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Protein Domain : IPR027417

Name  P-loop containing nucleoside triphosphate hydrolase Short Name  P-loop_NTPase
Type  Domain Description  The P-loop NTPase fold is the most prevalent domain of the several distinctnucleotide-binding protein folds.The most common reaction catalysed by enzymes of the P-loop NTPase fold is the hydrolysis of the beta-gamma phosphate bond of a bound nucleoside triphosphate (NTP). The energy from NTP hydrolysis is typically utilised to induce conformational changes in other molecules, which constitutes the basis of the biological functions of most P-loop NTPases. P-loop NTPases show substantial substrate preference for either ATP or GTP []. P-loop NTPases are characterised by two conserved sequence signatures, theWalker A The Walker A motif (the P-loop proper) and Walker B motifs which bind, respectively, the beta and gamma phosphate moieties of the bound NTP, and a Mg2+ cation [].P-loop ATPase domains belong to one of the two major divisions. The kinase-GTPase (KG) division includes the kinases and GTPases, and the ASCE division, characterised by an additional strand in the core sheet, which is locatedbetween the P-loop strand and the Walker B strand. Most members of the ASCE division utilise ATP and members of this group include AAA+, ABC, PilT, HerA-FtsK, superfamily 1/2 (SF1/2) helicases, and the RecA/ATP-synthase superfamilies of ATPases, etc [, ].

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR029007 MobB-type P-loop domain MobB-typ_P-loop Domain
IPR003593 AAA+ ATPase domain AAA+_ATPase Domain

0 Contains

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
G3DSA:3.40.50.300 GENE3D IPR027417
SSF52540 SSF IPR027417

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

7331 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0292925 M9MRE4 Drosophila melanogaster
FBpp0292924 B5RJR1 Drosophila melanogaster
FBpp0070078 Q8SWW9 Drosophila melanogaster
FBpp0087479 Q7KN62 Drosophila melanogaster
FBpp0302542 Q86B52 Drosophila melanogaster
FBpp0086122 Q7KLI1 Drosophila melanogaster
FBpp0086121 Q9U8R4 Drosophila melanogaster
FBpp0111700 Q9VDJ9 Drosophila melanogaster
FBpp0084486 Q8SZ30 Drosophila melanogaster
FBpp0077107 Q9VR29 Drosophila melanogaster
FBpp0076021 Q9V3C4 Drosophila melanogaster
FBpp0074487 Q0KHQ6 Drosophila melanogaster
FBpp0074486 Q9VWH7 Drosophila melanogaster
FBpp0084036 Q9VC57 Drosophila melanogaster
FBpp0077291 Q8MRL3 Drosophila melanogaster
FBpp0072614 P40792 Drosophila melanogaster
FBpp0075282 Q9VUV9 Drosophila melanogaster
FBpp0073828 Q9VXW2 Drosophila melanogaster
FBpp0072026 P12428 Drosophila melanogaster
FBpp0099685 Q9VWF7 Drosophila melanogaster
FBpp0071030 Q9W3Q0 Drosophila melanogaster
FBpp0297173 Q7KT22 Drosophila melanogaster
FBpp0088655 Q9VUZ2 Drosophila melanogaster
FBpp0088654 Q86BP6 Drosophila melanogaster
FBpp0083958 Q9VCB8 Drosophila melanogaster
FBpp0086328 P17210 Drosophila melanogaster
FBpp0071794 P35381 Drosophila melanogaster
FBpp0078729 Q9VMQ7 Drosophila melanogaster
FBpp0074688 O97159 Drosophila melanogaster
FBpp0304462 M9PIA6 Drosophila melanogaster