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Protein : FBpp0070483 D. melanogaster

Primary Accession  ? P07207 Organism . Name  Drosophila melanogaster
MD5 Checksum  eb325d68765649f3755c5a72e1db32ce UniProt Accession  P07207
UniProt Name  NOTCH_DROME GenBank Identifier  AAF45848
Is UniProt Canonical  true Is Fragment  false
Length  2703 Molecular Weight  288853
Name  Neurogeniclocus Notch protein Secondary Identifier  FBpp0070483

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Genomics

1 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0004647 CG3936 N Notch FlyBase D. melanogaster

Proteins

Protein --> Gene + chromosomal location and length of the gene.

Interactions

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Other

1 Components

Name
Processed neurogenic locus Notch protein

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
NP_476859.2 RefSeq FBpp0070483
Dm.4702 UniGene FBpp0070483
NP_001245510.1 RefSeq FBpp0070483

3 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Reactome data set  

0 Ec Numbers

2 Locations


Located On . Primary Identifier
Start End Strand
X 3029701 3065011 1
X 3029701 3065011 1

30 Pathways

Identifier Name
154437 Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
120472 Signaling by NOTCH4
113552 Developmental Biology
162615 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
162718 Signaling by NOTCH1 HD Domain Mutants in Cancer
162275 Constitutive Signaling by NOTCH1 HD Domain Mutants
162388 Signaling by NOTCH1 PEST Domain Mutants in Cancer
163048 Constitutive Signaling by NOTCH1 PEST Domain Mutants
162365 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
162987 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
162349 FBXW7 Mutants and NOTCH1 in Cancer
162508 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
162685 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
109180 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
93479 Regulation of beta-cell development
158569 A third proteolytic cleavage releases NICD
162622 Signaling by NOTCH1 in Cancer
118381 Disease
120403 Signaling by NOTCH3
162544 NOTCH2 Activation and Transmission of Signal to the Nucleus
120634 NOTCH1 Intracellular Domain Regulates Transcription
120586 Signaling by NOTCH2
120524 Signaling by NOTCH1
120582 Activated NOTCH1 Transmits Signal to the Nucleus
152825 Pre-NOTCH Processing in the Endoplasmic Reticulum
120528 Pre-NOTCH Processing in Golgi
78520 Signaling by NOTCH
120456 Pre-NOTCH Expression and Processing
97910 Signaling Pathways
84305 NICD traffics to nucleus

13 Protein Domains

DB identifier Name Short Name Type
IPR002110 Ankyrin repeat Ankyrin_rpt Repeat
IPR020683 Ankyrin repeat-containing domain Ankyrin_rpt-contain_dom Domain
IPR000742 Epidermal growth factor-like domain EG-like_dom Domain
IPR013032 EGF-like, conserved site EGF-like_CS Conserved_site
IPR001881 EGF-like calcium-binding domain EGF-like_Ca-bd_dom Domain
IPR000152 EGF-type aspartate/asparagine hydroxylation site EGF-type_Asp/Asn_hydroxyl_site PTM
IPR018097 EGF-like calcium-binding, conserved site EGF_Ca-bd_CS Conserved_site
IPR000800 Notch domain Notch_dom Domain
IPR010660 Notch, NOD domain Notch_NOD_dom Domain
IPR011656 Notch, NODP domain Notch_NODP_dom Domain
IPR009030 Insulin-like growth factor binding protein, N-terminal Growth_fac_rcpt_N_dom Domain
IPR024600 Domain of unknown function DUF3454, notch DUF3454_notch Domain
IPR008297 Notch Notch Family

2 Transcripts

DB identifier Gene
FBtr0070507 N
FBtr0304659 N