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Gene : Rpd3 D. melanogaster

DB identifier  ? FBgn0015805 Secondary Identifier  ? CG7471
Name  ? Rpd3 Source  FlyBase
  • synonyms:
  • DHDAC1,
  • Su(var)328,
  • E(var)3-64BC,
  • Rpd3 histone deacetylase,
  • Suppressor of variegation 326,
  • Rpd3/HDAC,
  • FBgn0015805,
  • HDAC,
  • FBgn0003632,
  • dmHDA401,
  • reduced potassium dependency 3,
  • Histone Deacetylase 1,
  • FBgn0003634,
  • DmHDAC1,
  • FBgn0016893,
  • Histone Deacetylase-1,
  • HDAC-1,
  • Su(var)326,
  • histone deacetylase,
  • FBan0007471,
  • CG7471,
  • FBgn0010843,
  • rpd[3],
  • HDAC1,
  • l(3)64Cc,
  • dHDAC-1,
  • DRpd3,
  • Su(var)3-26,
  • RPD3,
  • l(3)04556,
  • Histone Deacetylase 1 (HDAC1)

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38 Alleles

DB identifier Symbol Allele Class Organism
FBal0211948 Rpd3[CB04302]   Drosophila melanogaster
FBal0266332 Rpd3[GL01005]   Drosophila melanogaster
FBal0257292 Rpd3[HMS00607]   Drosophila melanogaster
FBal0245672 Rpd3[JF01401]   Drosophila melanogaster
FBal0181778 Rpd3[e01851]   Drosophila melanogaster
FBal0181779 Rpd3[c04194]   Drosophila melanogaster
FBal0009513 Rpd3[04556] loss of function allele, hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0119424 Rpd3[EP3672]   Drosophila melanogaster
FBal0045042 Rpd3[15-1] loss of function allele Drosophila melanogaster
FBal0243976 Rpd3[dsRNA.Scer\UAS.R15]   Drosophila melanogaster
FBal0104003 Rpd3[303] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0051881 Rpd3[326] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0049829 Rpd3[4-4]   Drosophila melanogaster
FBal0101561 Rpd3[H196F.Act5C]   Drosophila melanogaster
FBal0104001 Rpd3[328] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0103999 Rpd3[def8] loss of function allele Drosophila melanogaster
FBal0152243 Rpd3[X5]   Drosophila melanogaster
FBal0049827 Rpd3[1-3]   Drosophila melanogaster
FBal0049830 Rpd3[5-2]   Drosophila melanogaster
FBal0049831 Rpd3[5-5]   Drosophila melanogaster
FBal0104000 Rpd3[def24] loss of function allele Drosophila melanogaster
FBal0104002 Rpd3[313] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0049828 Rpd3[3-10]   Drosophila melanogaster
FBal0155940 Rpd3[unspecified]   Drosophila melanogaster
FBal0263160 Rpd3[HMS00164]   Drosophila melanogaster
FBal0144615 Rpd3[Act5C.T:SV5\V5,T:Zzzz\His6]   Drosophila melanogaster
FBal0101560 Rpd3[H196F.Act5C.T:Scer\GAL4]   Drosophila melanogaster
FBal0155941 Rpd3[hs.T:Scer\GAL4]   Drosophila melanogaster
FBal0101559 Rpd3[WT.Act5C.T:Scer\GAL4]   Drosophila melanogaster
FBal0101558 Rpd3[WT.Act5C.T:Zzzz\FLAG]   Drosophila melanogaster

185 Clones

Secondary Identifier DB identifier
DPiM_GM14158 FBcl0741415
DMG4-chr3L.9.004.pred.a FBcl0384135
ESG012b.E21.3_E10 FBcl0012733
EK054158 FBcl0076694
EK131326 FBcl0076706
EK227146 FBcl0076934
EK145253 FBcl0076992
EK269123 FBcl0077046
GH06224 FBcl0108117
GH12844 FBcl0109037
GM08668 FBcl0140125
GM14158 FBcl0145336
GM29592 FBcl0145339
LD20785 FBcl0152527
LD07940 FBcl0152534
LD18520 FBcl0152574
LD04593 FBcl0152585
LD01433 FBcl0152587
LD19588 FBcl0152601
LD11807 FBcl0152603
LD02133 FBcl0152606
LD04484 FBcl0152611
LD08522 FBcl0152627
LD17138 FBcl0152628
LD15455 FBcl0152685
LD02546 FBcl0152691
LD02817 FBcl0152692
LD06478 FBcl0152698
LD07541 FBcl0152707
LD04115 FBcl0152709

4 Exons

DB identifier Symbol
FBgn0015805:1 Rpd3:1
FBgn0015805:2 Rpd3:2
FBgn0015805:3 Rpd3:3
FBgn0015805:4 Rpd3:4

1 Transcripts

DB identifier Gene
FBtr0073317 Rpd3

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0073317-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0073317-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
38565 NCBI Entrez Gene identifiers FBgn0015805
64037 BioGRID FBgn0015805

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1606.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1997.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 1579.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1939.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1967.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 2563.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1481.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1443.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1606.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1486.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1973.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1323.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 2533.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 2075.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 3156.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 2281.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 2304.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 2317.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 3099.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 2493.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1878.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 2154.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1616.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1454.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 1189.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 7045.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 7832.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 7940.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 5008.0
FBgn0015805 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 4558.0

3 Introns

DB identifier
Organism . Name
intron_FBgn0015805:1_FBgn0015805:2 Drosophila melanogaster
intron_FBgn0015805:2_FBgn0015805:3 Drosophila melanogaster
intron_FBgn0015805:3_FBgn0015805:4 Drosophila melanogaster

36 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Rpd3 none -2.040276705   19067489
Lipid storage Rpd3 none -1.085464268   19067489
Cell size and cell-cycle regulation (1) Rpd3 none sp   16496002
Dendrite pattern formation Rpd3 Increased arborization np   16547170
Mitochondrial biogenesis and function Rpd3 Increased mitochondrial citrate synthase activity 1.497   18042644
Combinatorial effect with methyl methanesulphonate (2) Rpd3 none sp   19543366
Muscle morphogenesis and function (1) Rpd3 Flightless np   20220848
Muscle morphogenesis and function (1) Rpd3 Lethal np   20220848
Muscle morphogenesis and function (1) Rpd3 Lethal np   20220848
Muscle morphogenesis and function (4) Rpd3 none np   20220848
Heat nociception (1) Rpd3 none -1.17   21074052
Heat nociception (1) Rpd3 none -0.49   21074052
Heart development and function (1) Rpd3 none 1   20371351
Serratia marcescens infection (1) Rpd3 none -0.07   19520911
Serratia marcescens infection (1) Rpd3 none 1.43877551020408   19520911
Serratia marcescens infection (1) Rpd3 none 0.77   19520911
Serratia marcescens infection (1) Rpd3 none 0   19520911
Notch pathway regulation (4) Rpd3 Loss of bristles, notum malformation migration sp   19363474
Notch pathway regulation (4) Rpd3 Notum malformation death 8   19363474
Notch induced transcription Rpd3 none 1.1869 without Notch stimulation 20959007
Notch induced transcription Rpd3 Upregulation of Notch pathway after Notch stimulation 2.0025 N(delta)ecn Notch stimulation 20959007
Notch induced transcription Rpd3 none 0.1906 N(delta)ecn Notch stimulation 20959007
Akt-TOR pathway negative feedback regulation Rpd3 Decreased dAkt phosphorylation after insulin stimulation -2.8 10 min insulin stimulation 20585550
Self-renewal and differentiation in neural stem cells Rpd3 Ganglion mother cell shorter lineages, neuroblast underproliferation, lethal sp   21549331
Pol II elongation Rpd3 none 132 20 min heat shock 19279664
Adiposity regulation (1) Rpd3 none -0.323   20074523
Adiposity regulation (1) Rpd3 none -0.259   20074523
Adiposity regulation (1) Rpd3 none -0.025   20074523
Adiposity regulation (1) Rpd3 none 0.016   20074523
RTK-Ras-ERK pathway regulation (1) Rpd3 none -0.33 10 minutes EGF stimulation 22028469

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