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Gene : Dsor1 D. melanogaster

DB identifier  ? FBgn0010269 Secondary Identifier  ? CG15793
Name  ? Downstream of raf1 Source  FlyBase
  • synonyms:
  • MAPK kinase,
  • FBgn0010269,
  • MAPKK,
  • MEK1/2,
  • MEK,
  • D-MEK/Dsor,
  • DMEK-1,
  • DSOR1,
  • Su(Raf)34B,
  • DSORT,
  • D-MEK,
  • D-sor-1,
  • Dmek,
  • downstream suppressor of Raf 1,
  • DRODSOR1,
  • MEK/Dsor1,
  • SOR,
  • D-SOR,
  • DSor,
  • CG15793,
  • mitogen-activated protein kinase kinase,
  • Drosophila MEK,
  • sor/MEK1,
  • FBan0015793,
  • MAP Kinase Kinase,
  • EK1-1

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43 Alleles

DB identifier Symbol Allele Class Organism
FBal0257080 Dsor1[HMS00037]   Drosophila melanogaster
FBal0248602 Dsor1[G9740]   Drosophila melanogaster
FBal0245899 Dsor1[JF01697]   Drosophila melanogaster
FBal0257393 Dsor1[HMS00710]   Drosophila melanogaster
FBal0248867 Dsor1[VDRC.cUa]   Drosophila melanogaster
FBal0039031 Dsor1[Gp158]   Drosophila melanogaster
FBal0039036 Dsor1[r1]   Drosophila melanogaster
FBal0060718 Dsor1[MAPKK]   Drosophila melanogaster
FBal0039029 Dsor1[+t9]   Drosophila melanogaster
FBal0039030 Dsor1[D83V]   Drosophila melanogaster
FBal0039038 Dsor1[ts1]   Drosophila melanogaster
FBal0039039 Dsor1[ts2]   Drosophila melanogaster
FBal0061976 Dsor1[Su12]   Drosophila melanogaster
FBal0091830 Dsor1[756]   Drosophila melanogaster
FBal0061970 Dsor1[Su5]   Drosophila melanogaster
FBal0148060 Dsor1[G42]   Drosophila melanogaster
FBal0048254 Dsor1[S-1221]   Drosophila melanogaster
FBal0039033 Dsor1[Su1] gain of function allele, hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0104860 Dsor1[unspecified]   Drosophila melanogaster
FBal0117835 Dsor1[dsRNA.cCa]   Drosophila melanogaster
FBal0039032 Dsor1[LH110] amorphic allele - genetic evidence, loss of function allele Drosophila melanogaster
FBal0061974 Dsor1[Su24]   Drosophila melanogaster
FBal0148059 Dsor1[G79]   Drosophila melanogaster
FBal0042752 Dsor1[LF133]   Drosophila melanogaster
FBal0039037 Dsor1[r2]   Drosophila melanogaster
FBal0061969 Dsor1[Su6]   Drosophila melanogaster
FBal0104319 Dsor1[1]   Drosophila melanogaster
FBal0039034 Dsor1[Su34B]   Drosophila melanogaster
FBal0061968 Dsor1[Su7]   Drosophila melanogaster
FBal0061975 Dsor1[Su18]   Drosophila melanogaster

21 Clones

Secondary Identifier DB identifier
DPiM_LD41207 FBcl0741951
ESG014b.E21_D07 FBcl0008613
EK066844 FBcl0116718
LD05838 FBcl0156778
LD41207 FBcl0170647
EC052375 FBcl0298737
EC056305 FBcl0298730
EC056208 FBcl0298731
EC056072 FBcl0298732
EC055338 FBcl0298733
EC055040 FBcl0298734
EC055023 FBcl0298735
EC053844 FBcl0298736
EC051294 FBcl0298738
EC055890 FBcl0298739
Dmel_dig_017906_0680_2891 FBcl0365435
CK01.98B.E7 FBcl0414647
CK01.118A.D5 FBcl0414658
CK01.84A.C12 FBcl0414670
RP004235055 FBcl0497261
RP004362344 FBcl0497262

7 Exons

DB identifier Symbol
FBgn0010269:1 Dsor1:1
FBgn0010269:3 Dsor1:3
FBgn0010269:5 Dsor1:5
FBgn0010269:6 Dsor1:6
FBgn0010269:2 Dsor1:2
FBgn0010269:4 Dsor1:4
FBgn0010269:7 Dsor1:7

2 Transcripts

DB identifier Gene
FBtr0071313 Dsor1
FBtr0340120 Dsor1

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0071313-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0340120-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0071313-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0340120-3-prime-utr Drosophila melanogaster

Interactions

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Other

83 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
31872 NCBI Entrez Gene identifiers FBgn0010269
58322 BioGRID FBgn0010269

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 621.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 536.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 549.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 810.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 599.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 399.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 914.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 450.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 421.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 665.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 666.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 418.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 521.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 609.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 566.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 362.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 954.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 638.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 783.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 443.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 547.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 541.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 451.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 399.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 560.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 2222.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 731.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 894.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 660.0
FBgn0010269 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 521.0

6 Introns

DB identifier
Organism . Name
intron_FBgn0010269:2_FBgn0010269:4 Drosophila melanogaster
intron_FBgn0010269:4_FBgn0010269:5 Drosophila melanogaster
intron_FBgn0010269:5_FBgn0010269:7 Drosophila melanogaster
intron_FBgn0010269:1_FBgn0010269:3 Drosophila melanogaster
intron_FBgn0010269:3_FBgn0010269:5 Drosophila melanogaster
intron_FBgn0010269:5_FBgn0010269:6 Drosophila melanogaster

32 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Cell size regulation Dsor1 Decreased cell size -2.02   19216764
Lipid storage Dsor1 none 0.467793418   19067489
Lipid storage Dsor1 none -1.222167663   19067489
Lipid storage Dsor1 none 0.416375816   19067489
Lipid storage Dsor1 none 0.359251412   19067489
ERK signaling Dsor1 ERK activation reduced strong   17086199
Cell morphology Dsor1 Morphology np   14527345
Cell cycle regulation (1) Dsor1 none np   15616552
Cell cycle regulation (2) Dsor1 none np   15616552
Cell size and cell-cycle regulation (1) Dsor1 none sp   16496002
Cell size and cell-cycle regulation (1) Dsor1 none sp   16496002
Muscle morphogenesis and function (1) Dsor1 Lethal np   20220848
Muscle morphogenesis and function (1) Dsor1 Lethal np   20220848
Heat nociception (1) Dsor1 none -1.17   21074052
Heart development and function (1) Dsor1 none 1   20371351
Serratia marcescens infection (1) Dsor1 none 0.541176470588235   19520911
Notch pathway regulation (4) Dsor1 Completely lethal (pupal) sp   19363474
Notch pathway regulation (4) Dsor1 Notum malformation death 7   19363474
Adiposity regulation (1) Dsor1 none -0.283   20074523
S2 cell spreading Dsor1 none np   21041442
Actin organization and cell morphology (1) Dsor1 none np   19265526
Actin organization and cell morphology (2) Dsor1 none np   19265526
Actin organization and cell morphology (3) Dsor1 none np   19265526
Actin organization and cell morphology (4) Dsor1 Altered cell morphology np   19265526
Actin organization and cell morphology (5) Dsor1 Altered cell morphology np   19265526
Actin organization and cell morphology (6) Dsor1 Altered cell morphology np   19265526
Vaccinia virus infection Dsor1 none sp   20585561
RTK-Ras-ERK pathway regulation (1) Dsor1 Decreased ERK phosphorylation after EGF stimulation -2.02 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Dsor1 Decreased ERK phosphorylation after EGF stimulation -1.89 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Dsor1 Decreased ERK phosphorylation after sSpitz and EGF stimulation -5.42 10 minutes sSpitz stimulation 22028469

0 Submissions