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Protein : FBpp0084083 D. melanogaster

Primary Accession  ? Q9VC27 Organism . Name  Drosophila melanogaster
MD5 Checksum  9c3b0f1623af686523a690ea34c084cd UniProt Accession  Q9VC27
UniProt Name  NICA_DROME GenBank Identifier  ACZ95007
Is UniProt Canonical  true Is Fragment  false
Length  695 Molecular Weight  77993
Name  Nicastrin Secondary Identifier  FBpp0084083

Publication Counts Displayer

Uni Prot Comments Displayer

Protein Sequence Displayer


1 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0039234 CG7012 nct nicastrin FlyBase D. melanogaster


Protein --> Gene + chromosomal location and length of the gene.


Cytoscape Network Displayer



0 Components

3 Cross References

Source . Name

Subject . Primary Identifier
NP_651297.2 RefSeq FBpp0084083
NP_001163713.1 RefSeq FBpp0084083
Dm.3407 UniGene FBpp0084083

3 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set
Reactome data set  

0 Ec Numbers

2 Locations

Located On . Primary Identifier
Start End Strand
3R 20677371 20679956 1
3R 20677371 20679956 1

24 Pathways

Identifier Name
154437 Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
120472 Signaling by NOTCH4
162718 Signaling by NOTCH1 HD Domain Mutants in Cancer
162388 Signaling by NOTCH1 PEST Domain Mutants in Cancer
163048 Constitutive Signaling by NOTCH1 PEST Domain Mutants
162365 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
162987 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
162349 FBXW7 Mutants and NOTCH1 in Cancer
162508 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
158569 A third proteolytic cleavage releases NICD
162622 Signaling by NOTCH1 in Cancer
118381 Disease
120403 Signaling by NOTCH3
162544 NOTCH2 Activation and Transmission of Signal to the Nucleus
118415 Signaling by ERBB4
144143 Nuclear signaling by ERBB4
120586 Signaling by NOTCH2
120524 Signaling by NOTCH1
120582 Activated NOTCH1 Transmits Signal to the Nucleus
152825 Pre-NOTCH Processing in the Endoplasmic Reticulum
120528 Pre-NOTCH Processing in Golgi
78520 Signaling by NOTCH
120456 Pre-NOTCH Expression and Processing
97910 Signaling Pathways

1 Protein Domains

DB identifier Name Short Name Type
IPR008710 Nicastrin Nicastrin Family

2 Transcripts

DB identifier Gene
FBtr0084705 nct
FBtr0301865 nct