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Gene : eIF-2beta D. melanogaster

DB identifier  ? FBgn0004926 Secondary Identifier  ? CG4153
Name  ? Eukaryotic initiation factor 2beta Source  FlyBase
  • synonyms:
  • IF2B,
  • eIF-2,
  • FBgn0004926,
  • CG4153,
  • FBan0004153,
  • eIF-2beta,
  • elF2beta,
  • FBgn0024970,
  • Eif2beta,
  • D-eIF2beta

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13 Alleles

DB identifier Symbol Allele Class Organism
FBal0270125 eIF-2beta[NIG.4153R]   Drosophila melanogaster
FBal0211770 eIF-2beta[CC06208]   Drosophila melanogaster
FBal0180065 eIF-2beta[c05909]   Drosophila melanogaster
FBal0159291 eIF-2beta[EY08063]   Drosophila melanogaster
FBal0130401 eIF-2beta[EP745]   Drosophila melanogaster
FBal0212927 eIF-2beta[GE06433]   Drosophila melanogaster
FBal0212928 eIF-2beta[GE06414]   Drosophila melanogaster
FBal0212929 eIF-2beta[1]   Drosophila melanogaster
FBal0212930 eIF-2beta[2]   Drosophila melanogaster
FBal0212937 eIF-2beta[Scer\UAS.T:Avic\GFP]   Drosophila melanogaster
FBal0209461 eIF-2beta[GD1431]   Drosophila melanogaster
FBal0209462 eIF-2beta[GD16736]   Drosophila melanogaster
FBal0235822 eIF-2beta[KK108791]   Drosophila melanogaster

121 Clones

Secondary Identifier DB identifier
bs41b07 FBcl0055815
bs54a01 FBcl0055819
bs32g12 FBcl0055821
EC32126 FBcl0070769
EK242258 FBcl0094428
EK240058 FBcl0094496
EK296016 FBcl0094580
EK188517 FBcl0094774
EK264330 FBcl0094900
EK253436 FBcl0094914
GH11429 FBcl0136595
GH25491 FBcl0136603
GH12211 FBcl0136611
GH04004 FBcl0136613
GH21624 FBcl0136615
GH02354 FBcl0136617
GH07913 FBcl0136619
GM01015 FBcl0142991
GM12188 FBcl0147661
GM28248 FBcl0147663
LD45507 FBcl0178848
LD36580 FBcl0178859
LD35750 FBcl0178862
LP09865 FBcl0191728
LP08701 FBcl0191729
LP11772 FBcl0191730
LP03668 FBcl0191733
RE25143 FBcl0239085
RE28046 FBcl0239086
RE29270 FBcl0239087

3 Exons

DB identifier Symbol
FBgn0004926:2 eIF-2beta:2
FBgn0004926:3 eIF-2beta:3
FBgn0004926:1 eIF-2beta:1

1 Transcripts

DB identifier Gene
FBtr0075968 eIF-2beta

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0075968-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0075968-3-prime-utr Drosophila melanogaster

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43 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
39433 NCBI Entrez Gene identifiers FBgn0004926
64782 BioGRID FBgn0004926

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 6580.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 7578.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 3420.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 6891.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 7047.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 5921.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 7324.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 6731.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 7181.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 5488.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 5994.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 4158.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 5022.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 6515.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 6991.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 7454.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 6464.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 6445.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 7961.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 5898.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 6033.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 5760.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 4679.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 3548.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 6139.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 5702.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 1481.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 3583.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 3468.0
FBgn0004926 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 2688.0

2 Introns

DB identifier
Organism . Name
intron_FBgn0004926:3_FBgn0004926:2 Drosophila melanogaster
intron_FBgn0004926:2_FBgn0004926:1 Drosophila melanogaster

27 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage eIF-2beta Increased lipid droplet area 8.61116614   19067489
Lipid storage eIF-2beta Increased lipid droplet area 10.62227767   19067489
L. monocytogenes infection eIF-2beta Less vacuolar escape *   16157870
Constitutive protein secretion and Golgi organization (1) eIF-2beta Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) eIF-2beta none sp   16496002
NFAT signaling eIF-2beta Decreased NFAT translocation 3   16511445
C. trachomatis infection eIF-2beta C. trachomatis infection up np   18369471
Lipid storage eIF-2beta Normal/larger sized lipid droplets, highly condensed strong   18408709
Mutant human huntingtin aggregation eIF-2beta Decreased mutant human huntingtin aggregation <= -2   19789644
Muscle morphogenesis and function (1) eIF-2beta Lethal np   20220848
Muscle morphogenesis and function (2) eIF-2beta Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Serratia marcescens infection (1) eIF-2beta none -0.192307692307692   19520911
Serratia marcescens infection (1) eIF-2beta none -1.23214285714285   19520911
Serratia marcescens infection (2) eIF-2beta none sp   19520911
Serratia marcescens infection (6) eIF-2beta Larval lethality or failure to eclose np   19520911
Notch pathway regulation (4) eIF-2beta Completely lethal (before pupal) sp   19363474
Notch pathway regulation (4) eIF-2beta Completely lethal (before pupal) sp   19363474
PGN-induced dJNK phosphorylation eIF-2beta Increased P-JNK protein expression with PGN 2.72 15 min PGN induction 19893628
Adiposity regulation (1) eIF-2beta none -0.849   20074523
Adiposity regulation (1) eIF-2beta none >5   20074523
S2 cell spreading eIF-2beta none np   21041442
RTK-Ras-ERK pathway regulation (1) eIF-2beta Decreased ERK phosphorylation after EGF stimulation -2.42 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) eIF-2beta none -1.22 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) eIF-2beta none 0.37 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) eIF-2beta Increased ERK phosphorylation after sSpitz and EGF stimulation 2.31 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation eIF-2beta none -0.1   23263283
Glycosylation regulation (1) eIF-2beta Lethal np   21203496

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