modENCODE |  Help |  blog

Protein Domain : IPR020683

Name  Ankyrin repeat-containing domain Short Name  Ankyrin_rpt-contain_dom
Type  Domain Description  This entry represents the ankyrin repeat-containing domain. These domains contain multiple repeats of a beta(2)-alpha(2) motif. The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes.The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers []. The repeat has been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it. The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures [, , , ]. Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90oangle. The repeats stack together to form an L-shaped structure [, ].

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR002110 Ankyrin repeat Ankyrin_rpt Repeat

5 Cross References

Source . Name

Subject . Primary Identifier
PF11929 PFAM IPR020683
PF12796 PFAM IPR020683
PS50297 PROFILE IPR020683
SSF48403 SSF IPR020683

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

19 Found In

DB identifier Name Short Name Type
IPR004729 Transient receptor potential channel TRP_channel Family
IPR008297 Notch Notch Family
IPR016253 Integrin-linked protein kinase Integrin-linked_kinase Family
IPR020676 Death-associated protein kinase 1 DAPK1 Family
IPR022336 Neurogenic locus Notch 2 Notch_2 Family
IPR022331 Neurogenic locus Notch 3 Notch_3 Family
IPR008348 Transient receptor potential channel, vanilloid 4 TRPV4_channel Family
IPR008347 Transient receptor potential channel, vanilloid 1-4 TRPV1-4_channel Family
IPR008345 Transient receptor potential channel, vanilloid 6 TRPV6_channel Family
IPR008344 Transient receptor potential cation channel subfamily V member 5/6 TRPV5/TRPV6 Family
IPR022355 Neurogenic locus Notch 4 Notch_4 Family
IPR017417 Protein phosphatase 1, regulatory subunit 16A/B, eukaryote Pase-1_reg_su_16AB_euk Family
IPR017408 Arginine N-methyltransferase 2 Arginine_N-MeTrfase_2 Family
IPR017401 Protein phosphatase 1, regulatory subunit 12A/B/C, eukaryote Pase-1_reg_su_12A/B/C_euk Family
IPR017362 DNA-binding, RFXANK DNA-bd_RFXANK Family
IPR022362 Neurogenic locus Notch 1 Notch_1 Family
IPR005463 Transient receptor potential channel, canonical 7 TRPC7_channel Family
IPR005460 Transient receptor potential channel, canonical 4 TRPC4_channel Family
IPR005457 Transient receptor potential channel, canonical 1 TRPC1_channel Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

1134 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086524 Q9V7A7 Drosophila melanogaster
FBpp0111700 Q9VDJ9 Drosophila melanogaster
FBpp0080123 Q9NGC3 Drosophila melanogaster
FBpp0290627 Q8MQX9 Drosophila melanogaster
FBpp0290629 Q9VX44 Drosophila melanogaster
FBpp0074816 Q8SY34 Drosophila melanogaster
FBpp0080686 Q9VJ14 Drosophila melanogaster
FBpp0072423 Q9W0T5 Drosophila melanogaster
FBpp0075275 Q9VUX2 Drosophila melanogaster
FBpp0084264 Q9VBP3 Drosophila melanogaster
FBpp0076922 Q9VRG6 Drosophila melanogaster
FBpp0087555 P48994 Drosophila melanogaster
FBpp0072323 Q9W0Y6 Drosophila melanogaster
FBpp0070595 Q9W4N6 Drosophila melanogaster
FBpp0081252 Q9VHY7 Drosophila melanogaster
FBpp0079944 Q9VKB1 Drosophila melanogaster
FBpp0290790 Q9VUX6 Drosophila melanogaster
FBpp0085618 P42570 Drosophila melanogaster
FBpp0070483 P07207 Drosophila melanogaster
FBpp0074851 Q8IQT4 Drosophila melanogaster
FBpp0075788 Q9VTS8 Drosophila melanogaster
FBpp0075785 Q9VTS9 Drosophila melanogaster
FBpp0075789 Q9VTS6 Drosophila melanogaster
FBpp0290111 Q960W9 Drosophila melanogaster
FBpp0085959 Q7K3G2 Drosophila melanogaster
FBpp0084091 Q9VC09 Drosophila melanogaster
FBpp0077644 Q9VPY3 Drosophila melanogaster
FBpp0078709 Q9VMR4 Drosophila melanogaster
FBpp0086382 Q24145 Drosophila melanogaster
FBpp0292230 M9MS19 Drosophila melanogaster