Genomics
Gene Ontology Displayer
Homologue Displayer
Mod Mine G Browse Displayer
Overlapping Features Displayer
Regulatory Regions Displayer
45 Alleles
157 Clones
13 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0015218:9 | eIF-4E:9 |
| FBgn0015218:8 | eIF-4E:8 |
| FBgn0015218:13 | eIF-4E:13 |
| FBgn0015218:11 | eIF-4E:11 |
| FBgn0015218:10 | eIF-4E:10 |
| FBgn0015218:5 | eIF-4E:5 |
| FBgn0015218:4 | eIF-4E:4 |
| FBgn0015218:3 | eIF-4E:3 |
| FBgn0015218:2 | eIF-4E:2 |
| FBgn0015218:1 | eIF-4E:1 |
| FBgn0015218:6 | eIF-4E:6 |
| FBgn0015218:7 | eIF-4E:7 |
| FBgn0015218:12 | eIF-4E:12 |
18 UTRs
Other
71 Pathways
- Formation of the Early Elongation Complex,
- mTOR signalling,
- Formation of a pool of free 40S subunits,
- SLBP independent Processing of Histone Pre-mRNAs,
- Deadenylation-dependent mRNA decay,
- 3' -UTR-mediated translational regulation,
- Release of eIF4E,
- Interferon Signaling,
- Transport of the SLBP independent Mature mRNA,
- Metabolism of RNA,
- Transport of Mature Transcript to Cytoplasm,
- Post-Elongation Processing of the Transcript,
- Transport of the SLBP Dependant Mature mRNA,
- Ribosomal scanning and start codon recognition,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- RNA Polymerase II Transcription Termination,
- Eukaryotic Translation Initiation,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- Gene Expression,
- mRNA Capping,
- IRS-related events triggered by IGF1R,
- TOR signaling pathway,
- mTORC1-mediated signalling,
- Regulation of Rheb GTPase activity by AMPK,
- Immune System,
- Elongation arrest and recovery,
- Insulin receptor signalling cascade,
- Cap-dependent Translation Initiation,
- IRS-related events,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- RNA Polymerase II Pre-transcription Events,
- Signaling Pathways,
- IRS activation,
- RNA Polymerase II Transcription Initiation,
- RNA Polymerase II Promoter Escape,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- Transcription,
- Translation initiation complex formation,
- Energy dependent regulation of mTOR by LKB1-AMPK,
- RNA Polymerase II Transcription,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- RNA Polymerase II Transcription Elongation,
- Antiviral mechanism by IFN-stimulated genes,
- Deadenylation of mRNA,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- PI3K Cascade,
- RNA Pol II CTD phosphorylation and interaction with CE,
- DINR-mediated activation,
- Processing of Capped Intronless Pre-mRNA,
- Translation,
- PKB-mediated events,
- ISG15 antiviral mechanism,
- Insulin receptor recycling,
- Processing of Intronless Pre-mRNAs,
- mRNA Processing,
- Regulation of AMPK activity via LKB1,
- Cytokine Signaling in Immune system,
- IRS-mediated signalling,
- Formation of RNA Pol II elongation complex,
- Insulin receptor mediated signaling,
- Post-Elongation Processing of Intronless pre-mRNA,
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- IGF1R signaling cascade,
- Metabolism of proteins,
- Metabolism of mRNA,
- Insulin signaling pathway,
- Cleavage of Growing Transcript in the Termination Region,
- Processing of Capped Intron-Containing Pre-mRNA
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 45525 | NCBI Entrez Gene identifiers | FBgn0015218 |
| 69740 | BioGRID | FBgn0015218 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
15 Introns
26 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | eIF-4E | none | 1.809635118 | 19067489 | |
| Lipid storage | eIF-4E | none | 0.145067781 | 19067489 | |
| ERK signaling | eIF-4E | ERK activation reduced | weak | 17086199 | |
| Hedgehog signaling | eIF-4E | Increased Hedgehog reporter activity | 4.62 | 16311596 | |
| Cell size and cell-cycle regulation (1) | eIF-4E | none | sp | 16496002 | |
| Combinatorial effect with methyl methanesulphonate (2) | eIF-4E | none | sp | 19543366 | |
| Muscle morphogenesis and function (1) | eIF-4E | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | eIF-4E | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Muscle morphogenesis and function (3) | eIF-4E | Split myofibril | np | 20220848 | |
| Heat nociception (1) | eIF-4E | Developmentally lethal | -1.17 | 21074052 | |
| Heart development and function (1) | eIF-4E | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | eIF-4E | none | 0.469135802469135 | 19520911 | |
| Notch pathway regulation (4) | eIF-4E | Completely lethal (pupal) | sp | 19363474 | |
| Muscle assembly and maintenance | eIF-4E | Muscles spread, myosin filaments striated, actin filaments lack striation | severe | 18359903 | |
| Hh pathway regulation | eIF-4E | none | 0.0735446152314015 | 17903264 | |
| Hh pathway regulation | eIF-4E | none | 0.0880434612253088 | 17903264 | |
| Self-renewal and differentiation in neural stem cells | eIF-4E | Neuroblast smaller cell size, neuroblast less large cells, ganglion mother cell smaller cell size, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with smaller neuroblast cell size, neuroblasts smaller, neuroblast underproliferatio | sp | 21549331 | |
| Adiposity regulation (1) | eIF-4E | none | -0.601 | 20074523 | |
| S2 cell spreading | eIF-4E | none | np | 21041442 | |
| RTK-Ras-ERK pathway regulation (1) | eIF-4E | Decreased ERK phosphorylation after EGF stimulation | -2.32 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | eIF-4E | Decreased ERK phosphorylation after EGF stimulation | -6.32 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4E | Decreased ERK phosphorylation after sSpitz and EGF stimulation | -1.64 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4E | none | -1.3 | 30 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | eIF-4E | none | -1.18 | 23263283 | |
| Glycosylation regulation (1) | eIF-4E | Decreased (GlcNAc)n Chp glycosylation | sp | 21203496 | |
| Glycosylation regulation (2) | eIF-4E | Effect on Chp glycosylation | np | 21203496 |
