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Protein : FBpp0088783 D. melanogaster

Primary Accession  ? Q86BE9 Organism . Name  Drosophila melanogaster
MD5 Checksum  5d255956c363c58b1c18815c91ea1a82 UniProt Accession  Q86BE9
UniProt Name  PEN2_DROME GenBank Identifier  AAO41356
Is UniProt Canonical  true Is Fragment  false
Length  101 Molecular Weight  11725
Name  Gamma-secretase subunit pen-2 Secondary Identifier  FBpp0088783

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1 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0053198 CG33198 pen-2 presenilin enhancer FlyBase D. melanogaster


Protein --> Gene + chromosomal location and length of the gene.


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0 Components

2 Cross References

Source . Name

Subject . Primary Identifier
Dm.14392 UniGene FBpp0088783
NP_788401.2 RefSeq FBpp0088783

3 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set
Reactome data set  

0 Ec Numbers

2 Locations

Located On . Primary Identifier
Start End Strand
2R 14165126 14165571 1
2R 14165126 14165571 1

24 Pathways

Identifier Name
154437 Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
120472 Signaling by NOTCH4
162718 Signaling by NOTCH1 HD Domain Mutants in Cancer
162388 Signaling by NOTCH1 PEST Domain Mutants in Cancer
163048 Constitutive Signaling by NOTCH1 PEST Domain Mutants
162365 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
162987 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
162349 FBXW7 Mutants and NOTCH1 in Cancer
162508 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
158569 A third proteolytic cleavage releases NICD
162622 Signaling by NOTCH1 in Cancer
118381 Disease
120403 Signaling by NOTCH3
162544 NOTCH2 Activation and Transmission of Signal to the Nucleus
118415 Signaling by ERBB4
144143 Nuclear signaling by ERBB4
120586 Signaling by NOTCH2
120524 Signaling by NOTCH1
120582 Activated NOTCH1 Transmits Signal to the Nucleus
152825 Pre-NOTCH Processing in the Endoplasmic Reticulum
120528 Pre-NOTCH Processing in Golgi
78520 Signaling by NOTCH
120456 Pre-NOTCH Expression and Processing
97910 Signaling Pathways

1 Protein Domains

DB identifier Name Short Name Type
IPR019379 Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit Gamma_Secretase_Asp_P_PEN2 Family

2 Transcripts

DB identifier Gene
FBtr0340331 pen-2
FBtr0089842 pen-2