Genomics
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7 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0159290 | eIF-3p66[EY05735] | Drosophila melanogaster | |
| FBal0270352 | eIF-3p66[NIG.10161R] | Drosophila melanogaster | |
| FBal0095869 | eIF-3p66[GS3028] | Drosophila melanogaster | |
| FBal0287357 | eIF-3p66[Scer\UAS.ORF] | Drosophila melanogaster | |
| FBal0287358 | eIF-3p66[Scer\UAS.ORF.T:Ivir\HA1] | Drosophila melanogaster | |
| FBal0214938 | eIF-3p66[GD6702] | Drosophila melanogaster | |
| FBal0288060 | eIF-3p66[EP-654a] | Drosophila melanogaster |
204 Clones
4 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0040227:1 | eIF-3p66:1 |
| FBgn0040227:2 | eIF-3p66:2 |
| FBgn0040227:3 | eIF-3p66:3 |
| FBgn0040227:4 | eIF-3p66:4 |
2 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0089622-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0089622-3-prime-utr | Drosophila melanogaster |
Other
43 Pathways
- Processing of Capped Intron-Containing Pre-mRNA,
- Processing of Intronless Pre-mRNAs,
- RNA Polymerase II Transcription Elongation,
- Transport of the SLBP Dependant Mature mRNA,
- Elongation arrest and recovery,
- RNA Polymerase II Pre-transcription Events,
- RNA Pol II CTD phosphorylation and interaction with CE,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- Ribosomal scanning and start codon recognition,
- Post-Elongation Processing of the Transcript,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- Formation of a pool of free 40S subunits,
- Gene Expression,
- RNA Polymerase II Transcription,
- mRNA Processing,
- Cleavage of Growing Transcript in the Termination Region,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- Post-Elongation Processing of Intronless pre-mRNA,
- Formation of RNA Pol II elongation complex,
- Transport of the SLBP independent Mature mRNA,
- Eukaryotic Translation Initiation,
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- Transport of Mature Transcript to Cytoplasm,
- Formation of the Early Elongation Complex,
- Transcription,
- RNA Polymerase II Transcription Initiation,
- Translation,
- RNA Polymerase II Promoter Escape,
- Recycling of eIF2:GDP,
- Processing of Capped Intronless Pre-mRNA,
- 3' -UTR-mediated translational regulation,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- Translation initiation complex formation,
- Formation of the ternary complex, and subsequently, the 43S complex,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- mRNA Capping,
- Cap-dependent Translation Initiation,
- SLBP independent Processing of Histone Pre-mRNAs,
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- Metabolism of proteins,
- RNA Polymerase II Transcription Termination
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 42789 | NCBI Entrez Gene identifiers | FBgn0040227 |
| 67727 | BioGRID | FBgn0040227 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
23 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | eIF-3p66 | none | 0.057542597 | 19067489 | |
| Lipid storage | eIF-3p66 | none | -0.629391353 | 19067489 | |
| Cytokinesis regulation | eIF-3p66 | Binucleate cells | weak | 15547975 | |
| Cell size and cell-cycle regulation (1) | eIF-3p66 | Increased G1 DNA content, increased G1 cell size | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | eIF-3p66 | Increased G1 DNA content, increased G1 cell size | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | eIF-3p66 | none | 0.963 | 16496002 | |
| Cell size and cell-cycle regulation (2) | eIF-3p66 | none | 1.337 | 16496002 | |
| Cell size and cell-cycle regulation (3) | eIF-3p66 | Decreased cell number | 413 | 16496002 | |
| Cell size and cell-cycle regulation (3) | eIF-3p66 | none | 423 | 16496002 | |
| C. trachomatis infection | eIF-3p66 | C. trachomatis infection up | np | 18369471 | |
| Influenza replication | eIF-3p66 | Decreased Influenza replication | -1.61/-2.83 | 18615016 | |
| Mitochondrial biogenesis and function | eIF-3p66 | Increased mitochondrial citrate synthase activity, decreased viability | 2.016 | 18042644 | |
| Microtubule assembly and organization | eIF-3p66 | none | np | 18463163 | |
| Mutant human huntingtin aggregation | eIF-3p66 | Decreased mutant human huntingtin aggregation | <= -2 | 19789644 | |
| Notch pathway regulation (1) | eIF-3p66 | Downregulation of Notch pathway | np | 20493818 | |
| Notch pathway regulation (2) | eIF-3p66 | none | np | en-GAL4 | 20493818 |
| Notch pathway regulation (3) | eIF-3p66 | Only lethal with Notch | np | 20493818 | |
| RTK-Ras-ERK pathway regulation (1) | eIF-3p66 | Increased ERK phosphorylation after EGF stimulation | 1.51 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | eIF-3p66 | none | -0.37 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-3p66 | Increased ERK phosphorylation after sSpitz and EGF stimulation | 1.53 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-3p66 | Increased ERK phosphorylation after sSpitz and EGF stimulation | 3.98 | 30 minutes sSpitz stimulation | 22028469 |
| Hippo pathway regulation | eIF-3p66 | none | -1.23 | 23263283 | |
| Glycosylation regulation (1) | eIF-3p66 | none | sp | 21203496 |
