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Gene : ik2 D. melanogaster

DB identifier  ? FBgn0086657 Secondary Identifier  ? CG2615
Name  ? IkappaB kinase-like 2 Source  FlyBase
  • synonyms:
  • FBgn0028633,
  • IK2,
  • Dmik2,
  • FBgn0086657,
  • FBan0002615,
  • apoptoxin 7,
  • CG2615,
  • DIK2,
  • 38D.31,
  • dIKK,
  • DmIKKepsilon,
  • IKK-related kinase,
  • Ik2/DmIKK,
  • IkappaB kinase-like 2,
  • IKKepsilon,
  • APTX7,
  • FBgn0043071,
  • DmIKKepsilon/dIK2,
  • lethal (2) 38Ea,
  • FBgn0025164,
  • l(2)38Ea,
  • IKK

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31 Alleles

DB identifier Symbol Allele Class Organism
FBal0179421 ik2[e01853]   Drosophila melanogaster
FBal0257846 ik2[HMS01188]   Drosophila melanogaster
FBal0249079 ik2[Scer\UAS.P\T.T:Avic\GFP-EGFP]   Drosophila melanogaster
FBal0196643 ik2[D160N.Scer\UAS.T:Hsap\MYC]   Drosophila melanogaster
FBal0196645 ik2[DeltaUbl.Scer\UAS.T:Hsap\MYC]   Drosophila melanogaster
FBal0196640 ik2[Scer\UAS.cKa]   Drosophila melanogaster
FBal0196641 ik2[hs.PK]   Drosophila melanogaster
FBal0196642 ik2[G19R.Scer\UAS.T:Hsap\MYC]   Drosophila melanogaster
FBal0196644 ik2[G250D.Scer\UAS.T:Hsap\MYC]   Drosophila melanogaster
FBal0091357 ik2[2]   Drosophila melanogaster
FBal0091356 ik2[3]   Drosophila melanogaster
FBal0091358 ik2[1]   Drosophila melanogaster
FBal0091355 ik2[4]   Drosophila melanogaster
FBal0091354 ik2[5] loss of function allele Drosophila melanogaster
FBal0196649 ik2[alice]   Drosophila melanogaster
FBal0144231 ik2[dsRNA.cSa]   Drosophila melanogaster
FBal0262637 ik2[GL00160]   Drosophila melanogaster
FBal0240086 ik2[MB11506]   Drosophila melanogaster
FBal0287304 ik2[Scer\UAS.ORF]   Drosophila melanogaster
FBal0287305 ik2[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0194837 ik2[Scer\UAS.T:Hsap\MYC]   Drosophila melanogaster
FBal0194838 ik2[Scer\UAS.T:Ivir\HA1]   Drosophila melanogaster
FBal0194832 ik2[dsRNA.Scer\UAS]   Drosophila melanogaster
FBal0194833 ik2[MtnA.PO]   Drosophila melanogaster
FBal0194829 ik2[GS11377]   Drosophila melanogaster
FBal0194830 ik2[Scer\UAS.cOa]   Drosophila melanogaster
FBal0194831 ik2[DN.Scer\UAS]   Drosophila melanogaster
FBal0194839 ik2[Ubi-p63E.PO]   Drosophila melanogaster
FBal0209725 ik2[GD5424]   Drosophila melanogaster
FBal0231782 ik2[KK102408]   Drosophila melanogaster

26 Clones

Secondary Identifier DB identifier
ESG0114a.B21_G06 FBcl0007243
EK262436 FBcl0084434
EK187263 FBcl0084486
EK224137 FBcl0084838
GH07508 FBcl0113167
GM18862 FBcl0145423
RE37485 FBcl0207025
SD10041 FBcl0281125
EC056333 FBcl0301487
EC052500 FBcl0301484
EC053983 FBcl0301485
EC053530 FBcl0301486
FGC012B04 FBcl0385152
FGC012B09 FBcl0385154
FI05319 FBcl0481425
RP004253987 FBcl0614029
RP004260894 FBcl0614030
RP004239161 FBcl0614031
RP004254338 FBcl0614032
RP004231541 FBcl0614033
RP004263010 FBcl0614034
RP004501742 FBcl0614035
97959 FBcl0407132
118155 FBcl0407137
61650 FBcl0407145
159643 FBcl0407190

8 Exons

DB identifier Symbol
FBgn0086657:3 ik2:3
FBgn0086657:4 ik2:4
FBgn0086657:5 ik2:5
FBgn0086657:6 ik2:6
FBgn0086657:7 ik2:7
FBgn0086657:8 ik2:8
FBgn0086657:1 ik2:1
FBgn0086657:2 ik2:2

2 Transcripts

DB identifier Gene
FBtr0081390 ik2
FBtr0336824 ik2

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0081390-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0336824-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0081390-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0336824-3-prime-utr Drosophila melanogaster

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Other

0 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
35329 NCBI Entrez Gene identifiers FBgn0086657
61292 BioGRID FBgn0086657

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 415.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 315.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 496.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 326.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 488.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 222.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 321.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 387.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 144.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 951.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 348.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 303.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 335.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 212.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 376.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 252.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 578.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 382.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 415.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 396.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 374.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 372.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 504.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 469.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 557.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1002.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 479.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 551.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 538.0
FBgn0086657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 420.0

7 Introns

DB identifier
Organism . Name
intron_FBgn0086657:3_FBgn0086657:4 Drosophila melanogaster
intron_FBgn0086657:4_FBgn0086657:5 Drosophila melanogaster
intron_FBgn0086657:5_FBgn0086657:6 Drosophila melanogaster
intron_FBgn0086657:6_FBgn0086657:7 Drosophila melanogaster
intron_FBgn0086657:7_FBgn0086657:8 Drosophila melanogaster
intron_FBgn0086657:1_FBgn0086657:2 Drosophila melanogaster
intron_FBgn0086657:2_FBgn0086657:4 Drosophila melanogaster

33 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage ik2 none 1.126856363   19067489
Lipid storage ik2 none 3.600062576   19067489
Cell cycle regulation (1) ik2 All mitotic defects, spindle defects sp   15616552
Cell cycle regulation (2) ik2 none np   15616552
Cell size and cell-cycle regulation (1) ik2 Increased G2 DNA content sp   16496002
Cell size and cell-cycle regulation (1) ik2 none sp   16496002
Cell size and cell-cycle regulation (1) ik2 none sp   16496002
Cell size and cell-cycle regulation (2) ik2 none 1.309   16496002
Cell size and cell-cycle regulation (3) ik2 none 453   16496002
Muscle morphogenesis and function (1) ik2 none np   20220848
Muscle morphogenesis and function (1) ik2 Weak flyer np   20220848
Muscle morphogenesis and function (1) ik2 none np   20220848
Heat nociception (1) ik2 none 0.07   21074052
Heat nociception (1) ik2 none -1.17   21074052
Heart development and function (1) ik2 none 1   20371351
Serratia marcescens infection (1) ik2 none 0.411111111111111   19520911
Serratia marcescens infection (1) ik2 none -0.443298969072164   19520911
Notch pathway regulation (4) ik2 Loss of bristles, bristle morphology defects, notum malformation death sp   19363474
Notch pathway regulation (4) ik2 none 0   19363474
Notch pathway regulation (4) ik2 Bristle morphology defects 9   19363474
PGN-induced dJNK phosphorylation ik2 Increased P-JNK protein expression with PGN 2.99 60 min PGN induction 19893628
PGN-induced dJNK phosphorylation ik2 Increased P-JNK protein expression with PGN 2.22 15 min PGN induction 19893628
Adiposity regulation (1) ik2 none 0.165   20074523
Adiposity regulation (1) ik2 none 0.292   20074523
Actin organization and cell morphology (1) ik2 none np   19265526
Actin organization and cell morphology (2) ik2 none np   19265526
Actin organization and cell morphology (3) ik2 none np   19265526
Actin organization and cell morphology (4) ik2 Altered cell morphology np   19265526
Actin organization and cell morphology (5) ik2 none np   19265526
Actin organization and cell morphology (6) ik2 Altered cell morphology np   19265526

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