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Gene : Pka-C1 D. melanogaster

DB identifier  ? FBgn0000273 Secondary Identifier  ? CG4379
Name  ? cAMP-dependent protein kinase 1 Source  FlyBase
  • synonyms:
  • DCO,
  • l(2)cos[[1]],
  • cAMP-dependent protein kinase,
  • PKAC1,
  • PKAcA,
  • Pka-C,
  • CG4379,
  • Cos-1,
  • FBgn0010695,
  • CdkA,
  • Protein Kinase A,
  • Dcpk,
  • 6353,
  • DC0,
  • PKAc,
  • C,
  • FBgn0000273,
  • PKA,
  • catalytic subunit of PKA,
  • FBan0004379,
  • Cos,
  • Cos1,
  • FBgn0000353,
  • PKA catalytic subunit,
  • Costal,
  • PKA Cl,
  • unnamed,
  • Costal-1,
  • cAMP-dependent protein kinase A,
  • catalytic subunit of cAMP-dependent protein kinase,
  • l(2)s4402,
  • dPKA,
  • pka C1,
  • PKA CI,
  • PKA-C1,
  • l(2)01272

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93 Alleles

DB identifier Symbol Allele Class Organism
FBal0281890 Pka-C1[MI07503]   Drosophila melanogaster
FBal0212187 Pka-C1[Act5C.T:Ivir\HA1]   Drosophila melanogaster
FBal0211941 Pka-C1[CB03724]   Drosophila melanogaster
FBal0284281 Pka-C1[G2532] hypomorphic allele - molecular evidence Drosophila melanogaster
FBal0245480 Pka-C1[JF01188]   Drosophila melanogaster
FBal0245510 Pka-C1[JF01218]   Drosophila melanogaster
FBal0182258 Pka-C1[f00909]   Drosophila melanogaster
FBal0182256 Pka-C1[f06704]   Drosophila melanogaster
FBal0182257 Pka-C1[f00921]   Drosophila melanogaster
FBal0182259 Pka-C1[e02391]   Drosophila melanogaster
FBal0045003 Pka-C1[k11302]   Drosophila melanogaster
FBal0030039 Pka-C1[MB581] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0065028 Pka-C1[k06118]   Drosophila melanogaster
FBal0042709 Pka-C1[rM692]   Drosophila melanogaster
FBal0013846 Pka-C1[01272]   Drosophila melanogaster
FBal0009317 Pka-C1[s4402]   Drosophila melanogaster
FBal0042700 Pka-C1[k16718]   Drosophila melanogaster
FBal0042701 Pka-C1[01242]   Drosophila melanogaster
FBal0042702 Pka-C1[06353] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0042703 Pka-C1[07162]   Drosophila melanogaster
FBal0042704 Pka-C1[k00228]   Drosophila melanogaster
FBal0042705 Pka-C1[k00804]   Drosophila melanogaster
FBal0042706 Pka-C1[k06108]   Drosophila melanogaster
FBal0042707 Pka-C1[k08008]   Drosophila melanogaster
FBal0042708 Pka-C1[k08918] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0042710 Pka-C1[rN167]   Drosophila melanogaster
FBal0101590 Pka-C1[61]   Drosophila melanogaster
FBal0125374 Pka-C1[BG02142]   Drosophila melanogaster
FBal0278223 Pka-C1[K2]   Drosophila melanogaster
FBal0213213 Pka-C1[76a3]   Drosophila melanogaster

116 Clones

Secondary Identifier DB identifier
Dmel_neb_007753_0597_2503 FBcl0373474
Dmel_neb_010994_0656_1821 FBcl0373475
Dmel_dig_011705_0621_3029 FBcl0373476
Dmel_neb_007569_0906_2973 FBcl0373477
DPiM_LD13640 FBcl0741938
Dmel_neb_009170_0616_2007 FBcl0373478
Dmel_neb_014196_0837_2516 FBcl0373479
EK158043 FBcl0036112
EK249301 FBcl0036134
EK296238 FBcl0036152
EK056336 FBcl0036170
UUGC0042 FBcl0001131
EK191814 FBcl0036190
EK198929 FBcl0036212
EK066457 FBcl0036232
EK200509 FBcl0036252
EK229209 FBcl0036272
EK194718 FBcl0036290
EK209142 FBcl0037402
EK047514 FBcl0036310
EK217239 FBcl0036330
EK306943 FBcl0036348
EK261317 FBcl0036368
EK132017 FBcl0036386
EK192216 FBcl0037636
ESG012c.E21_H05 FBcl0010605
EK155226 FBcl0035804
EK184743 FBcl0035902
EK050512 FBcl0035960
EK191907 FBcl0035980

6 Exons

DB identifier Symbol
FBgn0000273:6 Pka-C1:6
FBgn0000273:3 Pka-C1:3
FBgn0000273:1 Pka-C1:1
FBgn0000273:4 Pka-C1:4
FBgn0000273:5 Pka-C1:5
FBgn0000273:2 Pka-C1:2

3 Transcripts

DB identifier Gene
FBtr0079852 Pka-C1
FBtr0079851 Pka-C1
FBtr0335495 Pka-C1

6 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0079851-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0079852-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0335495-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0079851-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0079852-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0335495-3-prime-utr Drosophila melanogaster

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60 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
34284 NCBI Entrez Gene identifiers FBgn0000273
60383 BioGRID FBgn0000273

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 637.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 601.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 560.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 545.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 400.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 689.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 808.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 703.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 532.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 992.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1185.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 487.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 500.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 879.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 652.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 413.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1019.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 1076.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 461.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 637.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 551.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 939.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 500.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 724.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 775.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 2380.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2229.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1413.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 979.0
FBgn0000273 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 869.0

6 Introns

DB identifier
Organism . Name
intron_FBgn0000273:6_FBgn0000273:4 Drosophila melanogaster
intron_FBgn0000273:4_FBgn0000273:1 Drosophila melanogaster
intron_FBgn0000273:6_FBgn0000273:3 Drosophila melanogaster
intron_FBgn0000273:3_FBgn0000273:1 Drosophila melanogaster
intron_FBgn0000273:5_FBgn0000273:3 Drosophila melanogaster
intron_FBgn0000273:3_FBgn0000273:2 Drosophila melanogaster

36 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Pka-C1 none 1.539939995   19067489
Lipid storage Pka-C1 none -1.240696481   19067489
Lipid storage Pka-C1 none 0.643333546   19067489
Lipid storage Pka-C1 none -0.468472697   19067489
ERK signaling Pka-C1 ERK activation reduced moderate   17086199
Hedgehog signaling Pka-C1 Increased Hedgehog reporter activity np   12663920
Cell cycle regulation (1) Pka-C1 none np   15616552
Cell cycle regulation (2) Pka-C1 none np   15616552
Hedgehog signaling Pka-C1 Decreased Hedgehog reporter activity -2.07   16311596
Cell size and cell-cycle regulation (1) Pka-C1 none sp   16496002
Cell size and cell-cycle regulation (1) Pka-C1 none sp   16496002
Muscle morphogenesis and function (1) Pka-C1 Flightless np   20220848
Muscle morphogenesis and function (2) Pka-C1 Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Muscle morphogenesis and function (4) Pka-C1 none np   20220848
Heat nociception (1) Pka-C1 none 1.04   21074052
Heart development and function (1) Pka-C1 none 0.8   20371351
Heart development and function (2) Pka-C1 Decreased viability 3.55   20371351
Serratia marcescens infection (1) Pka-C1 none -0.231481481481481   19520911
Notch pathway regulation (4) Pka-C1 Planar polarity defects, notum malformation migration sp   19363474
Hh pathway regulation Pka-C1 Downregulation of Hh pathway -0.312478857024627   17903264
Hh pathway regulation Pka-C1 none -0.221287352078871   17903264
Adiposity regulation (1) Pka-C1 none -0.304   20074523
Actin organization and cell morphology (1) Pka-C1 none np   19265526
Actin organization and cell morphology (2) Pka-C1 none np   19265526
Actin organization and cell morphology (3) Pka-C1 none np   19265526
Actin organization and cell morphology (4) Pka-C1 none np   19265526
Actin organization and cell morphology (5) Pka-C1 none np   19265526
Actin organization and cell morphology (6) Pka-C1 none np   19265526
Vaccinia virus infection Pka-C1 none sp   20585561
RTK-Ras-ERK pathway regulation (1) Pka-C1 none 0.08 0 minutes EGF stimulation 22028469

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