Genomics
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73 Alleles
207 Clones
8 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0011217:6 | eff:6 |
| FBgn0011217:5 | eff:5 |
| FBgn0011217:4 | eff:4 |
| FBgn0011217:3 | eff:3 |
| FBgn0011217:1 | eff:1 |
| FBgn0011217:8 | eff:8 |
| FBgn0011217:7 | eff:7 |
| FBgn0011217:2 | eff:2 |
6 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0083018-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0310554-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0336876-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0083018-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0310554-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0336876-3-prime-utr | Drosophila melanogaster |
Other
80 Pathways
- Cell Cycle,
- Mitotic Spindle Checkpoint,
- Signaling by Activin,
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription,
- Cellular response to hypoxia,
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,
- Generic Transcription Pathway,
- TGF-beta receptor signaling activates SMADs,
- Cell Cycle, Mitotic,
- Homologous recombination repair of replication-independent double-strand breaks,
- Gene Expression,
- Loss of Function of TGFBR2 in Cancer,
- ATM mediated response to DNA double-strand break,
- Amplification of signal from the kinetochores,
- Phosphorylation of the APC/C,
- p53-Independent G1/S DNA damage checkpoint,
- Signaling Pathways,
- G2/M DNA replication checkpoint,
- APC/C:Cdc20 mediated degradation of mitotic proteins,
- M Phase,
- Disease,
- Cyclin E associated events during G1/S transition,
- APC/C:Cdc20 mediated degradation of Securin,
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A,
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal,
- Loss of Function of SMAD4 in Cancer,
- Mitotic G1-G1/S phases,
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A,
- Regulation of mitotic cell cycle,
- Double-Strand Break Repair,
- Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha,
- G2/M Transition,
- Loss of Function of SMAD2/3 in Cancer,
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex,
- APC/C:Cdc20 mediated degradation of Cyclin B,
- Developmental Biology,
- TGFBR1 LBD Mutants in Cancer,
- APC/C-mediated degradation of cell cycle proteins,
- APC-Cdc20 mediated degradation of Nek2A,
- Cellular Senescence,
- Senescence-Associated Secretory Phenotype (SASP),
- G1/S Transition,
- Inactivation of APC/C via direct inhibition of the APC/C complex,
- SMAD2/3 Phosphorylation Motif Mutants in Cancer,
- TGFBR2 Kinase Domain Mutants in Cancer,
- Signaling by NODAL,
- G2/M DNA damage checkpoint,
- Cyclin A/B1 associated events during G2/M transition,
- Polo-like kinase mediated events,
- Separation of Sister Chromatids,
- SMAD2/3 MH2 Domain Mutants in Cancer,
- Cellular responses to stress,
- G1/S DNA Damage Checkpoints,
- Cyclin A:Cdk2-associated events at S phase entry,
- Regulation of Hypoxia-inducible Factor (HIF) by Oxygen,
- DNA Repair,
- DNA Replication,
- Loss of Function of TGFBR1 in Cancer,
- Mitotic G2-G2/M phases,
- TGFBR1 KD Mutants in Cancer,
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,
- TGFBR2 MSI Frameshift Mutants in Cancer,
- p53-Independent DNA Damage Response,
- Mitotic M-M/G1 phases,
- Mitotic Metaphase and Anaphase,
- Signaling by TGF-beta Receptor Complex in Cancer,
- Regulation of APC/C activators between G1/S and early anaphase,
- SCF(Skp2)-mediated degradation of p27/p21,
- Mitotic Anaphase,
- S Phase,
- Signaling by TGF-beta Receptor Complex,
- Downregulation of SMAD2/3:SMAD4 transcriptional activity,
- Cell Cycle Checkpoints,
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer,
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase,
- Homologous Recombination Repair,
- SMAD4 MH2 Domain Mutants in Cancer,
- Autodegradation of Cdh1 by Cdh1:APC/C,
- G2/M Checkpoints
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 41785 | NCBI Entrez Gene identifiers | FBgn0011217 |
| 66859 | BioGRID | FBgn0011217 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
7 Introns
30 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | eff | none | -0.339225293 | 19067489 | |
| Lipid storage | eff | none | 1.86430298 | 19067489 | |
| Imd pathway regulation | eff | Increased Dipt::lacZ protein expression after lipopolysaccharide stimulation | 24 | 15221030 | |
| Hedgehog signaling | eff | Decreased Hedgehog reporter activity | -2.79 | 16311596 | |
| Constitutive protein secretion and Golgi organization (1) | eff | Decreased horseradish peroxidase protein expression | sp | 16452979 | |
| Cell size and cell-cycle regulation (1) | eff | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | eff | none | sp | 16496002 | |
| Lipid storage | eff | Fewer lipid droplets | strong | 18408709 | |
| Muscle morphogenesis and function (1) | eff | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (1) | eff | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | eff | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Heat nociception (1) | eff | Developmentally lethal | 0 | 21074052 | |
| Heat nociception (1) | eff | Developmentally lethal | -1.17 | 21074052 | |
| Heart development and function (1) | eff | none | 1 | 20371351 | |
| Heart development and function (2) | eff | Decreased viability | 7.27 | 20371351 | |
| Serratia marcescens infection (1) | eff | none | 1.01408450704225 | 19520911 | |
| Notch pathway regulation (4) | eff | Completely lethal (pupal) | sp | 19363474 | |
| Notch pathway regulation (4) | eff | Completely lethal (pupal) | sp | 19363474 | |
| Akt-TOR pathway negative feedback regulation | eff | Decreased dAkt phosphorylation after insulin stimulation | -2.8 | 10 min insulin stimulation | 20585550 |
| Hh pathway regulation | eff | Downregulation of Hh pathway | -0.324781103941061 | 17903264 | |
| Hh pathway regulation | eff | Downregulation of Hh pathway | -0.261023598276345 | 17903264 | |
| Self-renewal and differentiation in neural stem cells | eff | GFP aggregates number, GFP aggregates size, ganglion mother cell shorter lineages, neuroblast underproliferation, lethal | sp | 21549331 | |
| Notch pathway regulation (1) | eff | Upregulation of Notch pathway | np | 20493818 | |
| Notch pathway regulation (2) | eff | Delay of larval development; lethal | sp | en-GAL4 | 20493818 |
| Notch pathway regulation (2) | eff | none | np | C96-GAL4 | 20493818 |
| Notch pathway regulation (2) | eff | none | np | en-GAL4 | 20493818 |
| Notch pathway regulation (3) | eff | Upregulation of Notch pathway | np | 20493818 | |
| Hippo pathway regulation | eff | none | -1.07 | 23263283 | |
| Srp/Lz-induced transcriptional activation | eff | Decreased Srp/Lz-induced transcription | -4.62 | 20368357 | |
| Glycosylation regulation (1) | eff | none | sp | 21203496 |
