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Gene : hyx D. melanogaster

DB identifier  ? FBgn0037657 Secondary Identifier  ? CG11990
Name  ? hyrax Source  FlyBase
  • synonyms:
  • FBan0011990,
  • hyx/CDC73,
  • Cdc73,
  • CG11990,
  • Hyrax,
  • Hyx,
  • FBgn0037657,
  • Parafibromin

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14 Alleles

DB identifier Symbol Allele Class Organism
FBal0281845 hyx[WT.alphaTub84B.T:Ivir\HA1]   Drosophila melanogaster
FBal0281846 hyx[A2P.alphaTub84B.T:Ivir\HA1]   Drosophila melanogaster
FBal0245331 hyx[HM04031]   Drosophila melanogaster
FBal0162506 hyx[EY06898] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0262604 hyx[GL00123]   Drosophila melanogaster
FBal0193880 hyx[EP9]   Drosophila melanogaster
FBal0193881 hyx[EP10]   Drosophila melanogaster
FBal0193884 hyx[2]   Drosophila melanogaster
FBal0193882 hyx[Scer\UAS.cMa]   Drosophila melanogaster
FBal0193883 hyx[1]   Drosophila melanogaster
FBal0209713 hyx[GD12640]   Drosophila melanogaster
FBal0271060 hyx[NIG.11990R]   Drosophila melanogaster
FBal0222112 hyx[NP0125]   Drosophila melanogaster
FBal0231054 hyx[KK101075]   Drosophila melanogaster

40 Clones

Secondary Identifier DB identifier
EK206457 FBcl0029142
EK188751 FBcl0029160
EK177741 FBcl0029850
EK198612 FBcl0034236
EK304131 FBcl0034380
EK142133 FBcl0034524
EK027958 FBcl0034660
EK252519 FBcl0034756
EK122421 FBcl0033124
CK00528 FBcl0060605
GM22517 FBcl0148365
LD02894 FBcl0153651
LD04570 FBcl0153653
LD21646 FBcl0166616
LD31379 FBcl0166632
LD37015 FBcl0166639
LD36807 FBcl0166647
LD31292 FBcl0166653
LD47989 FBcl0166657
LD42563 FBcl0166663
LD42413 FBcl0166670
LD47747 FBcl0166671
RE26076 FBcl0202780
RE32957 FBcl0202782
RE60982 FBcl0202854
RH58945 FBcl0248186
RH69943 FBcl0248187
65349 FBcl0394832
IP11916 FBcl0319721
Dmel_neb_015467_0682_2852 FBcl0368259

7 Exons

DB identifier Symbol
FBgn0037657:3 hyx:3
FBgn0037657:4 hyx:4
FBgn0037657:5 hyx:5
FBgn0037657:6 hyx:6
FBgn0037657:7 hyx:7
FBgn0037657:1 hyx:1
FBgn0037657:2 hyx:2

2 Transcripts

DB identifier Gene
FBtr0081968 hyx
FBtr0300415 hyx

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0081968-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0300415-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0081968-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0300415-3-prime-utr Drosophila melanogaster

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0 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
41086 NCBI Entrez Gene identifiers FBgn0037657
66254 BioGRID FBgn0037657

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 784.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 838.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 719.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 779.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 773.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 623.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 864.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1086.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 477.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 807.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 867.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 430.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 772.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 573.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 739.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 795.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 763.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 849.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 663.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 571.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 726.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 880.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 596.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 599.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 802.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1933.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2000.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1983.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1236.0
FBgn0037657 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1153.0

6 Introns

DB identifier
Organism . Name
intron_FBgn0037657:3_FBgn0037657:4 Drosophila melanogaster
intron_FBgn0037657:4_FBgn0037657:5 Drosophila melanogaster
intron_FBgn0037657:5_FBgn0037657:6 Drosophila melanogaster
intron_FBgn0037657:6_FBgn0037657:7 Drosophila melanogaster
intron_FBgn0037657:1_FBgn0037657:2 Drosophila melanogaster
intron_FBgn0037657:2_FBgn0037657:4 Drosophila melanogaster

34 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage hyx none 0.014731857   19067489
Lipid storage hyx none -1.129827151   19067489
ERK signaling hyx ERK activation increased strong   17086199
Imd pathway regulation hyx Decreased Dipt::lacZ protein expression after lipopolysaccharide stimulation 4   15221030
Intracellular Listeria monocytogenes infection hyx Decreased GFP protein expression moderate   16020693
Mycobacterial infection (1) - M. fortuitum infection hyx Decreased M. fortuitum intracellular infection 5 measurement after 3 days 16020694
Mycobacterial infection (2) - E. coli phagocytosis hyx Decreased E. coli phagocytosis np   16020694
Constitutive protein secretion and Golgi organization (1) hyx Decreased horseradish peroxidase protein expression sp   16452979
Constitutive protein secretion and Golgi organization (2) hyx Fragmented Golgi membranes np   16452979
Cell size and cell-cycle regulation (1) hyx none sp   16496002
Muscle morphogenesis and function (1) hyx Lethal np   20220848
Muscle morphogenesis and function (1) hyx Lethal np   20220848
Muscle morphogenesis and function (2) hyx Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Muscle morphogenesis and function (3) hyx Fading Z-line np   20220848
Heat nociception (1) hyx Developmentally lethal 0   21074052
Heart development and function (1) hyx Pupal lethal 0.33   20371351
Serratia marcescens infection (1) hyx none 1.32835820895522   19520911
Notch pathway regulation (4) hyx Completely lethal (before pupal) sp   19363474
Notch pathway regulation (4) hyx Completely lethal (before pupal) sp   19363474
Adiposity regulation (1) hyx none -0.056   20074523
Blood cell homeostasis regulation (1) hyx Increased melanotic mass formation np   20540764
Blood cell homeostasis regulation (2) hyx none np   20540764
Blood cell homeostasis regulation (3) hyx Increased melanotic mass formation 55   20540764
Blood cell homeostasis regulation (4) hyx Increased melanotic mass formation 8.3   20540764
Blood cell homeostasis regulation (5) hyx Increased melanotic mass formation 7.7   20540764
Blood cell homeostasis regulation (6) hyx Increased melanotic mass formation 63.8   20540764
Blood cell homeostasis regulation (7) hyx Increased melanotic mass formation 18.8   20540764
Blood cell homeostasis regulation (8) hyx Increased melanotic mass formation 39.1   20540764
RTK-Ras-ERK pathway regulation (1) hyx Increased ERK phosphorylation after EGF stimulation 2.48 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) hyx none 0.62 10 minutes EGF stimulation 22028469

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