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Protein Domain : IPR015433

Name  Phosphatidylinositol Kinase Short Name  PI_Kinase
Type  Family Description  This group of proteins is comprised entirely of phosphatidylinositol 3- and phosphatidylinositol 4-kinases. Phosphatidylinositol 3-kinase (PI3-kinase) []is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. The three products of PI3-kinase, PI-3-P, PI-3,4-P(2) and PI-3,4,5-P(3), function as secondary messengers in cell signalling. Phosphatidylinositol 4-kinase (PI4-kinase) []acts on phosphatidylinositol (PI) in the first committed step of the production of the secondary messenger inositol-1,4,5-trisphosphate. The PI3- and PI4-kinases share a well-conserved domain at their C-terminal section, which is distantly related to the catalytic domain of protein kinases [, ]. The catalytic domain of PI3K has a bilobal structure with a small N-terminal lobe and a large C-terminal lobe; this structure is often found in other ATP-dependent kinases. The core of this catalytic domain is the most conserved region of the PI3Ks. The ATP cofactor binds in the crevice formed by the N-and C-terminal lobes, a loop between two strands provides a hydrophobic pocket for binding of the adenine moiety, and a lysine residue interacts with the alpha-phosphate. In contrast to other protein kinases, the PI3K loop interacts with the phosphates of the ATP, known as the glycine-rich or P-loop, contains no glycine residues. Instead, contact with the ATP -phosphate is maintained through the side chain of a conserved serine residue.

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR027003 Phosphatidylinositol 4-kinase Phosphatidylino_kinase Family
IPR008290 Phosphatidylinositol 3-kinase, Vps34 type PI3K_Vps34 Family

7 Contains

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain PI3/4_kinase_cat_dom Domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site PI3/4_kinase_CS Conserved_site
IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain PI3K_adapt-bd_dom Domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain PI3K_C2_dom Domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain PI3K_Ras-bd_dom Domain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain PInositide-3_kin_accessory_dom Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR10048 PANTHER IPR015433

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Phosphatidylinositol Kinase   GO:0046854 phosphatidylinositol phosphorylation
Phosphatidylinositol Kinase   GO:0048015 phosphatidylinositol-mediated signaling

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Phosphatidylinositol Kinase   GO:0046854 phosphatidylinositol phosphorylation
Phosphatidylinositol Kinase   GO:0048015 phosphatidylinositol-mediated signaling

0 Parent Features

79 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0297987 Q9W4X4 Drosophila melanogaster
FBpp0303977 M9PDM4 Drosophila melanogaster
FBpp0072416 Q9W0R8 Drosophila melanogaster
FBpp0072417 Q9BKJ2 Drosophila melanogaster
FBpp0071973 Q9W1M7 Drosophila melanogaster
FBpp0083348 P91634 Drosophila melanogaster
FBpp0075819 Q7K3H0 Drosophila melanogaster
FBpp0276441 Q28ZE7 Drosophila pseudoobscura
FBpp0272772 Q29IN8 Drosophila pseudoobscura
FBpp0286694 Q29ER4 Drosophila pseudoobscura
FBpp0282585 Q29AY5 Drosophila pseudoobscura
FBpp0286905 Q29DX8 Drosophila pseudoobscura
FBpp0160790 B4KUT9 Drosophila mojavensis
FBpp0163618 B4L8F2 Drosophila mojavensis
FBpp0166489 B4KKU5 Drosophila mojavensis
FBpp0169714 B4KRZ1 Drosophila mojavensis
FBpp0171387 B4K8F9 Drosophila mojavensis
FBpp0173364 B4K7A2 Drosophila mojavensis
FBpp0225670 B4LCS5 Drosophila virilis
FBpp0233163 B4M219 Drosophila virilis
FBpp0233164 B4M218 Drosophila virilis
FBpp0236765 B4LLW5 Drosophila virilis
FBpp0237207 B4LVJ7 Drosophila virilis
FBpp0237869 B4LXA9 Drosophila virilis
FBpp0238707 B4LWM3 Drosophila virilis
FBpp0259315 B4P9P6 Drosophila yakuba
FBpp0261277 B4Q0Y3 Drosophila yakuba
FBpp0265190 B4PFP2 Drosophila yakuba
FBpp0266041 B4PC51 Drosophila yakuba
FBpp0270063 B4PPQ8 Drosophila yakuba