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Protein Domain : IPR011009

Name  Protein kinase-like domain Short Name  Kinase-like_dom
Type  Domain Description  Protein kinases () modify other proteins by chemically adding phosphate groups to them. This process is fundamental to most signalling and regulatory processes in the eukaryotic cell []. The protein kinases contain a catalytic core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold, which is found in enzymes that catalyse the formation of an amide bond. The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include:the catalytic domain of phosphoinositide-3-kinase (PI3K), which phosphorylates phosphoinositides and, as such, is involved in a number of fundamental cellular processes such as apoptosis, proliferation, motility and adhesion []choline kinase, which catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine []3',5'-aminoglycoside phosphotransferase type IIIa, a bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics []This entry represents the protein-kinase domain and other related domains that share a similar structure.

Publication Counts Displayer

7 Child Features

DB identifier Name Short Name Type
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain PI3/4_kinase_cat_dom Domain
IPR000719 Protein kinase domain Prot_kinase_dom Domain
IPR004166 MHCK/EF2 kinase MHCK_EF2_kinase Domain
IPR004147 UbiB domain UbiB_dom Domain
IPR015897 CHK kinase-like CHK_kinase-like Domain
IPR002575 Aminoglycoside phosphotransferase Aminoglycoside_PTrfase Domain
IPR015275 Actin-fragmin kinase, catalytic domain Actin-fragmin_kin_cat_dom Domain

10 Contains

DB identifier Name Short Name Type
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site PI3/4_kinase_CS Conserved_site
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR008271 Serine/threonine-protein kinase, active site Ser/Thr_kinase_AS Active_site
IPR008266 Tyrosine-protein kinase, active site Tyr_kinase_AS Active_site
IPR003527 Mitogen-activated protein (MAP) kinase, conserved site MAP_kinase_CS Conserved_site
IPR018935 RIO kinase, conserved site RIO_kinase_CS Conserved_site
IPR003605 TGF beta receptor, GS motif TGF_beta_rcpt_GS Domain
IPR002011 Tyrosine-protein kinase, receptor class II, conserved site Tyr_kinase_rcpt_2_CS Conserved_site
IPR001824 Tyrosine-protein kinase, receptor class III, conserved site Tyr_kinase_rcpt_3_CS Conserved_site
IPR007521 Choline kinase, N-terminal Choline_kin_N Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
SSF56112 SSF IPR011009

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

61 Found In

DB identifier Name Short Name Type
IPR015433 Phosphatidylinositol Kinase PI_Kinase Family
IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase Ca/CaM-dep_Ca-dep_prot_Kinase Family
IPR016232 cGMP-dependent protein kinase cGMP-dependent_protein_kinase Family
IPR002374 cGMP-dependent kinase cGMP_dep_kinase Family
IPR000239 GPCR kinase GPCR_kinase Family
IPR020766 Receptor-like tyrosine-protein kinase kin-15/kin-16 kin-15/kin-16 Family
IPR017407 Serine/threonine-protein kinase Rio1 Ser/Thr_kinase_Rio1 Family
IPR016247 Tyrosine-protein kinase, receptor ROR Tyr_kinase_rcpt_ROR Family
IPR020675 Myosin light chain kinase-related Myosin_light_ch_kinase-rel Family
IPR017184 Serine/threonine-protein kinase Unc-51 Ser/Thr_kinase_Unc51 Family
IPR017400 Elongation factor 2 kinase Elongation_factor_2_kinase Family
IPR017406 Serine/threonine-protein kinase Rio3 Ser/Thr_kinase_Rio3 Family
IPR008290 Phosphatidylinositol 3-kinase, Vps34 type PI3K_Vps34 Family
IPR002291 Phosphorylase kinase, gamma catalytic subunit Phosph_kin_gamma Family
IPR016257 Ephrin receptor type-A /type-B Tyr_kinase_ephrin_rcpt Family
IPR017164 Wee1-like protein kinase Wee1-like_protein_kinase Family
IPR021160 Mitogen-activated protein (MAP) kinase kinase kinase kinase MAPKKKK Family
IPR016248 Fibroblast growth factor receptor family FGF_rcpt_fam Family
IPR016235 Tyrosine/threonine-protein kinase, Cdc2 inhibitor Tyr/Thr_kinase_Cdc2_inhib Family
IPR020684 Rho-associated protein kinase Rho-assoc_coiled-coil_kin Family
IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2) VEGFR2_rcpt Family
IPR020691 Ephrin type-A receptor 8 EphrinA_rcpt8 Family
IPR016246 Tyrosine-protein kinase, insulin-like receptor Tyr_kinase_insulin-like_rcpt Family
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2 Tyr_kinase_non-rcpt_Jak/Tyk2 Family
IPR020693 Tyrosine-protein kinase, non-receptor Jak2 Tyr_kinase_non-rcpt_Jak2 Family
IPR020775 Tyrosine-protein kinase, non-receptor Jak3 Tyr_kinase_non-rcpt_Jak3 Family
IPR020776 Tyrosine-protein kinase, non-receptor Jak1 Tyr_kinase_non-rcpt_Jak1 Family
IPR020777 Tyrosine-protein kinase, neurotrophic receptor Tyr_kinase_NGF_rcpt Family
IPR020446 Tyrosine-protein kinase, neurotrophic receptor, type 3 Tyr_kin_neurotrophic_rcpt_3 Family
IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2 Tyr_kin_neurotrophic_rcpt_2 Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein kinase-like domain   GO:0016772 transferase activity, transferring phosphorus-containing groups

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein kinase-like domain   GO:0016772 transferase activity, transferring phosphorus-containing groups

0 Parent Features

5359 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0289022 Q8IML9 Drosophila melanogaster
FBpp0289025 Q86B72 Drosophila melanogaster
FBpp0289031 Q0KI03 Drosophila melanogaster
FBpp0289029 Q86B73 Drosophila melanogaster
FBpp0289021 P49762 Drosophila melanogaster
FBpp0289026 B7Z0R6 Drosophila melanogaster
FBpp0289020 A4V3J9 Drosophila melanogaster
FBpp0076820 Q94533 Drosophila melanogaster
FBpp0080736 Q27324 Drosophila melanogaster
FBpp0303242 M9PDD9 Drosophila melanogaster
FBpp0087908 Q7JQ36 Drosophila melanogaster
FBpp0087909 Q95U21 Drosophila melanogaster
FBpp0297987 Q9W4X4 Drosophila melanogaster
FBpp0303977 M9PDM4 Drosophila melanogaster
FBpp0111700 Q9VDJ9 Drosophila melanogaster
FBpp0084466 Q7KRY6 Drosophila melanogaster
FBpp0289408 Q8T4C5 Drosophila melanogaster
FBpp0072194 Q9W1B0 Drosophila melanogaster
FBpp0303422 M9PEF9 Drosophila melanogaster
FBpp0073578 Q23977 Drosophila melanogaster
FBpp0073579 M9PH06 Drosophila melanogaster
FBpp0304825 Q9VPW3 Drosophila melanogaster
FBpp0079769 Q9VKN7 Drosophila melanogaster
FBpp0083530 Q9VD82 Drosophila melanogaster
FBpp0099769 P32023 Drosophila melanogaster
FBpp0099944 P00528 Drosophila melanogaster
FBpp0292076 M9MRD8 Drosophila melanogaster
FBpp0083054 Q9VE58 Drosophila melanogaster
FBpp0075283 P16912 Drosophila melanogaster
FBpp0078437 Q7JWT4 Drosophila melanogaster