modENCODE |  Help |  blog

Gene : Rpb8 D. melanogaster

DB identifier  ? FBgn0037121 Secondary Identifier  ? CG11246
Name  ? Rpb8 Source  FlyBase
  • synonyms:
  • CG11246,
  • FBgn0037121,
  • RPB8,
  • FBan0011246

Sequence Feature Displayer

Publication Counts Displayer

Genomics

Gene Ontology Displayer

Homologue Displayer

Mod Mine G Browse Displayer

Overlapping Features Displayer

Regulatory Regions Displayer

4 Alleles

DB identifier Symbol Allele Class Organism
FBal0287263 Rpb8[Scer\UAS.ORF]   Drosophila melanogaster
FBal0270791 Rpb8[NIG.11246R]   Drosophila melanogaster
FBal0208402 Rpb8[GD4221]   Drosophila melanogaster
FBal0236072 Rpb8[KK109127]   Drosophila melanogaster

110 Clones

Secondary Identifier DB identifier
DPiM_GM03174 FBcl0740842
bs22h04 FBcl0052773
EK270043 FBcl0112106
EK234342 FBcl0112164
EK244755 FBcl0112172
EK124849 FBcl0112180
EK292942 FBcl0112186
GM03174 FBcl0142023
LP23851 FBcl0187337
EC056322 FBcl0303471
EC056164 FBcl0303472
EC053645 FBcl0303473
EC051654 FBcl0303474
EC053651 FBcl0303475
Dmel_neb_013646_0694_2567 FBcl0383245
147322 FBcl0449933
RP004506463 FBcl0698836
RP004446684 FBcl0698834
RP004438067 FBcl0698843
RP004528492 FBcl0698831
RP004249891 FBcl0698832
RP004356331 FBcl0698833
RP004235806 FBcl0698835
RP004169178 FBcl0698837
RP004242603 FBcl0698838
RP004382310 FBcl0698839
RP004253398 FBcl0698840
RP004451705 FBcl0698841
RP004425318 FBcl0698842
RP004519504 FBcl0698844

2 Exons

DB identifier Symbol
FBgn0037121:1 Rpb8:1
FBgn0037121:2 Rpb8:2

1 Transcripts

DB identifier Gene
FBtr0078432 Rpb8

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0078432-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0078432-3-prime-utr Drosophila melanogaster

Interactions

Cytoscape Network Displayer

 

Other

42 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
40415 NCBI Entrez Gene identifiers FBgn0037121
65656 BioGRID FBgn0037121

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 517.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 476.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 90.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 255.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 204.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 315.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 281.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 248.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 317.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 262.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 188.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 208.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 284.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 408.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 141.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 431.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 197.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 290.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 383.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 413.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 196.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 634.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 392.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 269.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 197.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 420.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 228.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 400.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 537.0
FBgn0037121 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 752.0

1 Introns

DB identifier
Organism . Name
intron_FBgn0037121:1_FBgn0037121:2 Drosophila melanogaster

32 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Rpb8 none -0.012082722   19067489
Lipid storage Rpb8 none 1.319394596   19067489
Lipid storage Rpb8 none -0.453685767   19067489
ERK signaling Rpb8 ERK activation increased weak   17086199
Constitutive protein secretion and Golgi organization (1) Rpb8 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Rpb8 none sp   16496002
Combinatorial effect with methyl methanesulphonate (1) Rpb8 Synthetic lethal with methyl methanesulphonate sp   19543366
Combinatorial effect with methyl methanesulphonate (2) Rpb8 Synthetic lethal with methyl methanesulphonate sp   19543366
Mutant human huntingtin aggregation Rpb8 Decreased mutant human huntingtin aggregation <= -2   19789644
Muscle morphogenesis and function (1) Rpb8 Lethal np   20220848
Muscle morphogenesis and function (2) Rpb8 Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Muscle morphogenesis and function (3) Rpb8 none np   20220848
Heat nociception (1) Rpb8 none -1.17   21074052
Heart development and function (1) Rpb8 none 1   20371351
Serratia marcescens infection (1) Rpb8 none 0.6   19520911
Notch pathway regulation (4) Rpb8 Completely lethal (before pupal) sp   19363474
G2-M DNA damage checkpoint regulation (2) Rpb8 Increased histone H3 phosphorylation with bleocin 38.09 with bleocin 21205937
G2-M DNA damage checkpoint regulation (2) Rpb8 Increased histone H3 phosphorylation with doxorubicin 58.63 with doxorubicin 21205937
G2-M DNA damage checkpoint regulation (2) Rpb8 Increased histone H3 phosphorylation with etoposide 45.74 with etoposide 21205937
G2-M DNA damage checkpoint regulation (2) Rpb8 Increased histone H3 phosphorylation after X-ray exposure 69.4 X-ray exposure 21205937
Notch pathway regulation (1) Rpb8 Downregulation of Notch pathway np   20493818
Notch pathway regulation (2) Rpb8 Lethal strong en-GAL4 20493818
Notch pathway regulation (2) Rpb8 Downregulation of Notch pathway; adult wing margin: notches sp C96-GAL4 20493818
Notch pathway regulation (3) Rpb8 none np   20493818
Adiposity regulation (1) Rpb8 none 0.353   20074523
RTK-Ras-ERK pathway regulation (1) Rpb8 Decreased ERK phosphorylation after EGF stimulation -1.84 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Rpb8 none -1 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Rpb8 none 1.43 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Rpb8 Increased ERK phosphorylation after sSpitz and EGF stimulation 2.47 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation Rpb8 none 0.65   23263283

0 Submissions