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Gene : Spt5 D. melanogaster

DB identifier  ? FBgn0040273 Secondary Identifier  ? CG7626
Name  ? Spt5 Source  FlyBase
  • synonyms:
  • dDSIF,
  • CG7626,
  • FBan0007626,
  • Complementation group C,
  • Dspt5,
  • SPT5,
  • FBgn0034445,
  • FBgn0040273,
  • DSIF

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16 Alleles

DB identifier Symbol Allele Class Organism
FBal0284001 Spt5[Q314X]   Drosophila melanogaster
FBal0284002 Spt5[E471Z]   Drosophila melanogaster
FBal0284003 Spt5[A680Z]   Drosophila melanogaster
FBal0284004 Spt5[S14F]   Drosophila melanogaster
FBal0284005 Spt5[880C]   Drosophila melanogaster
FBal0196106 Spt5[SIE-27]   Drosophila melanogaster
FBal0155791 Spt5[MGE-3]   Drosophila melanogaster
FBal0175799 Spt5[W049]   Drosophila melanogaster
FBal0286762 Spt5[Scer\UAS.ORF]   Drosophila melanogaster
FBal0286763 Spt5[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0263150 Spt5[HMS00153]   Drosophila melanogaster
FBal0208611 Spt5[GD4075]   Drosophila melanogaster
FBal0231185 Spt5[KK101304]   Drosophila melanogaster
FBal0275647 Spt5[NIG.7626R]   Drosophila melanogaster
FBal0280005 Spt5[N30]   Drosophila melanogaster
FBal0280006 Spt5[unspecified]   Drosophila melanogaster

83 Clones

Secondary Identifier DB identifier
AT16058 FBcl0037601
AT09847 FBcl0037605
AT09766 FBcl0037621
EK253559 FBcl0027698
EK168542 FBcl0027708
EK021015 FBcl0027718
EK127962 FBcl0027780
EK091823 FBcl0027850
EK126662 FBcl0027880
EK117838 FBcl0027896
EK175914 FBcl0027906
GH15359 FBcl0136591
GH16137 FBcl0136593
GH22129 FBcl0136655
GH15287 FBcl0136657
LD09135 FBcl0162724
LD08338 FBcl0162850
LD18628 FBcl0162851
LD10265 FBcl0162892
LD26815 FBcl0178841
LD24382 FBcl0178896
LD30837 FBcl0178908
LD43311 FBcl0178923
LD29617 FBcl0178924
LD32990 FBcl0178925
LD47281 FBcl0178926
LD23279 FBcl0179022
RE58135 FBcl0239068
RE70239 FBcl0239114
RE70937 FBcl0239127

12 Exons

DB identifier Symbol
FBgn0040273:1 Spt5:1
FBgn0040273:2 Spt5:2
FBgn0040273:3 Spt5:3
FBgn0040273:4 Spt5:4
FBgn0040273:5 Spt5:5
FBgn0040273:6 Spt5:6
FBgn0040273:7 Spt5:7
FBgn0040273:8 Spt5:8
FBgn0040273:9 Spt5:9
FBgn0040273:10 Spt5:10
FBgn0040273:11 Spt5:11
FBgn0040273:12 Spt5:12

1 Transcripts

DB identifier Gene
FBtr0086531 Spt5

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0086531-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0086531-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
53442 NCBI Entrez Gene identifiers FBgn0040273
72729 BioGRID FBgn0040273

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1326.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1012.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 956.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1168.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1463.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 509.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 783.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 944.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1187.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1143.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 871.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 704.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 714.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 895.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1102.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 805.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 848.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 865.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1008.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 864.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1130.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1022.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 962.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1346.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 1020.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 2085.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2250.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1936.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1438.0
FBgn0040273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1429.0

11 Introns

DB identifier
Organism . Name
intron_FBgn0040273:1_FBgn0040273:2 Drosophila melanogaster
intron_FBgn0040273:2_FBgn0040273:3 Drosophila melanogaster
intron_FBgn0040273:3_FBgn0040273:4 Drosophila melanogaster
intron_FBgn0040273:4_FBgn0040273:5 Drosophila melanogaster
intron_FBgn0040273:5_FBgn0040273:6 Drosophila melanogaster
intron_FBgn0040273:6_FBgn0040273:7 Drosophila melanogaster
intron_FBgn0040273:7_FBgn0040273:8 Drosophila melanogaster
intron_FBgn0040273:8_FBgn0040273:9 Drosophila melanogaster
intron_FBgn0040273:9_FBgn0040273:10 Drosophila melanogaster
intron_FBgn0040273:10_FBgn0040273:11 Drosophila melanogaster
intron_FBgn0040273:11_FBgn0040273:12 Drosophila melanogaster

30 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Spt5 none -1.882261949   19067489
Lipid storage Spt5 none 0.549825064   19067489
ERK signaling Spt5 ERK activation increased weak   17086199
Intracellular Listeria monocytogenes infection Spt5 Decreased GFP protein expression weak   16020693
Constitutive protein secretion and Golgi organization (1) Spt5 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Spt5 none sp   16496002
Candida albicans phagocytosis (1) Spt5 none np   16336044
Dendrite pattern formation Spt5 none np   16547170
Mitosis Spt5 Chromosome misalignment np   17412918
Combinatorial effect with methyl methanesulphonate (1) Spt5 none sp   19543366
Mutant human huntingtin aggregation Spt5 Increased mutant human huntingtin aggregation >= 2   19789644
Muscle morphogenesis and function (1) Spt5 Lethal np   20220848
Muscle morphogenesis and function (2) Spt5 Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Muscle morphogenesis and function (3) Spt5 Split myofibril, spotty (discontinuous) Z-line np   20220848
Heat nociception (1) Spt5 none -1.17   21074052
Heart development and function (1) Spt5 none 1   20371351
Serratia marcescens infection (1) Spt5 none 0.444444444444444   19520911
Notch pathway regulation (4) Spt5 Colour defects, notum malformation migration sp   19363474
G2-M DNA damage checkpoint regulation (2) Spt5 Increased histone H3 phosphorylation with doxorubicin 58.15 with doxorubicin 21205937
G2-M DNA damage checkpoint regulation (2) Spt5 Increased histone H3 phosphorylation with etoposide 26.07 with etoposide 21205937
G2-M DNA damage checkpoint regulation (2) Spt5 none 30.75 X-ray exposure 21205937
G2-M DNA damage checkpoint regulation (2) Spt5 Increased histone H3 phosphorylation with bleocin 16.45 with bleocin 21205937
Pol II elongation Spt5 none 70 20 min heat shock 19279664
Adiposity regulation (1) Spt5 none -0.101   20074523
RTK-Ras-ERK pathway regulation (1) Spt5 none 0.47 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Spt5 none -0.49 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Spt5 none 0.04 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Spt5 none 1.05 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation Spt5 none 0.64   23263283
Glycosylation regulation (1) Spt5 none sp   21203496

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