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Protein Domain : IPR000403

Name  Phosphatidylinositol 3-/4-kinase, catalytic domain Short Name  PI3/4_kinase_cat_dom
Type  Domain Description  Phosphatidylinositol 3-kinase (PI3-kinase) () []is an enzymethat phosphorylates phosphoinositides on the 3-hydroxyl group of the inositolring. The three products of PI3-kinase - PI-3-P,PI-3,4-P(2) and PI-3,4,5-P(3) function as secondary messengers in cell signalling.Phosphatidylinositol 4-kinase (PI4-kinase) () []is an enzymethat acts on phosphatidylinositol (PI) in the first committed step in theproduction of the secondary messenger inositol-1'4'5'-trisphosphate. This domain is also present in a wide range of protein kinases, involved in diverse cellular functions, such as control of cell growth, regulation of cell cycle progression, a DNA damage checkpoint, recombination, and maintenance of telomere length. Despite significant homology to lipid kinases, no lipid kinase activity has been demonstrated for any of the PIK-related kinases [].The PI3- and PI4-kinases share a well conserved domain at their C-terminalsection; this domain seems to be distantly related to the catalytic domain ofprotein kinases [, ]. The catalytic domain of PI3K has the typical bilobal structure that is seen in other ATP-dependentkinases, with a small N-terminal lobe and a large C-terminal lobe. The core of this domain is the most conserved region of the PI3Ks.The ATP cofactor binds in the crevice formed by the N-and C-terminal lobes, a loop between two strands providesa hydrophobic pocket for binding of the adenine moiety, and a lysine residue interactswith the alpha-phosphate. In contrast to protein kinases, the PI3K loop which interacts with thephosphates of the ATP and is known as the glycine-rich or P-loop, contains no glycine residues.Instead, contact with the ATP -phosphate is maintained through the side chain of a conserved serineresidue.

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site PI3/4_kinase_CS Conserved_site

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00454 PFAM IPR000403
PS50290 PROFILE IPR000403
SM00146 SMART IPR000403
G3DSA:1.10.1070.11 GENE3D IPR000403

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

4 Found In

DB identifier Name Short Name Type
IPR015433 Phosphatidylinositol Kinase PI_Kinase Family
IPR008290 Phosphatidylinositol 3-kinase, Vps34 type PI3K_Vps34 Family
IPR015519 ATM ATM Family
IPR022292 Conserved hypothetical protein CHP03843 CHP03843 Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Phosphatidylinositol 3-/4-kinase, catalytic domain   GO:0016773 phosphotransferase activity, alcohol group as acceptor

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Phosphatidylinositol 3-/4-kinase, catalytic domain   GO:0016773 phosphotransferase activity, alcohol group as acceptor

1 Parent Features

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain

170 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0297987 Q9W4X4 Drosophila melanogaster
FBpp0303977 M9PDM4 Drosophila melanogaster
FBpp0110174 Q5EAK6 Drosophila melanogaster
FBpp0080003 Q9VK45 Drosophila melanogaster
FBpp0307598 M9PFS0 Drosophila melanogaster
FBpp0074047 Q9VXG8 Drosophila melanogaster
FBpp0072416 Q9W0R8 Drosophila melanogaster
FBpp0072417 Q9BKJ2 Drosophila melanogaster
FBpp0071973 Q9W1M7 Drosophila melanogaster
FBpp0089178 Q9VND3 Drosophila melanogaster
FBpp0078404 Q8I0B7 Drosophila melanogaster
FBpp0083348 P91634 Drosophila melanogaster
FBpp0075819 Q7K3H0 Drosophila melanogaster
FBpp0070933 Q70PP2 Drosophila melanogaster
FBpp0292385 Q2EZ47 Drosophila melanogaster
FBpp0085431 Q8I8U7 Drosophila melanogaster
FBpp0276441 Q28ZE7 Drosophila pseudoobscura
FBpp0279570 B5DMV0 Drosophila pseudoobscura
FBpp0272772 Q29IN8 Drosophila pseudoobscura
FBpp0275668 B5DS99 Drosophila pseudoobscura
FBpp0286694 Q29ER4 Drosophila pseudoobscura
FBpp0301818 Q294C2 Drosophila pseudoobscura
FBpp0284413 Q296G2 Drosophila pseudoobscura
FBpp0300590 I5APC3 Drosophila pseudoobscura
FBpp0273660 Q29I80 Drosophila pseudoobscura
FBpp0275669 B5DS94 Drosophila pseudoobscura
FBpp0282585 Q29AY5 Drosophila pseudoobscura
FBpp0286905 Q29DX8 Drosophila pseudoobscura
FBpp0287697 Q29L62 Drosophila pseudoobscura
FBpp0160271 B4L7T5 Drosophila mojavensis