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Gene : Fs(2)Ket D. melanogaster

DB identifier  ? FBgn0262743 Secondary Identifier  ? CG2637
Name  ? Female sterile (2) Ketel Source  FlyBase
  • synonyms:
  • female sterile(2)lto2,
  • FBgn0005392,
  • Kpnb1,
  • Ket,
  • imp-beta,
  • Hon,
  • MRE26,
  • Hont,
  • Ketel,
  • FBan0002637,
  • fs(2)Ket,
  • fs(2)lo-B,
  • 38E.11,
  • importin beta1,
  • Fs(2)Sz6,
  • FBgn0000986,
  • FBgn0086557,
  • Impbeta,
  • Fs(2)Sz7,
  • FBgn0000989,
  • FBgn0262743,
  • Importin beta,
  • kettle,
  • fs(2) Ketel,
  • CG2637,
  • FBgn0004812,
  • IMPbeta1,
  • fs(2)ltoHD43,
  • fs(2)lto2,
  • FBgn0000984,
  • DImportin-beta,
  • Importin-beta,
  • mRNA-like ncRNA in embryogenesis 26,
  • dKap-beta,
  • Fs(2)Hon

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56 Alleles

DB identifier Symbol Allele Class Organism
FBal0211686 Fs(2)Ket[CA07301]   Drosophila melanogaster
FBal0183521 Fs(2)Ket[e02150]   Drosophila melanogaster
FBal0245940 Fs(2)Ket[JF01755]   Drosophila melanogaster
FBal0183519 Fs(2)Ket[e03750]   Drosophila melanogaster
FBal0183520 Fs(2)Ket[e02657]   Drosophila melanogaster
FBal0183522 Fs(2)Ket[c02473]   Drosophila melanogaster
FBal0135982 Fs(2)Ket[EP2088]   Drosophila melanogaster
FBal0156450 Fs(2)Ket[EY06666]   Drosophila melanogaster
FBal0089698 Fs(2)Ket[RP13]   Drosophila melanogaster
FBal0089699 Fs(2)Ket[RP12]   Drosophila melanogaster
FBal0089700 Fs(2)Ket[RP11]   Drosophila melanogaster
FBal0244384 Fs(2)Ket[Scer\UAS.cVa]   Drosophila melanogaster
FBal0278727 Fs(2)Ket[GL01273]   Drosophila melanogaster
FBal0089692 Fs(2)Ket[RX14]   Drosophila melanogaster
FBal0089704 Fs(2)Ket[RE31]   Drosophila melanogaster
FBal0120817 Fs(2)Ket[III]   Drosophila melanogaster
FBal0120818 Fs(2)Ket[+t22]   Drosophila melanogaster
FBal0120819 Fs(2)Ket[+t13.8]   Drosophila melanogaster
FBal0048751 Fs(2)Ket[2] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0183523 Fs(2)Ket[S317T.P446L]   Drosophila melanogaster
FBal0183524 Fs(2)Ket[P446L] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0089685 Fs(2)Ket[RX2]   Drosophila melanogaster
FBal0089688 Fs(2)Ket[RX18]   Drosophila melanogaster
FBal0004615 Fs(2)Ket[4] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0004617 Fs(2)Ket[1] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0089691 Fs(2)Ket[RX15]   Drosophila melanogaster
FBal0089693 Fs(2)Ket[RX13]   Drosophila melanogaster
FBal0089687 Fs(2)Ket[RX19]   Drosophila melanogaster
FBal0089697 Fs(2)Ket[RS1]   Drosophila melanogaster
FBal0089703 Fs(2)Ket[RE32]   Drosophila melanogaster

67 Clones

Secondary Identifier DB identifier
EC14703 FBcl0065245
EP17924 FBcl0079293
EK181802 FBcl0079360
EK294901 FBcl0079378
EK060758 FBcl0082960
EK149304 FBcl0083048
EK149526 FBcl0083080
EK200340 FBcl0083112
EK127838 FBcl0084184
EK187136 FBcl0084310
EK297207 FBcl0084466
EK224305 FBcl0084514
EK185325 FBcl0084672
EK208733 FBcl0084688
EK309234 FBcl0084704
EK295840 FBcl0084738
EK272603 FBcl0084786
EK276148 FBcl0084812
EN07351 FBcl0094291
GH05801 FBcl0112931
GH24850 FBcl0113179
GM13294 FBcl0145415
GM32503 FBcl0145438
GM32540 FBcl0145439
HL02837 FBcl0149284
HL08176 FBcl0150872
LD26911 FBcl0168083
LD46945 FBcl0168085
LD27264 FBcl0168086
RE21558 FBcl0206989

14 Exons

DB identifier Symbol
FBgn0262743:2 Fs(2)Ket:2
FBgn0262743:4 Fs(2)Ket:4
FBgn0262743:5 Fs(2)Ket:5
FBgn0262743:6 Fs(2)Ket:6
FBgn0262743:7 Fs(2)Ket:7
FBgn0262743:8 Fs(2)Ket:8
FBgn0262743:11 Fs(2)Ket:11
FBgn0262743:12 Fs(2)Ket:12
FBgn0262743:14 Fs(2)Ket:14
FBgn0262743:9 Fs(2)Ket:9
FBgn0262743:1 Fs(2)Ket:1
FBgn0262743:3 Fs(2)Ket:3
FBgn0262743:10 Fs(2)Ket:10
FBgn0262743:13 Fs(2)Ket:13

5 Transcripts

DB identifier Gene
FBtr0305586 Fs(2)Ket
FBtr0305585 Fs(2)Ket
FBtr0081392 Fs(2)Ket
FBtr0305587 Fs(2)Ket
FBtr0305584 Fs(2)Ket

10 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0305586-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0081392-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0305584-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0305585-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0305587-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0305586-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0081392-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0305584-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0305585-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0305587-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
35336 NCBI Entrez Gene identifiers FBgn0262743
61299 BioGRID FBgn0262743

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  

0 Expression Scores

14 Introns

DB identifier
Organism . Name
intron_FBgn0262743:2_FBgn0262743:4 Drosophila melanogaster
intron_FBgn0262743:4_FBgn0262743:5 Drosophila melanogaster
intron_FBgn0262743:5_FBgn0262743:6 Drosophila melanogaster
intron_FBgn0262743:6_FBgn0262743:7 Drosophila melanogaster
intron_FBgn0262743:7_FBgn0262743:8 Drosophila melanogaster
intron_FBgn0262743:8_FBgn0262743:11 Drosophila melanogaster
intron_FBgn0262743:11_FBgn0262743:12 Drosophila melanogaster
intron_FBgn0262743:12_FBgn0262743:14 Drosophila melanogaster
intron_FBgn0262743:8_FBgn0262743:10 Drosophila melanogaster
intron_FBgn0262743:10_FBgn0262743:13 Drosophila melanogaster
intron_FBgn0262743:1_FBgn0262743:3 Drosophila melanogaster
intron_FBgn0262743:3_FBgn0262743:4 Drosophila melanogaster
intron_FBgn0262743:8_FBgn0262743:9 Drosophila melanogaster
intron_FBgn0262743:8_FBgn0262743:13 Drosophila melanogaster

26 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Fs(2)Ket Increased lipid droplet area 7.315797566   19067489
Lipid storage Fs(2)Ket Increased lipid droplet area 11.43772885   19067489
Ca2+ signaling Fs(2)Ket Decreased NFAT translocation strong   17293345
ERK signaling Fs(2)Ket ERK activation reduced strong   17086199
Cell morphology Fs(2)Ket Morphology np   14527345
Wnt signaling Fs(2)Ket Increased Wnt reporter activity 19.61   15817814
Constitutive protein secretion and Golgi organization (1) Fs(2)Ket Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Fs(2)Ket none sp   16496002
Microtubule assembly and organization Fs(2)Ket Abnormal spindle, chromosome alignment defect, central spindle defect np   18463163
Mutant human huntingtin aggregation Fs(2)Ket Decreased mutant human huntingtin aggregation <= -2   19789644
Muscle morphogenesis and function (1) Fs(2)Ket Lethal np   20220848
Heat nociception (1) Fs(2)Ket Developmentally lethal 1.41   21074052
Heart development and function (1) Fs(2)Ket none 1   20371351
Serratia marcescens infection (1) Fs(2)Ket none 0.883116883116883   19520911
Notch pathway regulation (4) Fs(2)Ket Completely lethal (pupal) sp   19363474
PGN-induced dJNK phosphorylation Fs(2)Ket Increased P-JNK protein expression with PGN 2.62 60 min PGN induction 19893628
Adiposity regulation (1) Fs(2)Ket none -0.355   20074523
RTK-Ras-ERK pathway regulation (1) Fs(2)Ket none -0.07 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Fs(2)Ket Decreased ERK phosphorylation after EGF stimulation -2.97 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Fs(2)Ket none -0.67 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Fs(2)Ket none 0.39 30 minutes sSpitz stimulation 22028469
Wnt proteins secretion Fs(2)Ket none 0.6   22094269
Hippo pathway regulation Fs(2)Ket none 0.03   23263283
Srp/Lz-induced transcriptional activation Fs(2)Ket Increased Srp/Lz-induced transcription 13.11   20368357
Glycosylation regulation (1) Fs(2)Ket Increased alpha1,3-fucose Chp glycosylation, decreased (GlcNAc)n Chp glycosylation sp   21203496
Glycosylation regulation (2) Fs(2)Ket none np   21203496

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