Genomics
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12 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0258431 | Roc1a[grf.T:SV5\V5] | Drosophila melanogaster | |
| FBal0248118 | Roc1a[HMS00353] | Drosophila melanogaster | |
| FBal0147541 | Roc1a[N59R.C68R] | Drosophila melanogaster | |
| FBal0147543 | Roc1a[+tNa] | Drosophila melanogaster | |
| FBal0181848 | Roc1a[grf.Roc1b] | Drosophila melanogaster | |
| FBal0147542 | Roc1a[Hsp70.PN] | Drosophila melanogaster | |
| FBal0181847 | Roc1a[grf.T:Zzzz\FLAG] | Drosophila melanogaster | |
| FBal0181849 | Roc1a[Scer\UAS.cDa] | Drosophila melanogaster | |
| FBal0220042 | Roc1a[G824] | Drosophila melanogaster | |
| FBal0287316 | Roc1a[Scer\UAS.ORF] | Drosophila melanogaster | |
| FBal0208314 | Roc1a[GD8596] | Drosophila melanogaster | |
| FBal0235897 | Roc1a[KK108885] | Drosophila melanogaster |
42 Clones
5 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0025638:2 | Roc1a:2 |
| FBgn0025638:5 | Roc1a:5 |
| FBgn0025638:1 | Roc1a:1 |
| FBgn0025638:3 | Roc1a:3 |
| FBgn0025638:4 | Roc1a:4 |
6 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0308651-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0070122-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0343564-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0308651-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0070122-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0343564-3-prime-utr | Drosophila melanogaster |
Other
45 Pathways
- FBXW7 Mutants and NOTCH1 in Cancer,
- Toll Like Receptor TLR6:TLR2 Cascade,
- Signaling by NOTCH1 in Cancer,
- Interleukin-1 signaling,
- Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling,
- MyD88-independent cascade,
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant,
- Cellular responses to stress,
- NOD1/2 Signaling Pathway,
- IRAK2 mediated activation of TAK1 complex,
- NOTCH1 Intracellular Domain Regulates Transcription,
- MyD88 cascade initiated on plasma membrane,
- Toll Like Receptor 9 (TLR9) Cascade,
- Signaling by NOTCH1 HD Domain Mutants in Cancer,
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex,
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation,
- Signaling by NOTCH1 PEST Domain Mutants in Cancer,
- Signaling Pathways,
- Constitutive Signaling by NOTCH1 PEST Domain Mutants,
- Innate Immune System,
- Signaling by Interleukins,
- TRAF6 Mediated Induction of proinflammatory cytokines,
- Toll Like Receptor TLR1:TLR2 Cascade,
- Toll Like Receptor 5 (TLR5) Cascade,
- Toll-Like Receptors Cascades,
- Cytokine Signaling in Immune system,
- Activated TLR4 signalling,
- Toll Like Receptor 4 (TLR4) Cascade,
- Immune System,
- Disease,
- TRIF-mediated TLR3/TLR4 signaling,
- MyD88 dependent cascade initiated on endosome,
- Regulation of Hypoxia-inducible Factor (HIF) by Oxygen,
- Cellular response to hypoxia,
- Toll Like Receptor 10 (TLR10) Cascade,
- Toll Like Receptor 3 (TLR3) Cascade,
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants,
- Toll Like Receptor 7/8 (TLR7/8) Cascade,
- MyD88:Mal cascade initiated on plasma membrane,
- Toll Like Receptor 2 (TLR2) Cascade,
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer,
- Signaling by NOTCH1,
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways,
- Signaling by NOTCH,
- Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 31014 | NCBI Entrez Gene identifiers | FBgn0025638 |
| 57582 | BioGRID | FBgn0025638 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
23 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | Roc1a | Decreased lipid droplet area | -3.668187739 | 19067489 | |
| Lipid storage | Roc1a | Decreased lipid droplet area | -5.479845444 | 19067489 | |
| Constitutive protein secretion and Golgi organization (1) | Roc1a | Decreased horseradish peroxidase protein expression | sp | 16452979 | |
| Cell size and cell-cycle regulation (1) | Roc1a | Increased G1 DNA content, decreased G2 DNA content, increased G1 cell size, increased G2 cell size | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | Roc1a | none | 1.043 | 16496002 | |
| Cell size and cell-cycle regulation (3) | Roc1a | Decreased cell number | 371 | 16496002 | |
| Cell size and cell-cycle regulation (4) | Roc1a | none | below threshold | 16496002 | |
| Muscle morphogenesis and function (1) | Roc1a | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (1) | Roc1a | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | Roc1a | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Heat nociception (1) | Roc1a | none | -1.17 | 21074052 | |
| Heat nociception (1) | Roc1a | Developmentally lethal | -1.17 | 21074052 | |
| Heart development and function (1) | Roc1a | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | Roc1a | none | 0.453703703703703 | 19520911 | |
| Notch pathway regulation (4) | Roc1a | Completely lethal (before pupal) | sp | 19363474 | |
| Notch pathway regulation (4) | Roc1a | Completely lethal (before pupal) | sp | 19363474 | |
| Self-renewal and differentiation in neural stem cells | Roc1a | GFP aggregates number, GFP aggregates size, neuroblast less large cells, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with unchanged neuroblast cell size, neuroblast underproliferation, lethal | sp | 21549331 | |
| Adiposity regulation (1) | Roc1a | none | -0.152 | 20074523 | |
| RTK-Ras-ERK pathway regulation (1) | Roc1a | none | 0.53 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | Roc1a | none | -1.22 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | Roc1a | Increased ERK phosphorylation after sSpitz and EGF stimulation | 2.36 | 30 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | Roc1a | Increased ERK phosphorylation after sSpitz and EGF stimulation | 2.77 | 10 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | Roc1a | none | -0.12 | 23263283 |
