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Gene : Tif-IA D. melanogaster
DB identifier  ? FBgn0032988 Secondary Identifier  ? CG3278
Name  ? Tif-IA Source  FlyBase
  • synonyms:
  • CG5951,
  • FBgn0032988,
  • TIF-1A,
  • TIF-IA,
  • CG16938,
  • FBgn0032989,
  • CG3278,
  • FBan0003278,
  • FBgn0032990,
  • dTIF-IA,
  • TifIA
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Genomics

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7 Alleles

DB identifier Symbol Allele Class Organism
FBal0181271 Tif-IA[f03212]   Drosophila melanogaster
FBal0243443 Tif-IA[Scer\UAS.cGa]   Drosophila melanogaster
FBal0243444 Tif-IA[dsRNA.Scer\UAS]   Drosophila melanogaster
FBal0147360 Tif-IA[KG06857]   Drosophila melanogaster
FBal0262854 Tif-IA[GL00388]   Drosophila melanogaster
FBal0208780 Tif-IA[GD9239]   Drosophila melanogaster
FBal0231911 Tif-IA[KK102641]   Drosophila melanogaster

91 Clones

Secondary Identifier DB identifier
DPiM_LD10456 FBcl0741426
EK286527 FBcl0029560
EK042349 FBcl0029894
EK222038 FBcl0029928
EK260323 FBcl0029962
EK254552 FBcl0029998
EK123541 FBcl0028022
EK152705 FBcl0028120
EK261353 FBcl0028180
EK142020 FBcl0028202
EK113417 FBcl0028268
EK182339 FBcl0028288
EK173239 FBcl0028330
EK198630 FBcl0028370
EK182506 FBcl0028394
EK054331 FBcl0028422
EK216111 FBcl0028478
EK112562 FBcl0028652
EC22044 FBcl0068951
EC26969 FBcl0068953
EP20050 FBcl0078009
EP10432 FBcl0084111
GM04776 FBcl0142238
GM10313 FBcl0142241
GM10316 FBcl0142242
LD10456 FBcl0154882
LP10980 FBcl0183399
RE50029 FBcl0207494
RE48679 FBcl0207504
RE47831 FBcl0207532

8 Exons

DB identifier Symbol
FBgn0032988:1 Tif-IA:1
FBgn0032988:2 Tif-IA:2
FBgn0032988:4 Tif-IA:4
FBgn0032988:6 Tif-IA:6
FBgn0032988:7 Tif-IA:7
FBgn0032988:8 Tif-IA:8
FBgn0032988:3 Tif-IA:3
FBgn0032988:5 Tif-IA:5

2 Transcripts

DB identifier Gene
FBtr0085955 Tif-IA
FBtr0331294 Tif-IA

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0085955-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0085955-3-prime-utr Drosophila melanogaster

Interactions

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Other

7 Pathways

2 Cross References

Identifier
Source . Name
Subject . Primary Identifier
35454 NCBI Entrez Gene identifiers FBgn0032988
61392 BioGRID FBgn0032988

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier
Submission . Title
Cell Line . Name
Developmental Stage . Name 		Score
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 2028.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1917.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 1592.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1178.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1489.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1185.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1087.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1817.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1697.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 2219.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1734.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1279.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1016.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1058.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1469.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 1187.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1072.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 1349.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 2138.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1622.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1529.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1441.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1368.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 2426.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 2691.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 3740.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 1605.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1168.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1773.0
FBgn0032988 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1639.0

8 Introns

DB identifier
Organism . Name
intron_FBgn0032988:1_FBgn0032988:2 Drosophila melanogaster
intron_FBgn0032988:2_FBgn0032988:4 Drosophila melanogaster
intron_FBgn0032988:4_FBgn0032988:6 Drosophila melanogaster
intron_FBgn0032988:6_FBgn0032988:7 Drosophila melanogaster
intron_FBgn0032988:7_FBgn0032988:8 Drosophila melanogaster
intron_FBgn0032988:2_FBgn0032988:3 Drosophila melanogaster
intron_FBgn0032988:3_FBgn0032988:5 Drosophila melanogaster
intron_FBgn0032988:5_FBgn0032988:6 Drosophila melanogaster

32 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Tif-IA none -0.478854485   19067489
Lipid storage Tif-IA none -2.890729507   19067489
Lipid storage Tif-IA none -0.077043925   19067489
Lipid storage Tif-IA none -1.030399474   19067489
ERK signaling Tif-IA ERK activation increased weak   17086199
Hedgehog signaling Tif-IA Decreased Hedgehog reporter activity -2.29   16311596
Hedgehog signaling Tif-IA Decreased Hedgehog reporter activity -2.42   16311596
Cell size and cell-cycle regulation (1) Tif-IA none sp   16496002
Dendrite pattern formation Tif-IA none np   16547170
Muscle morphogenesis and function (1) Tif-IA Lethal np   20220848
Muscle morphogenesis and function (1) Tif-IA Lethal np   20220848
Muscle morphogenesis and function (2) Tif-IA Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Muscle morphogenesis and function (3) Tif-IA none np   20220848
Heat nociception (1) Tif-IA Developmentally lethal 0   21074052
Heat nociception (1) Tif-IA Developmentally lethal -1.17   21074052
Heart development and function (1) Tif-IA Embryonic lethal or no offspring 0   20371351
Heart development and function (1) Tif-IA Adult lethal 0   20371351
Notch pathway regulation (4) Tif-IA Notum malformation death 10   19363474
Notch pathway regulation (4) Tif-IA Notum malformation death 10   19363474
Hh pathway regulation Tif-IA Downregulation of Hh pathway -0.345312951151702   17903264
Hh pathway regulation Tif-IA none -0.208466043380552   17903264
Notch pathway regulation (1) Tif-IA Downregulation of Notch pathway np   20493818
Notch pathway regulation (2) Tif-IA Lethal strong en-GAL4 20493818
Notch pathway regulation (2) Tif-IA Lethal strong en-GAL4 20493818
Notch pathway regulation (2) Tif-IA Downregulation of Notch pathway; adult wing margin: notches sp C96-GAL4 20493818
Notch pathway regulation (2) Tif-IA Downregulation of Notch pathway; adult wing margin: notches sp C96-GAL4 20493818
Notch pathway regulation (3) Tif-IA Upregulation of Notch pathway np   20493818
RTK-Ras-ERK pathway regulation (1) Tif-IA none -0.35 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Tif-IA Increased ERK phosphorylation after EGF stimulation 5.76 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Tif-IA none -0.59 30 minutes sSpitz stimulation 22028469

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