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Protein Domain : IPR002290

Name  Serine/threonine- /dual specificity protein kinase, catalytic domain Short Name  Ser/Thr_dual-sp_kinase_dom
Type  Domain Description  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Eukaryotic protein kinases [, , , , ]are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue, which has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme [].This entry represents the protein kinase catalytic domain found in a number of serine/threonine-protein kinases and dual specificity protein kinases.

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier Name Short Name Type
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR008271 Serine/threonine-protein kinase, active site Ser/Thr_kinase_AS Active_site
IPR003527 Mitogen-activated protein (MAP) kinase, conserved site MAP_kinase_CS Conserved_site

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
SM00220 SMART IPR002290

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

30 Found In

DB identifier Name Short Name Type
IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase Ca/CaM-dep_Ca-dep_prot_Kinase Family
IPR015727 Protein kinase C mu-related Protein_Kinase_C_mu-related Family
IPR016232 cGMP-dependent protein kinase cGMP-dependent_protein_kinase Family
IPR002374 cGMP-dependent kinase cGMP_dep_kinase Family
IPR000239 GPCR kinase GPCR_kinase Family
IPR012233 Protein kinase C, zeta/iota PKC_zeta Family
IPR016238 Ribosomal protein S6 kinase Ribosomal_S6_kinase Family
IPR020675 Myosin light chain kinase-related Myosin_light_ch_kinase-rel Family
IPR017184 Serine/threonine-protein kinase Unc-51 Ser/Thr_kinase_Unc51 Family
IPR016239 Ribosomal protein S6 kinase II Ribosomal_S6_kinase_II Family
IPR014376 Protein kinase C, delta/epsilon/eta/theta types Prot_kin_PKC_delta Family
IPR002291 Phosphorylase kinase, gamma catalytic subunit Phosph_kin_gamma Family
IPR014375 Protein kinase C, alpha/beta/gamma types Protein_kinase_C_a/b/g Family
IPR021160 Mitogen-activated protein (MAP) kinase kinase kinase kinase MAPKKKK Family
IPR020684 Rho-associated protein kinase Rho-assoc_coiled-coil_kin Family
IPR020679 Serine/threonine-protein kinase Tda1 Ser/Thr_kinase_Tda1 Family
IPR020676 Death-associated protein kinase 1 DAPK1 Family
IPR015725 Telokin/Myosin light chain kinase Telokin/Myosin_light_ch_kin Family
IPR015726 Serine/threonine protein kinase, striated muscle-specific Ser/Thr_kin_striated_muscle-sp Family
IPR020682 Obscurin-myosin light chain kinase Obscurin-myosin_light-ch_kin Family
IPR008350 Mitogen-activated protein (MAP) kinase, ERK3/4 MAPK_ERK3/4 Family
IPR020658 Serine/threonine-protein kinase Plk3 Ser/Thr_kinase_Plk3 Family
IPR016237 Serine/threonine-protein kinase, Ulk1/Ulk2 Ser/Thr_kin_STPK_Ulk-1/2 Family
IPR016242 Serine/threonine-protein kinase Mps1-like, Saccharomycetes Ser/Thr_kinase_Mps1_Saccharo Family
IPR017090 Serine/threonine-protein kinase, SIK1/2 Ser/Thr_kinase_SIK1/2 Family
IPR017239 Mitogen-activated protein (MAP) kinase kinase kinase Ste11 MAPKKK_Ste11 Family
IPR017348 Proto-oncogene serine/threonine-protein kinase Pim-1 Ser/Thr_kinase_Pim-1 Family
IPR016256 Serine/threonine-protein kinase Rad53 Ser/Thr_kinase_Rad53 Family
IPR017405 Citron Rho-interacting kinase Citron_Rho-interacting_kinase Family
IPR017240 Mitogen-activated protein (MAP) kinase kinase kinase, SSK22 MAPKKK_SSK22 Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Serine/threonine- /dual specificity protein kinase, catalytic domain   GO:0004672 protein kinase activity
Serine/threonine- /dual specificity protein kinase, catalytic domain   GO:0005524 ATP binding
Serine/threonine- /dual specificity protein kinase, catalytic domain   GO:0006468 protein phosphorylation

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Serine/threonine- /dual specificity protein kinase, catalytic domain   GO:0004672 protein kinase activity
Serine/threonine- /dual specificity protein kinase, catalytic domain   GO:0005524 ATP binding
Serine/threonine- /dual specificity protein kinase, catalytic domain   GO:0006468 protein phosphorylation

1 Parent Features

DB identifier Name Short Name Type
IPR000719 Protein kinase domain Prot_kinase_dom Domain

1722 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0289022 Q8IML9 Drosophila melanogaster
FBpp0289025 Q86B72 Drosophila melanogaster
FBpp0289031 Q0KI03 Drosophila melanogaster
FBpp0289029 Q86B73 Drosophila melanogaster
FBpp0289021 P49762 Drosophila melanogaster
FBpp0289026 B7Z0R6 Drosophila melanogaster
FBpp0289020 A4V3J9 Drosophila melanogaster
FBpp0076820 Q94533 Drosophila melanogaster
FBpp0072194 Q9W1B0 Drosophila melanogaster
FBpp0303422 M9PEF9 Drosophila melanogaster
FBpp0073578 Q23977 Drosophila melanogaster
FBpp0073579 M9PH06 Drosophila melanogaster
FBpp0304825 Q9VPW3 Drosophila melanogaster
FBpp0079769 Q9VKN7 Drosophila melanogaster
FBpp0083530 Q9VD82 Drosophila melanogaster
FBpp0099769 P32023 Drosophila melanogaster
FBpp0292076 M9MRD8 Drosophila melanogaster
FBpp0083054 Q9VE58 Drosophila melanogaster
FBpp0075283 P16912 Drosophila melanogaster
FBpp0078832 Q8T4D4 Drosophila melanogaster
FBpp0070043 P08181 Drosophila melanogaster
FBpp0290731 Q4QQA3 Drosophila melanogaster
FBpp0288689 Q9VN23 Drosophila melanogaster
FBpp0308994 Q0KID3 Drosophila melanogaster
FBpp0099818 P83102 Drosophila melanogaster
FBpp0075702 Q9VTY8 Drosophila melanogaster
FBpp0083010 Q9VE91 Drosophila melanogaster
FBpp0072271 Q9W179 Drosophila melanogaster
FBpp0099900 Q59E61 Drosophila melanogaster
FBpp0072270 Q8MLP1 Drosophila melanogaster