Genomics
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6 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0286421 | RpS4[Scer\UAS.ORF] | Drosophila melanogaster | |
| FBal0286422 | RpS4[Scer\UAS.ORF.T:Ivir\HA1] | Drosophila melanogaster | |
| FBal0270805 | RpS4[NIG.11276R] | Drosophila melanogaster | |
| FBal0208390 | RpS4[GD13437] | Drosophila melanogaster | |
| FBal0208391 | RpS4[GD17217] | Drosophila melanogaster | |
| FBal0235920 | RpS4[KK108912] | Drosophila melanogaster |
823 Clones
7 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0011284:1 | RpS4:1 |
| FBgn0011284:3 | RpS4:3 |
| FBgn0011284:4 | RpS4:4 |
| FBgn0011284:5 | RpS4:5 |
| FBgn0011284:6 | RpS4:6 |
| FBgn0011284:7 | RpS4:7 |
| FBgn0011284:2 | RpS4:2 |
4 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0075884-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0075885-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0075884-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0075885-3-prime-utr | Drosophila melanogaster |
Other
52 Pathways
- Transcription,
- SRP-dependent cotranslational protein targeting to membrane,
- Formation of the ternary complex, and subsequently, the 43S complex,
- Eukaryotic Translation Initiation,
- Recycling of eIF2:GDP,
- Nonsense-Mediated Decay,
- Formation of RNA Pol II elongation complex,
- Gene Expression,
- Metabolism of RNA,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- Transport of Mature Transcript to Cytoplasm,
- Elongation arrest and recovery,
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- Formation of the Early Elongation Complex,
- Transport of the SLBP Dependant Mature mRNA,
- Cleavage of Growing Transcript in the Termination Region,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- Eukaryotic Translation Termination,
- SLBP independent Processing of Histone Pre-mRNAs,
- Processing of Intronless Pre-mRNAs,
- Cap-dependent Translation Initiation,
- Nonsense Mediated Decay Independent of the Exon Junction Complex,
- RNA Polymerase II Transcription Termination,
- Metabolism of mRNA,
- RNA Polymerase II Transcription Initiation,
- Post-Elongation Processing of Intronless pre-mRNA,
- mRNA Capping,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- Nonsense Mediated Decay Enhanced by the Exon Junction Complex,
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- RNA Polymerase II Pre-transcription Events,
- mRNA Processing,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- Metabolism of proteins,
- RNA Polymerase II Transcription,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- Eukaryotic Translation Elongation,
- Translation initiation complex formation,
- Formation of a pool of free 40S subunits,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- Transport of the SLBP independent Mature mRNA,
- RNA Polymerase II Promoter Escape,
- Processing of Capped Intron-Containing Pre-mRNA,
- Processing of Capped Intronless Pre-mRNA,
- Peptide chain elongation,
- 3' -UTR-mediated translational regulation,
- Ribosomal scanning and start codon recognition,
- RNA Pol II CTD phosphorylation and interaction with CE,
- RNA Polymerase II Transcription Elongation,
- Translation,
- Post-Elongation Processing of the Transcript
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 39484 | NCBI Entrez Gene identifiers | FBgn0011284 |
| 64829 | BioGRID | FBgn0011284 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
6 Introns
29 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | RpS4 | Increased lipid droplet area | 3.779997374 | 19067489 | |
| Lipid storage | RpS4 | Increased lipid droplet area | 4.239730341 | 19067489 | |
| Drosophila C virus infection | RpS4 | Drosophila C virus replication down | np | 17040126 | |
| Cytokinesis regulation | RpS4 | Binucleate cells with decreased viability | medium | 15547975 | |
| Intracellular Listeria monocytogenes infection | RpS4 | Increased GFP protein expression | moderate | 16020693 | |
| Drosophila C virus infection | RpS4 | Drosophila C virus infection reduced | np | 15713840 | |
| Hedgehog signaling | RpS4 | Decreased Hedgehog reporter activity | -2.9 | 16311596 | |
| Constitutive protein secretion and Golgi organization (1) | RpS4 | Decreased horseradish peroxidase protein expression | sp | 16452979 | |
| Candida albicans phagocytosis (1) | RpS4 | none | np | 16336044 | |
| Influenza replication | RpS4 | Decreased Influenza replication | -2.21/-2.78 | 18615016 | |
| Lipid storage | RpS4 | Smaller sized lipid droplets, more dispersed | strong | 18408709 | |
| Combinatorial effect with methyl methanesulphonate (2) | RpS4 | Synthetic lethal with methyl methanesulphonate | sp | 19543366 | |
| Muscle morphogenesis and function (1) | RpS4 | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (1) | RpS4 | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | RpS4 | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Muscle morphogenesis and function (3) | RpS4 | Split myofibril, fading Z-line | np | 20220848 | |
| Heat nociception (1) | RpS4 | Developmentally lethal | 0.12 | 21074052 | |
| Heart development and function (1) | RpS4 | Larval lethal | 0.17 | 20371351 | |
| Serratia marcescens infection (1) | RpS4 | none | -0.851851851851851 | 19520911 | |
| Notch pathway regulation (4) | RpS4 | Completely lethal (pupal) | sp | 19363474 | |
| Notch pathway regulation (4) | RpS4 | Completely lethal (pupal) | sp | 19363474 | |
| Hh pathway regulation | RpS4 | Downregulation of Hh pathway | -0.596155047395357 | 17903264 | |
| Hh pathway regulation | RpS4 | Downregulation of Hh pathway | -0.576824082030082 | 17903264 | |
| Adiposity regulation (1) | RpS4 | none | -0.315 | 20074523 | |
| RTK-Ras-ERK pathway regulation (1) | RpS4 | none | 0.16 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | RpS4 | Decreased ERK phosphorylation after EGF stimulation | -3.77 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | RpS4 | none | 1.26 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | RpS4 | Increased ERK phosphorylation after sSpitz and EGF stimulation | 3.2 | 30 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | RpS4 | none | 0.06 | 23263283 |
