Genomics
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74 Alleles
163 Clones
20 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0020386:5 | Pdk1:5 |
| FBgn0020386:7 | Pdk1:7 |
| FBgn0020386:8 | Pdk1:8 |
| FBgn0020386:14 | Pdk1:14 |
| FBgn0020386:15 | Pdk1:15 |
| FBgn0020386:16 | Pdk1:16 |
| FBgn0020386:9 | Pdk1:9 |
| FBgn0020386:13 | Pdk1:13 |
| FBgn0020386:10 | Pdk1:10 |
| FBgn0020386:11 | Pdk1:11 |
| FBgn0020386:19 | Pdk1:19 |
| FBgn0020386:12 | Pdk1:12 |
| FBgn0020386:1 | Pdk1:1 |
| FBgn0020386:18 | Pdk1:18 |
| FBgn0020386:4 | Pdk1:4 |
| FBgn0020386:2 | Pdk1:2 |
| FBgn0020386:6 | Pdk1:6 |
| FBgn0020386:3 | Pdk1:3 |
| FBgn0020386:17 | Pdk1:17 |
| FBgn0020386:20 | Pdk1:20 |
10 Transcripts
| DB identifier | Gene |
|---|---|
| FBtr0072468 | Pdk1 |
| FBtr0072467 | Pdk1 |
| FBtr0333218 | Pdk1 |
| FBtr0072466 | Pdk1 |
| FBtr0072464 | Pdk1 |
| FBtr0072465 | Pdk1 |
| FBtr0302599 | Pdk1 |
| FBtr0072470 | Pdk1 |
| FBtr0072469 | Pdk1 |
| FBtr0072471 | Pdk1 |
18 UTRs
Other
74 Pathways
- PI3K/AKT activation,
- Phospholipid metabolism,
- Immune System,
- Synthesis of PIPs at the plasma membrane,
- GAB1 signalosome,
- Role of LAT2/NTAL/LAB on calcium mobilization,
- TCR signaling,
- Insulin signaling pathway,
- RSK activation,
- Fc epsilon receptor (FCERI) signaling,
- Signaling by ERBB4,
- GPVI-mediated activation cascade,
- Innate Immune System,
- TOR signaling pathway,
- Downstream Signaling Events Of B Cell Receptor (BCR),
- Adaptive Immune System,
- G beta:gamma signalling through PI3Kgamma,
- Negative regulation of the PI3K/AKT network,
- CTLA4 inhibitory signaling,
- Activation of PKB,
- DAP12 interactions,
- IRS activation,
- CD28 co-stimulation,
- Insulin receptor recycling,
- Insulin receptor mediated signaling,
- IGF1R signaling cascade,
- Signaling by FGFR in disease,
- Signaling Pathways,
- Transmission across Chemical Synapses,
- Activation of NMDA receptor upon glutamate binding and postsynaptic events,
- CREB phosphorylation through the activation of Ras,
- Downstream TCR signaling,
- G-protein beta:gamma signalling,
- Downstream signaling of activated FGFR,
- Insulin receptor signalling cascade,
- Signal amplification,
- Costimulation by the CD28 family,
- Neuronal System,
- GPCR downstream signaling,
- DAP12 signaling,
- Signaling by GPCR,
- Antigen Activates B Cell Receptor Leading to Generation of Second Messengers,
- B Cell Activation,
- Hemostasis,
- PI3K Cascade,
- Platelet activation, signaling and aggregation,
- DINR-mediated activation,
- Metabolism of lipids and lipoproteins,
- Signaling by ERBB2,
- Constitutive PI3K/AKT Signaling in Cancer,
- Signaling by EGFR,
- CD28 dependent PI3K/Akt signaling,
- PI3K/AKT Signaling in Cancer,
- Post NMDA receptor activation events,
- Downstream signal transduction,
- NGF signalling via TRKA from the plasma membrane,
- IRS-mediated signalling,
- Metabolism,
- PI-3K cascade,
- Disease,
- Signaling by SCF-KIT,
- Platelet Aggregation (Plug Formation),
- PI3K events in ERBB4 signaling,
- IRS-related events,
- Signaling by NGF,
- Signaling by EGFR in Cancer,
- Signaling by FGFR,
- IRS-related events triggered by IGF1R,
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell,
- PI Metabolism,
- Signaling by PDGF,
- PIP3 activates AKT signaling,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- PI3K events in ERBB2 signaling
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 38017 | NCBI Entrez Gene identifiers | FBgn0020386 |
| 63582 | BioGRID | FBgn0020386 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
20 Introns
45 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Cell size regulation | Pdk1 | none | -1.13 | 19216764 | |
| Lipid storage | Pdk1 | Increased lipid droplet area | 2.372550174 | 19067489 | |
| Lipid storage | Pdk1 | Increased lipid droplet area | 6.439134592 | 19067489 | |
| ERK signaling | Pdk1 | ERK activation increased | strong | 17086199 | |
| Cell cycle regulation (1) | Pdk1 | Increased G1 DNA content, decreased cell size, decreased mitotic index | sp | 15616552 | |
| Cell cycle regulation (2) | Pdk1 | Increased G1 DNA content, decreased cell size | np | 15616552 | |
| Cell size and cell-cycle regulation (1) | Pdk1 | Increased G1 DNA content | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | Pdk1 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | Pdk1 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | Pdk1 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | Pdk1 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | Pdk1 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | Pdk1 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | Pdk1 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | Pdk1 | none | 1.321 | 16496002 | |
| Cell size and cell-cycle regulation (3) | Pdk1 | none | 452 | 16496002 | |
| DFoxO signaling | Pdk1 | Decreased dFoxO reporter activity | 0.001 | 18815370 | |
| Lipid storage | Pdk1 | Altered mean signal | automated analysis | 18408709 | |
| Combinatorial effect with methyl methanesulphonate (2) | Pdk1 | Synthetic lethal with methyl methanesulphonate | sp | 19543366 | |
| Muscle morphogenesis and function (1) | Pdk1 | none | np | 20220848 | |
| Heat nociception (1) | Pdk1 | none | -0.14 | 21074052 | |
| Heart development and function (1) | Pdk1 | none | 1 | 20371351 | |
| Heart development and function (2) | Pdk1 | Decreased viability | 5.45 | 20371351 | |
| Serratia marcescens infection (1) | Pdk1 | none | 0.929577464788732 | 19520911 | |
| Notch pathway regulation (4) | Pdk1 | Notum malformation migration | 0.6 | 19363474 | |
| Akt-TOR pathway negative feedback regulation | Pdk1 | Increased dAkt phosphorylation | 4.8 | without insulin stimulation | 20585550 |
| Akt-TOR pathway negative feedback regulation | Pdk1 | none | 2.5 | 10 min insulin stimulation | 20585550 |
| Adiposity regulation (1) | Pdk1 | none | -0.327 | 20074523 | |
| Actin organization and cell morphology (1) | Pdk1 | none | np | 19265526 | |
| Actin organization and cell morphology (2) | Pdk1 | none | np | 19265526 |
