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Gene : Trpml D. melanogaster

DB identifier  ? FBgn0262516 Secondary Identifier  ? CG8743
Name  ? Transient receptor potential cation channel, mucolipin ortholog Source  FlyBase
  • synonyms:
  • FBgn0036904,
  • FBan0008743,
  • transient receptor potential mucolipin,
  • CT25240,
  • CG8743,
  • TRP Mucolipin,
  • TRPML,
  • FBgn0084940,
  • DmTRPML,
  • FBgn0262516,
  • l(3)76BDi

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17 Alleles

DB identifier Symbol Allele Class Organism
FBal0245730 Trpml[JF01466]   Drosophila melanogaster
FBal0281017 Trpml[MI06307]   Drosophila melanogaster
FBal0184751 Trpml[c05523]   Drosophila melanogaster
FBal0221784 Trpml[+tVa]   Drosophila melanogaster
FBal0205978 Trpml[GD555]   Drosophila melanogaster
FBal0221785 Trpml[Scer\UAS.cVa]   Drosophila melanogaster
FBal0230910 Trpml[KK100774]   Drosophila melanogaster
FBal0191265 Trpml[76BDi-2]   Drosophila melanogaster
FBal0221783 Trpml[2]   Drosophila melanogaster
FBal0219687 Trpml[6]   Drosophila melanogaster
FBal0221782 Trpml[1] amorphic allele - genetic evidence Drosophila melanogaster
FBal0221781 Trpml[GE22279]   Drosophila melanogaster
FBal0194313 Trpml[dsRNA.cRa]   Drosophila melanogaster
FBal0160895 Trpml[PL00182]   Drosophila melanogaster
FBal0245531 Trpml[JF01239]   Drosophila melanogaster
FBal0278272 Trpml[Scer\UAS.T:Hsap\MYC]   Drosophila melanogaster
FBal0184750 Trpml[c05571]   Drosophila melanogaster

46 Clones

Secondary Identifier DB identifier
EP19364 FBcl0079533
EK140501 FBcl0137322
EK050443 FBcl0137330
EK112923 FBcl0137336
LD22993 FBcl0166255
RE15656 FBcl0201495
RE15859 FBcl0201496
RE73779 FBcl0201497
RE04470 FBcl0201499
RE68625 FBcl0201512
RE24195 FBcl0201517
RE63487 FBcl0201518
RE35813 FBcl0201524
Dmel_dig_015204_0655_2588 FBcl0382985
CK01.67B.E8 FBcl0451042
CK01.62C.C6 FBcl0451051
RP003286441 FBcl0691525
RP003335632 FBcl0691523
RP003211056 FBcl0691524
RP003332117 FBcl0691526
RP003617605 FBcl0691527
RP003183190 FBcl0691529
RP003424398 FBcl0691534
RP003421801 FBcl0691535
RP003535920 FBcl0691536
RP003113279 FBcl0691538
RP003210917 FBcl0691539
RP003113210 FBcl0691541
RP003436547 FBcl0691542
RP003187200 FBcl0691543

3 Exons

DB identifier Symbol
FBgn0262516:3 trpml:3
FBgn0262516:2 trpml:2
FBgn0262516:1 trpml:1

1 Transcripts

DB identifier Gene
FBtr0074952 Trpml

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0074952-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0074952-3-prime-utr Drosophila melanogaster

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3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
40152, 8673965 NCBI Entrez Gene identifiers FBgn0262516
40152 NCBI Entrez Gene identifiers FBgn0262516
65421 BioGRID FBgn0262516

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  

0 Expression Scores

2 Introns

DB identifier
Organism . Name
intron_FBgn0262516:3_FBgn0262516:2 Drosophila melanogaster
intron_FBgn0262516:2_FBgn0262516:1 Drosophila melanogaster

26 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Trpml none 0.351068611   19067489
Lipid storage Trpml none -1.654324396   19067489
Lipid storage Trpml none 0.784289477   19067489
ERK signaling Trpml ERK activation reduced weak   17086199
Intracellular Listeria monocytogenes infection Trpml Decreased GFP protein expression moderate   16020693
Mycobacterial infection (1) - M. fortuitum infection Trpml Decreased M. fortuitum intracellular infection 2.3 measurement after 3 days 16020694
Cell size and cell-cycle regulation (1) Trpml none sp   16496002
Store-operated calcium influx regulation Trpml none np   15866891
M. smegmatis infection Trpml Increased M. smegmatis infection np   18287038
Muscle morphogenesis and function (1) Trpml Lethal np   20220848
Heat nociception (1) Trpml Developmentally lethal 0   21074052
Heart development and function (1) Trpml none 1   20371351
Heart development and function (2) Trpml none 2.22   20371351
Serratia marcescens infection (1) Trpml none -1.44705882352941   19520911
Notch pathway regulation (4) Trpml Gain of bristles, lateral inhibition sp   19363474
Notch pathway regulation (4) Trpml Gain of bristles, notum malformation death, lateral inhibition sp   19363474
Notch pathway regulation (5) Trpml Bent up (spoon-shaped) wing np   19363474
Notch pathway regulation (5) Trpml Bent up (spoon-shaped) wing or lethal, larger wings np   19363474
Notch pathway regulation (6) Trpml none np   19363474
Muscle assembly and maintenance Trpml Muscles with short and/or thin myofibrils severe   18359903
Adiposity regulation (1) Trpml none 0.06   20074523
RTK-Ras-ERK pathway regulation (1) Trpml none 0.19 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Trpml none -0.18 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Trpml none -0.33 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Trpml none 0.02 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation Trpml none 0.03   23263283

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