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Protein Domain : IPR000014

Name  PAS domain Short Name  PAS
Type  Domain Description  PAS domains are involved in many signalling proteins where theyare used as a signal sensor domain []. PAS domains appear in archaea,bacteria and eukaryotes. Several PAS-domain proteins are known todetect their signal by way of an associated cofactor. Haeme,flavin, and a 4-hydroxycinnamyl chromophore are used in differentproteins. The PAS domain was named after three proteins that itoccurs in: Per- period circadian proteinArnt- Ah receptor nuclear translocator proteinSim- single-minded protein.PAS domains are often associated withPAC domains . It appears that these domains are directly linked, and that together they form the conserved 3D PAS fold. The division between the PAS and PAC domains is caused by major differences in sequences in the region connecting these two motifs []. In human PAS kinase, this region has been shown to be very flexible, and adopts different conformations depending on the bound ligand [].Probably the most surprising identification of a PAS domain was that inEAG-like K+-channels [].

Publication Counts Displayer

3 Child Features

DB identifier Name Short Name Type
IPR013767 PAS fold PAS_fold Domain
IPR013655 PAS fold-3 PAS_fold_3 Domain
IPR013656 PAS fold-4 PAS_4 Domain

0 Contains

6 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF13188 PFAM IPR000014
PF13426 PFAM IPR000014
PS50112 PROFILE IPR000014
SM00091 SMART IPR000014
TIGR00229 TIGRFAMs IPR000014
SSF55785 SSF IPR000014

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

14 Found In

DB identifier Name Short Name Type
IPR003949 Potassium channel, voltage-dependent, EAG K_chnl_volt-dep_EAG Family
IPR003950 Potassium channel, voltage-dependent, ELK K_chnl_volt-dep_ELK Family
IPR011785 Transcription regulator PpsR Tscrpt_reg_PpsR-CrtJ Family
IPR012704 Signal transduction response regulator, propionate catabolism, transcriptional regulator PrpR Sig_transdc_resp-reg_PrpR Family
IPR012226 Oxygen sensor diguanylate cyclase/c-di-GMP phosphodiesterase Dos Family
IPR001294 Phytochrome Phytochrome Family
IPR015524 Period circadian protein 3 Per_circ_prot_3 Family
IPR014285 Nitrogen fixation negative regulator NifL N_fixation_neg-reg_NifL Family
IPR014409 Signal transduction histidine kinase, hybrid-type, aerobic respiration control ArcB Sig_transdc_His_kin_hyb_ArcB Family
IPR014310 Signal transduction histidine kinase, phosphate regulon sensor PhoR Sig_transdc_His_kinase_PhoR Family
IPR012129 Phytochrome A/B/C/D/E Phytochrome_A-E Family
IPR012130 Photoactive yellow-protein PYP Family
IPR017181 Signal transduction histidine kinase, CHASE2/PAS sensor domain-containing, predicted Sig_transdc_His_kin_CHASE2_PAS Family
IPR017232 Signal transduction histidine kinase, nitrogen fixation and metabolism regulator Sig_transdc_His_kinase_NtrY Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
PAS domain   GO:0004871 signal transducer activity
PAS domain   GO:0007165 signal transduction

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
PAS domain   GO:0004871 signal transducer activity
PAS domain   GO:0007165 signal transduction

0 Parent Features

190 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0070455 M9PGJ3 Drosophila melanogaster
FBpp0099478 O61735 Drosophila melanogaster
FBpp0081483 O15945 Drosophila melanogaster
FBpp0085981 A1ZB14 Drosophila melanogaster
FBpp0074693 O61734 Drosophila melanogaster
FBpp0301718 M9PHT2 Drosophila melanogaster
FBpp0301717 M9PH56 Drosophila melanogaster
FBpp0301719 M9PHM3 Drosophila melanogaster
FBpp0073772 Q02280 Drosophila melanogaster
FBpp0292377 M9MSD1 Drosophila melanogaster
FBpp0292378 M9MSA6 Drosophila melanogaster
FBpp0110308 Q0KHS8 Drosophila melanogaster
FBpp0072069 Q95SH0 Drosophila melanogaster
FBpp0082768 Q9VEV9 Drosophila melanogaster
FBpp0310594 Q6NNF2 Drosophila melanogaster
FBpp0310591 Q8MLR0 Drosophila melanogaster
FBpp0310589 Q8MLR1 Drosophila melanogaster
FBpp0310590 Q9W1L9 Drosophila melanogaster
FBpp0292297 Q9VXW7 Drosophila melanogaster
FBpp0073368 Q9VYW2 Drosophila melanogaster
FBpp0112206 A8JRD5 Drosophila melanogaster
FBpp0289845 Q9VBH3 Drosophila melanogaster
FBpp0112205 A8JRD4 Drosophila melanogaster
FBpp0292873 Q9VLD9 Drosophila melanogaster
FBpp0292876 M9MRG5 Drosophila melanogaster
FBpp0310748 B7Z0S3 Drosophila melanogaster
FBpp0310747 Q24167 Drosophila melanogaster
FBpp0292875 M9MRJ8 Drosophila melanogaster
FBpp0293513 M9ND53 Drosophila melanogaster
FBpp0293064 H9TV77 Drosophila melanogaster