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Protein Domain : IPR016181

Name  Acyl-CoA N-acyltransferase Short Name  Acyl_CoA_acyltransferase
Type  Domain Description  This entry represents a structural domain found in several acyl-CoA acyltransferase enzymes. This domain has a 3-layer alpha/beta/alpha structure that contains mixed beta-sheets, and can be found in the following proteins:N-acetyl transferase (NAT) family members, including aminoglycoside N-acetyltransferases [], the histone acetyltransferase domain of P300/CBP associating factor PCAF [], the catalytic domain of GCN5 histone acetyltransferase [], and diamine acetyltransferase 1 [].Autoinducer synthetases, such as protein LasI []and acyl-homoserinelactone synthase EsaI [].Leucyl/phenylalanyl-tRNA-protein transferase (LFTR), a close relative of the non-ribosomal peptidyltransferases; there is a deletion of the N-terminal half of the N-terminal NAT-like domain after the domain duplication/swapping events [].Ornithine decarboxylase antizyme, which may have evolved a different function for this domain, although the putative active site maps to the same location in the common fold.Arginine N-succinyltransferase, alpha chain, AstA, which contains an extra C-terminal domain that is similar to the double psi beta-barrel fold domain (missing one strand and untangled psi-loops).Several proteins carry a duplication of this domain, which consists of two NAT-like domains swapped with the C-terminal strands, including:N-myristoyl transferase (NMT) [].FemXAB nonribosomal peptidyltransferases, including methicillin-resistance protein FemA (transfer glycyl residue from tRNA-Gly) []and peptidyltransferase FemX [].Hypothetical protein cg14615-pa from Drosophila melanogaster(Fruit fly).

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR000182 GNAT domain GNAT_dom Domain

11 Contains

DB identifier Name Short Name Type
IPR019467 Histone acetyl transferase HAT1 N-terminal Hat1_N Domain
IPR022677 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal MyristoylCoA_TrFase_C Domain
IPR022678 Myristoyl-CoA:protein N-myristoyltransferase, conserved site MyristoylCoA_TrFase_CS Conserved_site
IPR022676 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal MyristoylCoA_TrFase_N Domain
IPR002717 MOZ/SAS-like protein MOZ_SAS Domain
IPR009658 Domain of unknown function DUF1248 DUF1248 Domain
IPR013653 FR47-like FR47 Domain
IPR015938 Glycine N-acyltransferase, N-terminal Glycine_N-acyltransferase_N Domain
IPR013652 Glycine N-acyltransferase, C-terminal Glycine_N-acyltransferase_C Domain
IPR018311 Autoinducer synthesis, conserved site Autoind_synth_CS Conserved_site
IPR019432 Siderophore biosynthesis protein, conserved domain Siderophore_biosyn_cons_dom Domain

2 Cross References

Source . Name

Subject . Primary Identifier
G3DSA:3.40.630.30 GENE3D IPR016181
SSF55729 SSF IPR016181

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

11 Found In

DB identifier Name Short Name Type
IPR017380 Histone acetyltransferase type B, catalytic subunit Hist_AcTrfase_B-typ_cat-su Family
IPR000903 Myristoyl-CoA:protein N-myristoyltransferase MyristoylCoA_TrFase Family
IPR010313 Glycine N-acyltransferase Glycine_N-acyltransferase Family
IPR011242 N-acetylglutamate kinase, DUF619 domain-containing AcGlu_kinase_DUF619-contain Family
IPR007041 Arginine N-succinyltransferase Ast/AOST Arg_N-succinylTrfase_Ast/AOST Family
IPR017650 Arginine N-succinyltransferase AstA Arginine_N-succinylTrfase_AstA Family
IPR003447 Methicillin resistance protein Methicillin-R Family
IPR017469 PEP-CTERM system-associated, FemAB-related PEP-CTERM_FemAB-rel Family
IPR001690 Autoinducer synthesis protein Autoind_synth Domain
IPR010037 FkbH domain FkbH_domain Domain
IPR007434 Protein of unknown function DUF482 DUF482 Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

590 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0085627 O96539 Drosophila melanogaster
FBpp0080882 Q9VIQ1 Drosophila melanogaster
FBpp0099670 Q9VS50 Drosophila melanogaster
FBpp0304758 M9PI14 Drosophila melanogaster
FBpp0304759 Q9VWF5 Drosophila melanogaster
FBpp0085746 A1ZBI6 Drosophila melanogaster
FBpp0071217 Q9W3C1 Drosophila melanogaster
FBpp0070636 Q960X4 Drosophila melanogaster
FBpp0080591 Q9VJA0 Drosophila melanogaster
FBpp0099421 Q2PDV0 Drosophila melanogaster
FBpp0289985 Q9VLU3 Drosophila melanogaster
FBpp0100038 Q59DX8 Drosophila melanogaster
FBpp0070421 Q9W4Y1 Drosophila melanogaster
FBpp0087121 P54361 Drosophila melanogaster
FBpp0087123 A1Z8U2 Drosophila melanogaster
FBpp0087122 A1Z8U1 Drosophila melanogaster
FBpp0080602 Q9VJ98 Drosophila melanogaster
FBpp0072159 Q9W1A9 Drosophila melanogaster
FBpp0089101 Q94521 Drosophila melanogaster
FBpp0082508 Q8MRT7 Drosophila melanogaster
FBpp0085227 Q9V9V9 Drosophila melanogaster
FBpp0080059 Q8IP77 Drosophila melanogaster
FBpp0078873 Q9VMG0 Drosophila melanogaster
FBpp0081612 Q9VH73 Drosophila melanogaster
FBpp0083452 Q9VDC9 Drosophila melanogaster
FBpp0076451 O61613 Drosophila melanogaster
FBpp0084827 Q9VAI4 Drosophila melanogaster
FBpp0075070 Q8IQP3 Drosophila melanogaster
FBpp0087227 Q9NHD5 Drosophila melanogaster
FBpp0072598 Q8IRH2 Drosophila melanogaster