Genomics
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45 Alleles
157 Clones
13 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0015218:9 | eIF-4E:9 |
| FBgn0015218:8 | eIF-4E:8 |
| FBgn0015218:13 | eIF-4E:13 |
| FBgn0015218:11 | eIF-4E:11 |
| FBgn0015218:10 | eIF-4E:10 |
| FBgn0015218:5 | eIF-4E:5 |
| FBgn0015218:4 | eIF-4E:4 |
| FBgn0015218:3 | eIF-4E:3 |
| FBgn0015218:2 | eIF-4E:2 |
| FBgn0015218:1 | eIF-4E:1 |
| FBgn0015218:6 | eIF-4E:6 |
| FBgn0015218:7 | eIF-4E:7 |
| FBgn0015218:12 | eIF-4E:12 |
18 UTRs
Other
71 Pathways
- Insulin receptor recycling,
- Deadenylation of mRNA,
- RNA Polymerase II Transcription Initiation,
- Cap-dependent Translation Initiation,
- DINR-mediated activation,
- PKB-mediated events,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- Transport of Mature Transcript to Cytoplasm,
- Formation of RNA Pol II elongation complex,
- Energy dependent regulation of mTOR by LKB1-AMPK,
- Insulin receptor mediated signaling,
- mTORC1-mediated signalling,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- Elongation arrest and recovery,
- IRS-related events,
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- Processing of Intronless Pre-mRNAs,
- Regulation of AMPK activity via LKB1,
- Formation of a pool of free 40S subunits,
- Metabolism of RNA,
- RNA Pol II CTD phosphorylation and interaction with CE,
- RNA Polymerase II Transcription Elongation,
- Gene Expression,
- Translation,
- Eukaryotic Translation Initiation,
- Release of eIF4E,
- Translation initiation complex formation,
- RNA Polymerase II Promoter Escape,
- Transport of the SLBP independent Mature mRNA,
- PI3K Cascade,
- Post-Elongation Processing of Intronless pre-mRNA,
- mRNA Processing,
- 3' -UTR-mediated translational regulation,
- Deadenylation-dependent mRNA decay,
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- IRS-related events triggered by IGF1R,
- Processing of Capped Intronless Pre-mRNA,
- Insulin receptor signalling cascade,
- RNA Polymerase II Transcription Termination,
- RNA Polymerase II Pre-transcription Events,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- mRNA Capping,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- SLBP independent Processing of Histone Pre-mRNAs,
- Interferon Signaling,
- IRS activation,
- Signaling Pathways,
- Processing of Capped Intron-Containing Pre-mRNA,
- ISG15 antiviral mechanism,
- Metabolism of proteins,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- Cytokine Signaling in Immune system,
- Transcription,
- Insulin signaling pathway,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- RNA Polymerase II Transcription,
- IGF1R signaling cascade,
- Transport of the SLBP Dependant Mature mRNA,
- Formation of the Early Elongation Complex,
- Metabolism of mRNA,
- IRS-mediated signalling,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- Ribosomal scanning and start codon recognition,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- Antiviral mechanism by IFN-stimulated genes,
- Post-Elongation Processing of the Transcript,
- TOR signaling pathway,
- Immune System,
- Regulation of Rheb GTPase activity by AMPK,
- Cleavage of Growing Transcript in the Termination Region,
- mTOR signalling
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 45525 | NCBI Entrez Gene identifiers | FBgn0015218 |
| 69740 | BioGRID | FBgn0015218 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
15 Introns
26 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | eIF-4E | none | 1.809635118 | 19067489 | |
| Lipid storage | eIF-4E | none | 0.145067781 | 19067489 | |
| ERK signaling | eIF-4E | ERK activation reduced | weak | 17086199 | |
| Hedgehog signaling | eIF-4E | Increased Hedgehog reporter activity | 4.62 | 16311596 | |
| Cell size and cell-cycle regulation (1) | eIF-4E | none | sp | 16496002 | |
| Combinatorial effect with methyl methanesulphonate (2) | eIF-4E | none | sp | 19543366 | |
| Muscle morphogenesis and function (1) | eIF-4E | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | eIF-4E | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Muscle morphogenesis and function (3) | eIF-4E | Split myofibril | np | 20220848 | |
| Heat nociception (1) | eIF-4E | Developmentally lethal | -1.17 | 21074052 | |
| Heart development and function (1) | eIF-4E | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | eIF-4E | none | 0.469135802469135 | 19520911 | |
| Notch pathway regulation (4) | eIF-4E | Completely lethal (pupal) | sp | 19363474 | |
| Muscle assembly and maintenance | eIF-4E | Muscles spread, myosin filaments striated, actin filaments lack striation | severe | 18359903 | |
| Hh pathway regulation | eIF-4E | none | 0.0735446152314015 | 17903264 | |
| Hh pathway regulation | eIF-4E | none | 0.0880434612253088 | 17903264 | |
| Self-renewal and differentiation in neural stem cells | eIF-4E | Neuroblast smaller cell size, neuroblast less large cells, ganglion mother cell smaller cell size, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with smaller neuroblast cell size, neuroblasts smaller, neuroblast underproliferatio | sp | 21549331 | |
| Adiposity regulation (1) | eIF-4E | none | -0.601 | 20074523 | |
| S2 cell spreading | eIF-4E | none | np | 21041442 | |
| RTK-Ras-ERK pathway regulation (1) | eIF-4E | Decreased ERK phosphorylation after EGF stimulation | -2.32 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | eIF-4E | Decreased ERK phosphorylation after EGF stimulation | -6.32 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4E | Decreased ERK phosphorylation after sSpitz and EGF stimulation | -1.64 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4E | none | -1.3 | 30 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | eIF-4E | none | -1.18 | 23263283 | |
| Glycosylation regulation (1) | eIF-4E | Decreased (GlcNAc)n Chp glycosylation | sp | 21203496 | |
| Glycosylation regulation (2) | eIF-4E | Effect on Chp glycosylation | np | 21203496 |
