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Protein Domain : IPR000008

Name  C2 domain Short Name  C2_dom
Type  Domain Description  The C2 domain is a Ca2+-dependent membrane-targeting module found in many cellular proteins involved in signal transduction or membrane trafficking. C2 domains are unique among membrane targeting domains in that they show wide range of lipid selectivity for the major components of cell membranes, including phosphatidylserine and phosphatidylcholine. This C2 domain is about 116 amino-acid residues and is located between the two copies ofthe C1 domain in Protein Kinase C(that bind phorbol esters and diacylglycerol) (see )and the protein kinase catalytic domain (see ). Regions withsignificant homology []to the C2-domain have been found in many proteins.The C2 domain is thought to be involved in calcium-dependent phospholipidbinding []and in membrane targetting processes such as subcellular localisation. The 3D structure of theC2 domain of synaptotagmin has been reported[], the domain forms an eight-stranded beta sandwich constructed around a conserved 4-stranded motif, designated a C2 key []. Calcium binds ina cup-shaped depression formed by the N- and C-terminal loops of theC2-key motif. Structural analyses of several C2 domains have shown them to consist of similar ternary structures in which three Ca2+-binding loops are located at the end of an 8 stranded antiparallel beta sandwich.

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR002420 Phosphatidylinositol 3-kinase, C2 domain PI3K_C2_dom Domain
IPR014020 Tensin phosphatase, C2 domain Tensin_C2-dom Domain

1 Contains

DB identifier Name Short Name Type
IPR001565 Synaptotagmin Synaptotagmin Domain

6 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00168 PFAM IPR000008
PR00360 PRINTS IPR000008
PS50004 PROFILE IPR000008
SM00239 SMART IPR000008
G3DSA:2.60.40.150 GENE3D IPR000008
SSF49562 SSF IPR000008

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

11 Found In

DB identifier Name Short Name Type
IPR015427 Synaptotagmin 7 Synaptotagmin7 Family
IPR001192 Phosphoinositide phospholipase C family PI-PLC_fam Family
IPR015428 Synaptotagmin 1 Synaptotagmin1 Family
IPR014376 Protein kinase C, delta/epsilon/eta/theta types Prot_kin_PKC_delta Family
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma PLC-gamma Family
IPR014375 Protein kinase C, alpha/beta/gamma types Protein_kinase_C_a/b/g Family
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta PLC-beta Family
IPR011402 Phospholipase D, plant PLipase_D_pln Family
IPR017147 Tricalbin Tricalbin Family
IPR014638 Double C2 protein, alpha/beta/gamma type Doc2 Family
IPR014705 Synaptotagmin-17 SYT17 Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
C2 domain   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
C2 domain   GO:0005515 protein binding

0 Parent Features

807 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0075282 Q9VUV9 Drosophila melanogaster
FBpp0305807 M9PE32 Drosophila melanogaster
FBpp0305804 M9PDV6 Drosophila melanogaster
FBpp0089147 Q8IR23 Drosophila melanogaster
FBpp0076096 P48423 Drosophila melanogaster
FBpp0303201 M9PF62 Drosophila melanogaster
FBpp0079786 Q9VKJ9 Drosophila melanogaster
FBpp0087682 A1Z7T0 Drosophila melanogaster
FBpp0087683 A1Z7T1 Drosophila melanogaster
FBpp0087684 A1Z7T2 Drosophila melanogaster
FBpp0071431 Q9W2R9 Drosophila melanogaster
FBpp0086196 P13677 Drosophila melanogaster
FBpp0099675 Q7YTZ4 Drosophila melanogaster
FBpp0305708 E1JJB8 Drosophila melanogaster
FBpp0088306 Q9V483 Drosophila melanogaster
FBpp0111731 A8DYG9 Drosophila melanogaster
FBpp0293606 D3DMK5 Drosophila melanogaster
FBpp0086197 P05130 Drosophila melanogaster
FBpp0085772 Q0E919 Drosophila melanogaster
FBpp0085770 A1ZBH5 Drosophila melanogaster
FBpp0088307 Q8IM86 Drosophila melanogaster
FBpp0088305 Q8IM87 Drosophila melanogaster
FBpp0077495 Q9Y0H4 Drosophila melanogaster
FBpp0070619 P13217 Drosophila melanogaster
FBpp0076558 Q9VS57 Drosophila melanogaster
FBpp0290760 Q494I2 Drosophila melanogaster
FBpp0074387 Q9VWS3 Drosophila melanogaster
FBpp0071973 Q9W1M7 Drosophila melanogaster
FBpp0075708 Q9VTY0 Drosophila melanogaster
FBpp0310756 Q9VFG8 Drosophila melanogaster