binding and G protein alpha subunit association, thereby preventing heterotrimer formation.

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR000342 Regulator of G protein signalling domain RGS_dom Domain
IPR015212 Regulator of G protein signalling-like domain RGS-like_dom Domain

0 Contains

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS50132 PROFILE IPR016137
SM00315 SMART IPR016137
SSF48097 SSF IPR016137

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

0 Found In

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Regulator of G protein signalling superfamily   GO:0038032 termination of G-protein coupled receptor signaling pathway

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Regulator of G protein signalling superfamily   GO:0038032 termination of G-protein coupled receptor signaling pathway

0 Parent Features

200 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086123 A1ZAN7 Drosophila melanogaster
FBpp0086124 A1ZAN6 Drosophila melanogaster
FBpp0080384 Q9V3I3 Drosophila melanogaster
FBpp0110413 P32865 Drosophila melanogaster
FBpp0085149 P32866 Drosophila melanogaster
FBpp0083669 Q8IN00 Drosophila melanogaster
FBpp0083668 Q9VCX2 Drosophila melanogaster
FBpp0083666 Q9VCX1 Drosophila melanogaster
FBpp0084919 Q9V407 Drosophila melanogaster
FBpp0084920 Q8IMJ7 Drosophila melanogaster
FBpp0071048 Q9W3N0 Drosophila melanogaster
FBpp0074124 Q9VXA3 Drosophila melanogaster
FBpp0290365 Q8T017 Drosophila melanogaster
FBpp0301188 D5A7N8 Drosophila melanogaster
FBpp0289827 E1JJ18 Drosophila melanogaster
FBpp0288469 B7Z0S0 Drosophila melanogaster
FBpp0289455 Q9VWP8 Drosophila melanogaster
FBpp0302026 M9PHI8 Drosophila melanogaster
FBpp0293919 I5AN25 Drosophila pseudoobscura
FBpp0293918 B5DYK9 Drosophila pseudoobscura
FBpp0293920 I5AN26 Drosophila pseudoobscura
FBpp0293917 I5AN24 Drosophila pseudoobscura
FBpp0283345 Q29BB5 Drosophila pseudoobscura
FBpp0272200 Q29FZ9 Drosophila pseudoobscura
FBpp0276614 B5E0Q5 Drosophila pseudoobscura
FBpp0278582 Q28XE9 Drosophila pseudoobscura
FBpp0283103 Q29C79 Drosophila pseudoobscura
FBpp0284953 Q29I26 Drosophila pseudoobscura
FBpp0285168 Q29NL7 Drosophila pseudoobscura
FBpp0285510 Q29FK8 Drosophila pseudoobscura