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Gene : eIF-4E D. melanogaster

DB identifier  ? FBgn0015218 Secondary Identifier  ? CG4035
Name  ? Eukaryotic initiation factor 4E Source  FlyBase
  • synonyms:
  • eIF-4E1,
  • 0919/12,
  • eIF4E-1,2,
  • IF4E,
  • l(3)S058711,
  • eIF-4E2,
  • cap binding protein,
  • eIF-4EII,
  • lethal(3)67Af,
  • CG4035,
  • eIF-4e,
  • l(3)07238,
  • FBgn0002202,
  • FBgn0013947,
  • CT39426,
  • l(3)67Af,
  • eIF4E-2,
  • FBgn0010921,
  • FBgn0028178,
  • eukaryotic initiation factor 4E,
  • CT13384,
  • 0589/11,
  • FBgn0015218,
  • eIF 4E,
  • Eukaryotic translation initiation factor 4E,
  • EIF4E,
  • eIF4E-1,
  • l(3)S091912,
  • deIF-4E,
  • eIF-4E1,2,
  • 0260/09,
  • FBan0004035,
  • 7238,
  • eIF4EI,
  • FBgn0060598,
  • CBP,
  • dEif4e,
  • FBgn0061015,
  • l(3)S025007,
  • 0587/11,
  • 1004/13,
  • D-eIF4E,
  • FBgn0035984,
  • eIF4E-1/2,
  • FBgn0060792,
  • CT39424,
  • eIF4E1,
  • l(3)S026009

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45 Alleles

DB identifier Symbol Allele Class Organism
FBal0286419 eIF-4E[Scer\UAS.ORF]   Drosophila melanogaster
FBal0286420 eIF-4E[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0282860 eIF-4E[DOr]   Drosophila melanogaster
FBal0211771 eIF-4E[CC00392]   Drosophila melanogaster
FBal0180059 eIF-4E[d11121]   Drosophila melanogaster
FBal0285969 eIF-4E[YC0001]   Drosophila melanogaster
FBal0175695 eIF-4E[S071513]   Drosophila melanogaster
FBal0129987 eIF-4E[S026009]   Drosophila melanogaster
FBal0129763 eIF-4E[S058711]   Drosophila melanogaster
FBal0129568 eIF-4E[S091912]   Drosophila melanogaster
FBal0180060 eIF-4E[d03437]   Drosophila melanogaster
FBal0180056 eIF-4E[f05739]   Drosophila melanogaster
FBal0180057 eIF-4E[f03004]   Drosophila melanogaster
FBal0180058 eIF-4E[e03130]   Drosophila melanogaster
FBal0257639 eIF-4E[HMS00969]   Drosophila melanogaster
FBal0130400 eIF-4E[EP3371]   Drosophila melanogaster
FBal0009599 eIF-4E[07238]   Drosophila melanogaster
FBal0100128 eIF-4E[S100413]   Drosophila melanogaster
FBal0100129 eIF-4E[S099905]   Drosophila melanogaster
FBal0100130 eIF-4E[S025007]   Drosophila melanogaster
FBal0122994 eIF-4E[EP568]   Drosophila melanogaster
FBal0120511 eIF-4E[S058911]   Drosophila melanogaster
FBal0122992 eIF-4E[Scim-b]   Drosophila melanogaster
FBal0122993 eIF-4E[Scim-a] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0249351 eIF-4E[VDRC.cUa]   Drosophila melanogaster
FBal0175692 eIF-4E[Ser251Asp.t8.9]   Drosophila melanogaster
FBal0175693 eIF-4E[Ser251Ala.t8.9]   Drosophila melanogaster
FBal0175694 eIF-4E[S251D]   Drosophila melanogaster
FBal0175697 eIF-4E[+t8.9]   Drosophila melanogaster
FBal0175696 eIF-4E[2188]   Drosophila melanogaster

157 Clones

Secondary Identifier DB identifier
DPiM_RE36735 FBcl0741975
ESG018b.E21_B06 FBcl0000938
ESG018a.E21_E02 FBcl0003813
ESG0114c.B21_D08 FBcl0007347
ESG013d.E21_C07 FBcl0010493
AT17353 FBcl0037903
EC23774 FBcl0071499
EC30074 FBcl0071507
EC34274 FBcl0071509
EC40287 FBcl0071529
EP04523 FBcl0087161
EN03840 FBcl0100479
EN08437 FBcl0100483
EK303112 FBcl0101590
EK254045 FBcl0101602
EK287822 FBcl0101652
EK126725 FBcl0103596
EK123327 FBcl0103600
EK246659 FBcl0103602
EK065145 FBcl0103642
EK270336 FBcl0103714
EK194258 FBcl0103718
EK259449 FBcl0103720
EK142841 FBcl0103746
EK308737 FBcl0103750
EK276643 FBcl0103756
EK170107 FBcl0103762
EK280702 FBcl0103766
EK295432 FBcl0103770
EK141118 FBcl0103784

13 Exons

DB identifier Symbol
FBgn0015218:9 eIF-4E:9
FBgn0015218:8 eIF-4E:8
FBgn0015218:13 eIF-4E:13
FBgn0015218:11 eIF-4E:11
FBgn0015218:10 eIF-4E:10
FBgn0015218:5 eIF-4E:5
FBgn0015218:4 eIF-4E:4
FBgn0015218:3 eIF-4E:3
FBgn0015218:2 eIF-4E:2
FBgn0015218:1 eIF-4E:1
FBgn0015218:6 eIF-4E:6
FBgn0015218:7 eIF-4E:7
FBgn0015218:12 eIF-4E:12

9 Transcripts

DB identifier Gene
FBtr0076490 eIF-4E
FBtr0076492 eIF-4E
FBtr0076493 eIF-4E
FBtr0076489 eIF-4E
FBtr0076488 eIF-4E
FBtr0076487 eIF-4E
FBtr0076491 eIF-4E
FBtr0333884 eIF-4E
FBtr0333885 eIF-4E

18 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0076490-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0076491-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0076492-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0076493-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0076487-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0076488-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0076489-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0333884-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0333885-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0076490-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0076491-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0076492-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0076493-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0076487-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0076488-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0076489-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0333884-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0333885-3-prime-utr Drosophila melanogaster

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71 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
45525 NCBI Entrez Gene identifiers FBgn0015218
69740 BioGRID FBgn0015218

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 4418.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 4942.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 4334.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 4574.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 4016.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 3046.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 3068.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 4163.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 2398.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 5011.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 4580.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 3793.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 3750.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 4050.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 7290.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 4685.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 6572.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 3187.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 5340.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 4254.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 5179.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 4571.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 3879.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 4177.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 3087.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 10478.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 4058.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 2515.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 3128.0
FBgn0015218 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 4444.0

15 Introns

DB identifier
Organism . Name
intron_FBgn0015218:10_FBgn0015218:5 Drosophila melanogaster
intron_FBgn0015218:5_FBgn0015218:4 Drosophila melanogaster
intron_FBgn0015218:4_FBgn0015218:3 Drosophila melanogaster
intron_FBgn0015218:3_FBgn0015218:2 Drosophila melanogaster
intron_FBgn0015218:2_FBgn0015218:1 Drosophila melanogaster
intron_FBgn0015218:13_FBgn0015218:4 Drosophila melanogaster
intron_FBgn0015218:9_FBgn0015218:5 Drosophila melanogaster
intron_FBgn0015218:8_FBgn0015218:5 Drosophila melanogaster
intron_FBgn0015218:13_FBgn0015218:5 Drosophila melanogaster
intron_FBgn0015218:11_FBgn0015218:5 Drosophila melanogaster
intron_FBgn0015218:10_FBgn0015218:7 Drosophila melanogaster
intron_FBgn0015218:7_FBgn0015218:5 Drosophila melanogaster
intron_FBgn0015218:13_FBgn0015218:6 Drosophila melanogaster
intron_FBgn0015218:6_FBgn0015218:4 Drosophila melanogaster
intron_FBgn0015218:12_FBgn0015218:6 Drosophila melanogaster

26 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage eIF-4E none 1.809635118   19067489
Lipid storage eIF-4E none 0.145067781   19067489
ERK signaling eIF-4E ERK activation reduced weak   17086199
Hedgehog signaling eIF-4E Increased Hedgehog reporter activity 4.62   16311596
Cell size and cell-cycle regulation (1) eIF-4E none sp   16496002
Combinatorial effect with methyl methanesulphonate (2) eIF-4E none sp   19543366
Muscle morphogenesis and function (1) eIF-4E Lethal np   20220848
Muscle morphogenesis and function (2) eIF-4E Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Muscle morphogenesis and function (3) eIF-4E Split myofibril np   20220848
Heat nociception (1) eIF-4E Developmentally lethal -1.17   21074052
Heart development and function (1) eIF-4E none 1   20371351
Serratia marcescens infection (1) eIF-4E none 0.469135802469135   19520911
Notch pathway regulation (4) eIF-4E Completely lethal (pupal) sp   19363474
Muscle assembly and maintenance eIF-4E Muscles spread, myosin filaments striated, actin filaments lack striation severe   18359903
Hh pathway regulation eIF-4E none 0.0735446152314015   17903264
Hh pathway regulation eIF-4E none 0.0880434612253088   17903264
Self-renewal and differentiation in neural stem cells eIF-4E Neuroblast smaller cell size, neuroblast less large cells, ganglion mother cell smaller cell size, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with smaller neuroblast cell size, neuroblasts smaller, neuroblast underproliferatio sp   21549331
Adiposity regulation (1) eIF-4E none -0.601   20074523
S2 cell spreading eIF-4E none np   21041442
RTK-Ras-ERK pathway regulation (1) eIF-4E Decreased ERK phosphorylation after EGF stimulation -2.32 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) eIF-4E Decreased ERK phosphorylation after EGF stimulation -6.32 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) eIF-4E Decreased ERK phosphorylation after sSpitz and EGF stimulation -1.64 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) eIF-4E none -1.3 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation eIF-4E none -1.18   23263283
Glycosylation regulation (1) eIF-4E Decreased (GlcNAc)n Chp glycosylation sp   21203496
Glycosylation regulation (2) eIF-4E Effect on Chp glycosylation np   21203496

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