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Protein Domain : IPR002379

Name  V-ATPase proteolipid subunit C-like domain Short Name  ATPase_proteolipid_c_like_dom
Type  Domain Description  Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. There are several different types of transmembrane ATPases, which can differ in function (ATP hydrolysis and/or synthesis), structure (e.g., F-, V- and A-ATPases, which contain rotary motors) and in the type of ions they transport [, ]. The different types include:F-ATPases (F1F0-ATPases), which are found in mitochondria, chloroplasts and bacterial plasma membranes where they are the prime producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases), which are primarily found in eukaryotic and they function as proton pumps that acidify intracellular compartments and, in some cases, transport protons across the plasma membrane []. They are also found in bacteria [].A-ATPases (A1A0-ATPases), which are found in Archaea and function like F-ATPases, though with respect to their structure and some inhibitor responses, A-ATPases are more closely related to the V-ATPases [, ].P-ATPases (E1E2-ATPases), which are found in bacteria and in eukaryotic plasma membranes and organelles, and function to transport a variety of different ions across membranes.E-ATPases, which are cell-surface enzymes that hydrolyse a range of NTPs, including extracellular ATP.The F-ATPases (or F1F0-ATPases) and V-ATPases (or V1V0-ATPases) are each composed of two linked complexes: the F1 or V1 complex contains the catalytic core that synthesizes/hydrolyses ATP, and the F0 or V0 complex that forms the membrane-spanning pore. The F- and V-ATPases all contain rotary motors, one that drives proton translocation across the membrane and one that drives ATP synthesis/hydrolysis [, ].In V-ATPases, there are three proteolipid subunits (c, c' and c'') that form part of the proton-conducting pore, each containing a buried glutamic acid residue that is essential for proton transport, and together they form a hexameric ring spanning the membrane [, ]. Structurally, the c subunits consist of a two antiparallel transmembrane helices. Both helices of one c subunit are connected by a loop on the cytoplasmic side [].This entry represents the V-ATPase proteolipid subunit C like domain found in the V-ATPase proteolipid subunit C and the F-ATP synthase subunit C.

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR020537 ATPase, F0 complex, subunit C, DCCD-binding site ATPase_F0-cplx_csu_DDCD_BS Binding_site

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00137 PFAM IPR002379
SSF81333 SSF IPR002379

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
V-ATPase proteolipid subunit C-like domain   GO:0015078 hydrogen ion transmembrane transporter activity
V-ATPase proteolipid subunit C-like domain   GO:0015991 ATP hydrolysis coupled proton transport
V-ATPase proteolipid subunit C-like domain   GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
V-ATPase proteolipid subunit C-like domain   GO:0015078 hydrogen ion transmembrane transporter activity
V-ATPase proteolipid subunit C-like domain   GO:0015991 ATP hydrolysis coupled proton transport
V-ATPase proteolipid subunit C-like domain   GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain

0 Parent Features

61 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0075822 Q9VTI6 Drosophila melanogaster
FBpp0075821 Q8IQG3 Drosophila melanogaster
FBpp0300391 Q9VFE3 Drosophila melanogaster
FBpp0085135 Q6NN09 Drosophila melanogaster
FBpp0293653 H0RNC4 Drosophila melanogaster
FBpp0086218 A1ZAL7 Drosophila melanogaster
FBpp0079709 Q9VKQ8 Drosophila melanogaster
FBpp0085483 P23380 Drosophila melanogaster
FBpp0288461 Q9VFE5 Drosophila melanogaster
FBpp0281587 Q296J4 Drosophila pseudoobscura
FBpp0275818 Q28WX5 Drosophila pseudoobscura
FBpp0276655 Q290J9 Drosophila pseudoobscura
FBpp0279016 B5DHG5 Drosophila pseudoobscura
FBpp0281396 B5DYR7 Drosophila pseudoobscura
FBpp0281398 B5DYR6 Drosophila pseudoobscura
FBpp0281589 B5DXP5 Drosophila pseudoobscura
FBpp0283028 Q29CE8 Drosophila pseudoobscura
FBpp0159647 B4K626 Drosophila mojavensis
FBpp0160829 B4L198 Drosophila mojavensis
FBpp0160830 B4L197 Drosophila mojavensis
FBpp0162530 B4KLB1 Drosophila mojavensis
FBpp0170495 B4KUH4 Drosophila mojavensis
FBpp0172211 B4K551 Drosophila mojavensis
FBpp0172213 B4K549 Drosophila mojavensis
FBpp0225063 B4M5U7 Drosophila virilis
FBpp0225708 B4LC71 Drosophila virilis
FBpp0225709 B4LC70 Drosophila virilis
FBpp0226360 B4LRX2 Drosophila virilis
FBpp0235297 B4LIM5 Drosophila virilis
FBpp0239109 B4M0U4 Drosophila virilis