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Protein Domain : IPR000719

Name  Protein kinase domain Short Name  Prot_kinase_dom
Type  Domain Description  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Eukaryotic protein kinases [, , , , ]are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue, which has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme []. This entry represents the protein kinase domain containing the catalytic function of protein kinases []. This domain is found in serine/threonine-protein kinases, tyrosine-protein kinases and dual specificity protein kinases.

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3 Child Features

DB identifier Name Short Name Type
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain Ser/Thr_dual-sp_kinase_dom Domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain Ser-Thr/Tyr_kinase_cat_dom Domain
IPR027916 Protein kinase-like domain, Apicomplexa Kinase-like_dom_Apicomplexa Domain

6 Contains

DB identifier Name Short Name Type
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR008271 Serine/threonine-protein kinase, active site Ser/Thr_kinase_AS Active_site
IPR008266 Tyrosine-protein kinase, active site Tyr_kinase_AS Active_site
IPR003527 Mitogen-activated protein (MAP) kinase, conserved site MAP_kinase_CS Conserved_site
IPR002011 Tyrosine-protein kinase, receptor class II, conserved site Tyr_kinase_rcpt_2_CS Conserved_site
IPR001824 Tyrosine-protein kinase, receptor class III, conserved site Tyr_kinase_rcpt_3_CS Conserved_site

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00069 PFAM IPR000719
PS50011 PROFILE IPR000719

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

56 Found In

DB identifier Name Short Name Type
IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase Ca/CaM-dep_Ca-dep_prot_Kinase Family
IPR016232 cGMP-dependent protein kinase cGMP-dependent_protein_kinase Family
IPR002374 cGMP-dependent kinase cGMP_dep_kinase Family
IPR000239 GPCR kinase GPCR_kinase Family
IPR020766 Receptor-like tyrosine-protein kinase kin-15/kin-16 kin-15/kin-16 Family
IPR016247 Tyrosine-protein kinase, receptor ROR Tyr_kinase_rcpt_ROR Family
IPR020675 Myosin light chain kinase-related Myosin_light_ch_kinase-rel Family
IPR017184 Serine/threonine-protein kinase Unc-51 Ser/Thr_kinase_Unc51 Family
IPR002291 Phosphorylase kinase, gamma catalytic subunit Phosph_kin_gamma Family
IPR016257 Ephrin receptor type-A /type-B Tyr_kinase_ephrin_rcpt Family
IPR017164 Wee1-like protein kinase Wee1-like_protein_kinase Family
IPR021160 Mitogen-activated protein (MAP) kinase kinase kinase kinase MAPKKKK Family
IPR016248 Fibroblast growth factor receptor family FGF_rcpt_fam Family
IPR016235 Tyrosine/threonine-protein kinase, Cdc2 inhibitor Tyr/Thr_kinase_Cdc2_inhib Family
IPR020684 Rho-associated protein kinase Rho-assoc_coiled-coil_kin Family
IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2) VEGFR2_rcpt Family
IPR020691 Ephrin type-A receptor 8 EphrinA_rcpt8 Family
IPR016246 Tyrosine-protein kinase, insulin-like receptor Tyr_kinase_insulin-like_rcpt Family
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2 Tyr_kinase_non-rcpt_Jak/Tyk2 Family
IPR020693 Tyrosine-protein kinase, non-receptor Jak2 Tyr_kinase_non-rcpt_Jak2 Family
IPR020775 Tyrosine-protein kinase, non-receptor Jak3 Tyr_kinase_non-rcpt_Jak3 Family
IPR020776 Tyrosine-protein kinase, non-receptor Jak1 Tyr_kinase_non-rcpt_Jak1 Family
IPR020777 Tyrosine-protein kinase, neurotrophic receptor Tyr_kinase_NGF_rcpt Family
IPR020446 Tyrosine-protein kinase, neurotrophic receptor, type 3 Tyr_kin_neurotrophic_rcpt_3 Family
IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2 Tyr_kin_neurotrophic_rcpt_2 Family
IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1 Tyr_kinase_neurotrophic_rcpt_1 Family
IPR020679 Serine/threonine-protein kinase Tda1 Ser/Thr_kinase_Tda1 Family
IPR020676 Death-associated protein kinase 1 DAPK1 Family
IPR015725 Telokin/Myosin light chain kinase Telokin/Myosin_light_ch_kin Family
IPR015726 Serine/threonine protein kinase, striated muscle-specific Ser/Thr_kin_striated_muscle-sp Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein kinase domain   GO:0004672 protein kinase activity
Protein kinase domain   GO:0005524 ATP binding
Protein kinase domain   GO:0006468 protein phosphorylation

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein kinase domain   GO:0004672 protein kinase activity
Protein kinase domain   GO:0005524 ATP binding
Protein kinase domain   GO:0006468 protein phosphorylation

1 Parent Features

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain

4843 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0289022 Q8IML9 Drosophila melanogaster
FBpp0289025 Q86B72 Drosophila melanogaster
FBpp0289031 Q0KI03 Drosophila melanogaster
FBpp0289029 Q86B73 Drosophila melanogaster
FBpp0289021 P49762 Drosophila melanogaster
FBpp0289026 B7Z0R6 Drosophila melanogaster
FBpp0289020 A4V3J9 Drosophila melanogaster
FBpp0076820 Q94533 Drosophila melanogaster
FBpp0080736 Q27324 Drosophila melanogaster
FBpp0303242 M9PDD9 Drosophila melanogaster
FBpp0087908 Q7JQ36 Drosophila melanogaster
FBpp0087909 Q95U21 Drosophila melanogaster
FBpp0111700 Q9VDJ9 Drosophila melanogaster
FBpp0084466 Q7KRY6 Drosophila melanogaster
FBpp0072194 Q9W1B0 Drosophila melanogaster
FBpp0303422 M9PEF9 Drosophila melanogaster
FBpp0073578 Q23977 Drosophila melanogaster
FBpp0073579 M9PH06 Drosophila melanogaster
FBpp0304825 Q9VPW3 Drosophila melanogaster
FBpp0079769 Q9VKN7 Drosophila melanogaster
FBpp0083530 Q9VD82 Drosophila melanogaster
FBpp0099769 P32023 Drosophila melanogaster
FBpp0099944 P00528 Drosophila melanogaster
FBpp0292076 M9MRD8 Drosophila melanogaster
FBpp0083054 Q9VE58 Drosophila melanogaster
FBpp0075283 P16912 Drosophila melanogaster
FBpp0078437 Q7JWT4 Drosophila melanogaster
FBpp0078832 Q8T4D4 Drosophila melanogaster
FBpp0076824 Q9NI63 Drosophila melanogaster
FBpp0070043 P08181 Drosophila melanogaster