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Protein : FBpp0307126 D. melanogaster

Primary Accession  ? Q9VQG2 Organism . Name  Drosophila melanogaster
MD5 Checksum  9daf259982dceb86523650e0346b230f UniProt Accession  Q9VQG2
UniProt Name  APH1_DROME GenBank Identifier  AGB92500
Is UniProt Canonical  true Is Fragment  false
Length  238 Molecular Weight  26437
Name  Gamma-secretase subunit Aph-1 Secondary Identifier  FBpp0307126

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1 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0031458 CG2855 aph-1 anterior pharynx defective 1 FlyBase D. melanogaster


Protein --> Gene + chromosomal location and length of the gene.


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0 Components

3 Cross References

Source . Name

Subject . Primary Identifier
NP_608710.1 RefSeq FBpp0307126
Dm.19771 UniGene FBpp0307126
NP_001259963.1 RefSeq FBpp0307126

3 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set
Reactome data set  

0 Ec Numbers

2 Locations

Located On . Primary Identifier
Start End Strand
2L 2766315 2767087 1
2L 2766315 2767087 1

24 Pathways

Identifier Name
154437 Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
120472 Signaling by NOTCH4
162718 Signaling by NOTCH1 HD Domain Mutants in Cancer
162388 Signaling by NOTCH1 PEST Domain Mutants in Cancer
163048 Constitutive Signaling by NOTCH1 PEST Domain Mutants
162365 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
162987 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
162349 FBXW7 Mutants and NOTCH1 in Cancer
162508 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
158569 A third proteolytic cleavage releases NICD
162622 Signaling by NOTCH1 in Cancer
118381 Disease
120403 Signaling by NOTCH3
162544 NOTCH2 Activation and Transmission of Signal to the Nucleus
118415 Signaling by ERBB4
144143 Nuclear signaling by ERBB4
120586 Signaling by NOTCH2
120524 Signaling by NOTCH1
120582 Activated NOTCH1 Transmits Signal to the Nucleus
152825 Pre-NOTCH Processing in the Endoplasmic Reticulum
120528 Pre-NOTCH Processing in Golgi
78520 Signaling by NOTCH
120456 Pre-NOTCH Expression and Processing
97910 Signaling Pathways

1 Protein Domains

DB identifier Name Short Name Type
IPR009294 Gamma-secretase subunit Aph-1 Aph-1 Family

2 Transcripts

DB identifier Gene
FBtr0077716 aph-1
FBtr0335127 aph-1