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Gene : spn-E D. melanogaster

DB identifier  ? FBgn0003483 Secondary Identifier  ? CG3158
Name  ? spindle E Source  FlyBase
  • synonyms:
  • FBgn0004883,
  • Spindle E,
  • FBgn0003483,
  • FBan0003158,
  • spn-E/hls,
  • female sterile(3)homeless,
  • SpindleE,
  • homeless/spindle-E,
  • CG3158,
  • spn E,
  • fs(1)hls,
  • spin-E,
  • SpnE,
  • Spindle-E,
  • SPN-E,
  • hls,
  • hes,
  • Spindle-E (homeless),
  • HOMELESS,
  • fs(3)hls

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35 Alleles

DB identifier Symbol Allele Class Organism
FBal0243289 spn-E[tCH322-93D04]   Drosophila melanogaster
FBal0177689 spn-E[e04103]   Drosophila melanogaster
FBal0258703 spn-E[dsRNA.shRNA.Scer\UAS.P\T]   Drosophila melanogaster
FBal0245676 spn-E[JF01405]   Drosophila melanogaster
FBal0004296 spn-E[hls-03987] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0177690 spn-E[e03441]   Drosophila melanogaster
FBal0177691 spn-E[c07043]   Drosophila melanogaster
FBal0158610 spn-E[c00786]   Drosophila melanogaster
FBal0093780 spn-E[167R33] amorphic allele - genetic evidence Drosophila melanogaster
FBal0093781 spn-E[167R18]   Drosophila melanogaster
FBal0093782 spn-E[167] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0151414 spn-E[9A2-17]   Drosophila melanogaster
FBal0151416 spn-E[7G2-5]   Drosophila melanogaster
FBal0016042 spn-E[2] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0086324 spn-E[unspecified]   Drosophila melanogaster
FBal0151417 spn-E[4E2-14]   Drosophila melanogaster
FBal0016041 spn-E[1] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0154488 spn-E[hls-E1]   Drosophila melanogaster
FBal0154489 spn-E[DE8]   Drosophila melanogaster
FBal0045707 spn-E[hls-Delta139]   Drosophila melanogaster
FBal0045708 spn-E[hls-Delta157] loss of function allele Drosophila melanogaster
FBal0151418 spn-E[2A9-14]   Drosophila melanogaster
FBal0045706 spn-E[hls-Delta125] loss of function allele Drosophila melanogaster
FBal0151413 spn-E[9A9-18]   Drosophila melanogaster
FBal0151415 spn-E[8D4-11]   Drosophila melanogaster
FBal0262679 spn-E[GL00206]   Drosophila melanogaster
FBal0263122 spn-E[HMS00117]   Drosophila melanogaster
FBal0120333 spn-E[T:Uuuu\T7]   Drosophila melanogaster
FBal0218207 spn-E[D58]   Drosophila melanogaster
FBal0193425 spn-E[125]   Drosophila melanogaster

33 Clones

Secondary Identifier DB identifier
EK151039 FBcl0056660
CK01654 FBcl0060191
IP03663 FBcl0317420
IP03763 FBcl0319172
IP03863 FBcl0319173
IP03963 FBcl0319174
FGM321E10 FBcl0393625
RP004164037 FBcl0541274
RP004252132 FBcl0541277
RP004177803 FBcl0541286
RP004257601 FBcl0541289
RP004430887 FBcl0541296
RP004180611 FBcl0541299
RP004178554 FBcl0541300
RP004394487 FBcl0541301
RP004094296 FBcl0541305
RP004237204 FBcl0541308
RP004120062 FBcl0541313
RP004171435 FBcl0541320
RP004246114 FBcl0541322
RP004537884 FBcl0541324
RP004205358 FBcl0541325
RP004042001 FBcl0541328
RP004444415 FBcl0541335
RP004248147 FBcl0541339
RP004240366 FBcl0541340
RP004504120 FBcl0541346
RP004106336 FBcl0541347
RP004384232 FBcl0541348
RP004547222 FBcl0541350

11 Exons

DB identifier Symbol
FBgn0003483:1 spn-E:1
FBgn0003483:2 spn-E:2
FBgn0003483:3 spn-E:3
FBgn0003483:4 spn-E:4
FBgn0003483:5 spn-E:5
FBgn0003483:6 spn-E:6
FBgn0003483:10 spn-E:10
FBgn0003483:11 spn-E:11
FBgn0003483:7 spn-E:7
FBgn0003483:8 spn-E:8
FBgn0003483:9 spn-E:9

1 Transcripts

DB identifier Gene
FBtr0083183 spn-E

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0083183-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083183-3-prime-utr Drosophila melanogaster

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0 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
41919 NCBI Entrez Gene identifiers FBgn0003483
66977 BioGRID FBgn0003483

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 638.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 276.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 671.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 961.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1555.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 720.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 554.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 635.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 208.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1945.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 616.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 513.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 825.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 386.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 609.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 837.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 967.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 965.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 752.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 404.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1079.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 372.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1028.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 766.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 546.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 2138.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 970.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 260.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 115.0
FBgn0003483 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 187.0

10 Introns

DB identifier
Organism . Name
intron_FBgn0003483:1_FBgn0003483:2 Drosophila melanogaster
intron_FBgn0003483:2_FBgn0003483:3 Drosophila melanogaster
intron_FBgn0003483:3_FBgn0003483:4 Drosophila melanogaster
intron_FBgn0003483:4_FBgn0003483:5 Drosophila melanogaster
intron_FBgn0003483:5_FBgn0003483:6 Drosophila melanogaster
intron_FBgn0003483:6_FBgn0003483:7 Drosophila melanogaster
intron_FBgn0003483:7_FBgn0003483:8 Drosophila melanogaster
intron_FBgn0003483:8_FBgn0003483:9 Drosophila melanogaster
intron_FBgn0003483:9_FBgn0003483:10 Drosophila melanogaster
intron_FBgn0003483:10_FBgn0003483:11 Drosophila melanogaster

17 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage spn-E none 1.736605893   19067489
Lipid storage spn-E none 0.346047258   19067489
Alternative splicing spn-E none sp   15492211
Muscle morphogenesis and function (1) spn-E none np   20220848
Muscle morphogenesis and function (1) spn-E none np   20220848
Heat nociception (1) spn-E none -1.17   21074052
Heart development and function (1) spn-E none 1   20371351
Serratia marcescens infection (1) spn-E none 0.583333333333333   19520911
Notch pathway regulation (4) spn-E none 0   19363474
Notch pathway regulation (4) spn-E none 0   19363474
Adiposity regulation (1) spn-E none 1.113   20074523
RTK-Ras-ERK pathway regulation (1) spn-E none -0.24 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) spn-E none -0.33 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) spn-E none -0.37 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) spn-E Decreased ERK phosphorylation after sSpitz and EGF stimulation -1.61 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation spn-E none -0.41   23263283
Glycosylation regulation (1) spn-E none sp   21203496

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