modENCODE |  Help |  blog

Protein Domain : IPR011989

Name  Armadillo-like helical Short Name  ARM-like
Type  Domain Description  This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix, where the repeats that make up this structure are arranged about a common axis []. These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains, including the armadillo repeat (found in beta-catenins and importins), the HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G), the PHAT domain (found in Smaug RNA-binding protein), the leucine-rich repeat variant, the Pumilo repeat, and in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low, however they exhibit considerable structural similarity. Furthermore, the number of repeats present in the superhelical structure can vary between orthologues, indicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats [].

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR024574 Domain of unknown function DUF3361 DUF3361 Domain

16 Contains

DB identifier Name Short Name Type
IPR000225 Armadillo Armadillo Repeat
IPR000357 HEAT HEAT Repeat
IPR021133 HEAT, type 2 HEAT_type_2 Repeat
IPR013598 Exportin-1/Importin-beta-like Exportin-1/Importin-b-like Domain
IPR002015 Proteasome/cyclosome repeat Proteasome/cyclosome_rpt Repeat
IPR013932 TATA-binding protein interacting (TIP20) TATA-bd_TIP120 Domain
IPR001313 Pumilio RNA-binding repeat Pumilio_RNA-bd_rpt Repeat
IPR014877 CRM1 C-terminal domain CRM1_C_dom Domain
IPR001494 Importin-beta, N-terminal domain Importin-beta_N Domain
IPR004155 PBS lyase HEAT-like repeat PBS_lyase_HEAT Repeat
IPR007205 FAM203 N-terminal FAM203_N Domain
IPR005043 CAS/CSE, C-terminal CAS_CSE1_C Domain
IPR013713 Exportin/Importin, Cse1-like Cse1 Domain
IPR007206 FAM203 C-terminal FAM203_C Domain
IPR013918 Nucleotide exchange factor Fes1 Nucleotide_exch_fac_Fes1 Domain
IPR004830 Leucine rich repeat variant LRR_variant Repeat

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
G3DSA:1.25.10.10 GENE3D IPR011989

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

16 Found In

DB identifier Name Short Name Type
IPR004908 ATPase, V1 complex, subunit H ATPase_V1-cplx_hsu Family
IPR017107 Adaptor protein complex AP-1, gamma subunit AP1_complex_gsu Family
IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal Clathrin/coatomer_adapt-like_N Domain
IPR017105 Adaptor protein complex AP-3, delta subunit AP3_complex_dsu Family
IPR013284 Beta-catenin Beta-catenin Family
IPR016642 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit 26S_Psome_Rpn2 Family
IPR016460 Coatomer beta subunit (COPB1) COPB1 Family
IPR008658 Kinesin-associated protein 3 KAP3 Family
IPR017104 Adaptor protein complex AP-2, alpha subunit AP2_complex_asu Family
IPR017106 Coatomer gamma subunit Coatomer_gsu Family
IPR007673 Condensin subunit 1 Condensin_cplx_su1 Family
IPR006911 Armadillo repeat-containing domain ARM-rpt_dom Domain
IPR016342 AP-1, 2,4 complex subunit beta AP_complex_bsu_1_2_4 Family
IPR008665 LRV FeS4 cluster LRV_FeS Domain
IPR017109 Adaptor protein complex AP-4, epsilon subunit AP4_complex_esu Family
IPR011959 Conserved hypothetical protein CHP02270 CHP02270 Family

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR016024 Armadillo-type fold ARM-type_fold Domain

1487 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0110406 Q7PLI0 Drosophila melanogaster
FBpp0072595 Q9W0E8 Drosophila melanogaster
FBpp0078775 Q9VML2 Drosophila melanogaster
FBpp0075117 P91891 Drosophila melanogaster
FBpp0083039 Q9VEC5 Drosophila melanogaster
FBpp0087699 A1Z7S0 Drosophila melanogaster
FBpp0085155 Q8I0G5 Drosophila melanogaster
FBpp0074558 Q24253 Drosophila melanogaster
FBpp0088945 E8NH12 Drosophila melanogaster
FBpp0088490 P91926 Drosophila melanogaster
FBpp0085514 A1Z6S7 Drosophila melanogaster
FBpp0089175 A1Z6S6 Drosophila melanogaster
FBpp0088470 Q9NBD7 Drosophila melanogaster
FBpp0086416 Q7K0Q2 Drosophila melanogaster
FBpp0081862 Q9VGP4 Drosophila melanogaster
FBpp0082975 Q0KI58 Drosophila melanogaster
FBpp0082976 Q8IN90 Drosophila melanogaster
FBpp0088355 Q9VND0 Drosophila melanogaster
FBpp0084818 Q9VAJ1 Drosophila melanogaster
FBpp0077399 Q9VQG0 Drosophila melanogaster
FBpp0099759 Q95RI2 Drosophila melanogaster
FBpp0076777 Q9VRS0 Drosophila melanogaster
FBpp0110411 Q7PLI2 Drosophila melanogaster
FBpp0080003 Q9VK45 Drosophila melanogaster
FBpp0307598 M9PFS0 Drosophila melanogaster
FBpp0082148 Q9VG59 Drosophila melanogaster
FBpp0086892 Q7JYM7 Drosophila melanogaster
FBpp0076711 Q9VRV9 Drosophila melanogaster
FBpp0082402 Q8INF7 Drosophila melanogaster
FBpp0099974 P36179 Drosophila melanogaster