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Protein Domain : IPR008271

Name  Serine/threonine-protein kinase, active site Short Name  Ser/Thr_kinase_AS
Type  Active_site Description  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Eukaryotic protein kinases [, , , ]are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. There are a number of conserved regions in the catalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue, which has been shown to be involved in ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residue, which is important for the catalytic activity of the enzyme []. This signature contains the active site aspartate residue.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00108 PROSITE IPR008271

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

52 Found In

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain
IPR000719 Protein kinase domain Prot_kinase_dom Domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain Ser/Thr_dual-sp_kinase_dom Domain
IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase Ca/CaM-dep_Ca-dep_prot_Kinase Family
IPR015727 Protein kinase C mu-related Protein_Kinase_C_mu-related Family
IPR016232 cGMP-dependent protein kinase cGMP-dependent_protein_kinase Family
IPR002374 cGMP-dependent kinase cGMP_dep_kinase Family
IPR000239 GPCR kinase GPCR_kinase Family
IPR012233 Protein kinase C, zeta/iota PKC_zeta Family
IPR003527 Mitogen-activated protein (MAP) kinase, conserved site MAP_kinase_CS Conserved_site
IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2 MAPK_ERK1/2 Family
IPR016238 Ribosomal protein S6 kinase Ribosomal_S6_kinase Family
IPR020675 Myosin light chain kinase-related Myosin_light_ch_kinase-rel Family
IPR017184 Serine/threonine-protein kinase Unc-51 Ser/Thr_kinase_Unc51 Family
IPR008351 Mitogen-activated protein (MAP) kinase, JNK MAPK_JNK Family
IPR016239 Ribosomal protein S6 kinase II Ribosomal_S6_kinase_II Family
IPR014376 Protein kinase C, delta/epsilon/eta/theta types Prot_kin_PKC_delta Family
IPR002291 Phosphorylase kinase, gamma catalytic subunit Phosph_kin_gamma Family
IPR017164 Wee1-like protein kinase Wee1-like_protein_kinase Family
IPR014375 Protein kinase C, alpha/beta/gamma types Protein_kinase_C_a/b/g Family
IPR016235 Tyrosine/threonine-protein kinase, Cdc2 inhibitor Tyr/Thr_kinase_Cdc2_inhib Family
IPR020684 Rho-associated protein kinase Rho-assoc_coiled-coil_kin Family
IPR020679 Serine/threonine-protein kinase Tda1 Ser/Thr_kinase_Tda1 Family
IPR020676 Death-associated protein kinase 1 DAPK1 Family
IPR015725 Telokin/Myosin light chain kinase Telokin/Myosin_light_ch_kin Family
IPR015726 Serine/threonine protein kinase, striated muscle-specific Ser/Thr_kin_striated_muscle-sp Family
IPR020682 Obscurin-myosin light chain kinase Obscurin-myosin_light-ch_kin Family
IPR017322 Receptor-interacting serine/threonine-protein kinase 2 Rcpt-int_Ser/Thr_kinase-2 Family
IPR017424 Mitogen-activated protein (MAP) kinase kinase kinase 8 MAPKKK8 Family
IPR017419 Mitogen-activated protein kinase kinase kinase, 12/13 MAP3K12_MAP3K13 Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Serine/threonine-protein kinase, active site   GO:0004674 protein serine/threonine kinase activity
Serine/threonine-protein kinase, active site   GO:0006468 protein phosphorylation

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Serine/threonine-protein kinase, active site   GO:0004674 protein serine/threonine kinase activity
Serine/threonine-protein kinase, active site   GO:0006468 protein phosphorylation

0 Parent Features

2355 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0289022 Q8IML9 Drosophila melanogaster
FBpp0289025 Q86B72 Drosophila melanogaster
FBpp0289031 Q0KI03 Drosophila melanogaster
FBpp0289029 Q86B73 Drosophila melanogaster
FBpp0289021 P49762 Drosophila melanogaster
FBpp0289026 B7Z0R6 Drosophila melanogaster
FBpp0289020 A4V3J9 Drosophila melanogaster
FBpp0076820 Q94533 Drosophila melanogaster
FBpp0087908 Q7JQ36 Drosophila melanogaster
FBpp0087909 Q95U21 Drosophila melanogaster
FBpp0111700 Q9VDJ9 Drosophila melanogaster
FBpp0084466 Q7KRY6 Drosophila melanogaster
FBpp0072194 Q9W1B0 Drosophila melanogaster
FBpp0303422 M9PEF9 Drosophila melanogaster
FBpp0073578 Q23977 Drosophila melanogaster
FBpp0073579 M9PH06 Drosophila melanogaster
FBpp0304825 Q9VPW3 Drosophila melanogaster
FBpp0079769 Q9VKN7 Drosophila melanogaster
FBpp0083530 Q9VD82 Drosophila melanogaster
FBpp0099769 P32023 Drosophila melanogaster
FBpp0292076 M9MRD8 Drosophila melanogaster
FBpp0083054 Q9VE58 Drosophila melanogaster
FBpp0075283 P16912 Drosophila melanogaster
FBpp0078437 Q7JWT4 Drosophila melanogaster
FBpp0078832 Q8T4D4 Drosophila melanogaster
FBpp0076824 Q9NI63 Drosophila melanogaster
FBpp0070043 P08181 Drosophila melanogaster
FBpp0290731 Q4QQA3 Drosophila melanogaster
FBpp0288689 Q9VN23 Drosophila melanogaster
FBpp0308994 Q0KID3 Drosophila melanogaster