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Gene : Ras85D D. melanogaster

DB identifier  ? FBgn0003205 Secondary Identifier  ? CG9375
Name  ? Ras oncogene at 85D Source  FlyBase
  • synonyms:
  • RAS,
  • l(3)06677,
  • RasI,
  • Ras GTPase,
  • Dm Ras1,
  • ras85B,
  • EK3-4,
  • DRas,
  • RTK,
  • RAS1,
  • Dmras85D,
  • E(faf),
  • fs(3)05703,
  • DRas85D/Ras,
  • FBgn0003205,
  • E(sev)3C,
  • RasV12,
  • FBgn0011548,
  • FBgn0011008,
  • Su(tor)3-2,
  • CG9375,
  • Enhancer of faf,
  • l(3)s1747,
  • FBan0009375,
  • C-ras1,
  • D-ras-1,
  • D-Ras,
  • P08646,
  • p21[Ras1],
  • Ras 85D,
  • ras 1,
  • D-Ras1,
  • Dras85D,
  • Ras oncogene at 85B,
  • Ras185D,
  • RAS85D,
  • DRAS1,
  • S35097,
  • Ras-1,
  • Ras[V12],
  • Ras1/RAs85D

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129 Alleles

DB identifier Symbol Allele Class Organism
FBal0196150 Ras85D[MAE-2]   Drosophila melanogaster
FBal0196151 Ras85D[MDE-7]   Drosophila melanogaster
FBal0182005 Ras85D[d07821]   Drosophila melanogaster
FBal0182007 Ras85D[d03849]   Drosophila melanogaster
FBal0182006 Ras85D[d06412]   Drosophila melanogaster
FBal0182008 Ras85D[d01830]   Drosophila melanogaster
FBal0276789 Ras85D[V12.cUa.Scer\UAS]   Drosophila melanogaster
FBal0042723 Ras85D[05703] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0248865 Ras85D[VDRC.cUa]   Drosophila melanogaster
FBal0182009 Ras85D[c03294]   Drosophila melanogaster
FBal0033977 Ras85D[A140]   Drosophila melanogaster
FBal0159930 Ras85D[EY07538]   Drosophila melanogaster
FBal0058374 Ras85D[ix13b]   Drosophila melanogaster
FBal0058375 Ras85D[ix12a] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0159931 Ras85D[A014]   Drosophila melanogaster
FBal0009572 Ras85D[06677]   Drosophila melanogaster
FBal0130799 Ras85D[EP3262]   Drosophila melanogaster
FBal0011134 Ras85D[s1747]   Drosophila melanogaster
FBal0257889 Ras85D[HMS01294]   Drosophila melanogaster
FBal0257034 Ras85D[NIG.9375R]   Drosophila melanogaster
FBal0147574 Ras85D[EY00505]   Drosophila melanogaster
FBal0242163 Ras85D[JF02478]   Drosophila melanogaster
FBal0248796 Ras85D[K187V.Scer\UAS.T:Hsap\MYC]   Drosophila melanogaster
FBal0248797 Ras85D[Ktail6Q.Scer\UAS.T:Hsap\MYC.T:Hsap\CAAX-6Q]   Drosophila melanogaster
FBal0248798 Ras85D[Ktail.Scer\UAS.T:Hsap\CAAX.T:Hsap\MYC]   Drosophila melanogaster
FBal0248799 Ras85D[C186S.Scer\UAS.T:Hsap\MYC]   Drosophila melanogaster
FBal0248800 Ras85D[12V,C186S.Scer\UAS.T:Hsap\MYC]   Drosophila melanogaster
FBal0285348 Ras85D[R68Q]   Drosophila melanogaster
FBal0285349 Ras85D[R11]   Drosophila melanogaster
FBal0285350 Ras85D[R41]   Drosophila melanogaster

29 Clones

Secondary Identifier DB identifier
DPiM_LD17536 FBcl0741390
EK165218 FBcl0001666
EK180916 FBcl0002622
EK168547 FBcl0005526
EK160922 FBcl0005546
EK140514 FBcl0005568
EK174030 FBcl0040544
EK040924 FBcl0044774
EK229662 FBcl0044840
CK01231 FBcl0058807
EC31663 FBcl0060871
EN03612 FBcl0090541
LD06783 FBcl0151079
LD03217 FBcl0151102
LD17333 FBcl0151136
LD18026 FBcl0151186
LD17536 FBcl0151189
RE71939 FBcl0192112
RE59256 FBcl0192160
RE48011 FBcl0192175
RE53955 FBcl0192446
RE05330 FBcl0194385
RE37948 FBcl0197100
RE71338 FBcl0197322
RE04376 FBcl0197732
SD04757 FBcl0275435
SD04756 FBcl0275436
FGC016F05 FBcl0385353
FGM207B12 FBcl0389561

4 Exons

DB identifier Symbol
FBgn0003205:4 Ras85D:4
FBgn0003205:3 Ras85D:3
FBgn0003205:2 Ras85D:2
FBgn0003205:1 Ras85D:1

1 Transcripts

DB identifier Gene
FBtr0082122 Ras85D

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0082122-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0082122-3-prime-utr Drosophila melanogaster

Interactions

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61 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
41140 NCBI Entrez Gene identifiers FBgn0003205
66301 BioGRID FBgn0003205

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1918.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1708.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 884.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1410.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1316.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1329.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1930.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 2371.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1419.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1519.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1638.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1214.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1157.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1402.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1474.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 991.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1138.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 989.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1584.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1606.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 2362.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1499.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1201.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1833.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 932.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 3168.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 3236.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 2203.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1712.0
FBgn0003205 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1561.0

3 Introns

DB identifier
Organism . Name
intron_FBgn0003205:4_FBgn0003205:3 Drosophila melanogaster
intron_FBgn0003205:3_FBgn0003205:2 Drosophila melanogaster
intron_FBgn0003205:2_FBgn0003205:1 Drosophila melanogaster

24 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Cell size regulation Ras85D Decreased cell size -2.3   19216764
Lipid storage Ras85D none -0.17198035   19067489
Lipid storage Ras85D none 0.332840434   19067489
ERK signaling Ras85D ERK activation reduced strong   17086199
Cell morphology Ras85D Morphology np   14527345
Imd pathway regulation Ras85D Increased Dipt::lacZ protein expression after lipopolysaccharide stimulation 22   15221030
Mycobacterial infection (1) - M. fortuitum infection Ras85D Decreased M. fortuitum intracellular infection 4.3 measurement after 3 days 16020694
Constitutive protein secretion and Golgi organization (1) Ras85D Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Ras85D none sp   16496002
Cell size and cell-cycle regulation (1) Ras85D none sp   16496002
Muscle morphogenesis and function (1) Ras85D none np   20220848
Heat nociception (1) Ras85D none -0.14   21074052
Heart development and function (1) Ras85D none 1   20371351
Serratia marcescens infection (1) Ras85D none -0.714285714285714   19520911
Notch pathway regulation (4) Ras85D Completely lethal (pupal) sp   19363474
PGN-induced dJNK phosphorylation Ras85D Increased P-JNK protein expression with PGN 3.44 15 min PGN induction 19893628
Adiposity regulation (1) Ras85D none -0.509   20074523
RTK-Ras-ERK pathway regulation (1) Ras85D Decreased ERK phosphorylation after EGF stimulation -5.71 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Ras85D Decreased ERK phosphorylation after EGF stimulation -2.96 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Ras85D Decreased ERK phosphorylation after sSpitz and EGF stimulation -3.47 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Ras85D Decreased ERK phosphorylation after sSpitz and EGF stimulation -4.51 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation Ras85D Downregulation of Hippo pathway 3.85   23263283
Immune deficiency pathway regulation Ras85D Upregulation of IMD pathway after E.coli stimulation 4.76   21297578
Glycosylation regulation (1) Ras85D none sp   21203496

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