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Gene : cdc2 D. melanogaster

DB identifier  ? FBgn0004106 Secondary Identifier  ? CG5363
Name  ? cdc2 Source  FlyBase
  • synonyms:
  • CDC2,
  • 5363,
  • FBgn0004106,
  • protein 2,
  • Dm cdc2,
  • DmCdk1,
  • Cell division control,
  • group 4,
  • FBan0005363,
  • CDCDm,
  • Cdk-1,
  • cdc,
  • l(2)31Eh,
  • cyclin-dependent kinase,
  • cyclin dependent kinase,
  • cyclin-dependent kinase 1,
  • dCdk1,
  • CDC2 kinase,
  • Dcdc2,
  • CDK1/CDC2,
  • CDK1,
  • DmCdc2,
  • CG5363,
  • cdc2Dm

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36 Alleles

DB identifier Symbol Allele Class Organism
FBal0195544 cdc2[2]   Drosophila melanogaster
FBal0195545 cdc2[3]   Drosophila melanogaster
FBal0159417 cdc2[GT-000294]   Drosophila melanogaster
FBal0159416 cdc2[c03495]   Drosophila melanogaster
FBal0286510 cdc2[Scer\UAS.ORF]   Drosophila melanogaster
FBal0286511 cdc2[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0030730 cdc2[216P] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0001574 cdc2[E1-24] heat sensitive loss of function allele Drosophila melanogaster
FBal0001572 cdc2[D57] amorphic allele - genetic evidence Drosophila melanogaster
FBal0034324 cdc2[+t5.8]   Drosophila melanogaster
FBal0030733 cdc2[hs.PS]   Drosophila melanogaster
FBal0045439 cdc2[A171T]   Drosophila melanogaster
FBal0062926 cdc2[E1-4] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0060474 cdc2[P131S]   Drosophila melanogaster
FBal0060475 cdc2[G43E]   Drosophila melanogaster
FBal0060476 cdc2[G177E]   Drosophila melanogaster
FBal0030732 cdc2[E10] amorphic allele - genetic evidence Drosophila melanogaster
FBal0064930 cdc2[AF.hs]   Drosophila melanogaster
FBal0001575 cdc2[E1-9] amorphic allele - genetic evidence Drosophila melanogaster
FBal0001573 cdc2[E1-23] amorphic allele - genetic evidence Drosophila melanogaster
FBal0030731 cdc2[B47] loss of function allele, amorphic allele - genetic evidence Drosophila melanogaster
FBal0001571 cdc2[216A] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0089420 cdc2[unspecified]   Drosophila melanogaster
FBal0121834 cdc2[E51Q]   Drosophila melanogaster
FBal0262732 cdc2[GL00262]   Drosophila melanogaster
FBal0121835 cdc2[E51Q.Scer\UAS]   Drosophila melanogaster
FBal0121833 cdc2[K33R.T161A.Scer\UAS]   Drosophila melanogaster
FBal0097040 cdc2[Scer\UAS.cHa]   Drosophila melanogaster
FBal0065868 cdc2[Scer\UAS.cWa]   Drosophila melanogaster
FBal0118304 cdc2[Scer\UAS.T:Hsap\MYC]   Drosophila melanogaster

46 Clones

Secondary Identifier DB identifier
DPiM_LD38718 FBcl0741082
CK02479 FBcl0060253
EK249264 FBcl0098612
EK056806 FBcl0098698
EK055210 FBcl0098704
EK056247 FBcl0098708
EK221951 FBcl0098750
EK257713 FBcl0098754
LD10840 FBcl0162546
LD07161 FBcl0162554
LD45355 FBcl0171083
LD38718 FBcl0178436
LD31547 FBcl0178440
LD26702 FBcl0178445
LD31004 FBcl0178449
RE47569 FBcl0237878
RE03688 FBcl0237880
RE58009 FBcl0237885
RE33541 FBcl0237890
RE08819 FBcl0237912
RE03445 FBcl0237914
RE73468 FBcl0237915
RE69930 FBcl0237916
RE71275 FBcl0237924
RE10846 FBcl0237931
RE52268 FBcl0237933
RE55767 FBcl0237938
RE52532 FBcl0237958
RE36090 FBcl0238589
RE66482 FBcl0238590

3 Exons

DB identifier Symbol
FBgn0004106:1 cdc2:1
FBgn0004106:3 cdc2:3
FBgn0004106:2 cdc2:2

1 Transcripts

DB identifier Gene
FBtr0080051 cdc2

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0080051-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0080051-3-prime-utr Drosophila melanogaster

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139 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
34411 NCBI Entrez Gene identifiers FBgn0004106
60495 BioGRID FBgn0004106

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1231.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1238.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 1117.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 942.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1049.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 632.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 552.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 666.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 380.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1362.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 938.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 881.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 846.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 749.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1082.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 1011.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1012.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 916.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1525.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1026.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 922.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1461.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 952.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 709.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 1029.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 4245.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 3907.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 3732.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 3253.0
FBgn0004106 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 2350.0

2 Introns

DB identifier
Organism . Name
intron_FBgn0004106:3_FBgn0004106:2 Drosophila melanogaster
intron_FBgn0004106:2_FBgn0004106:1 Drosophila melanogaster

48 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage cdc2 none -1.624448355   19067489
Lipid storage cdc2 none 0.138448795   19067489
Chlamydia caviae infection cdc2 Decreased Chlamydia caviae infection np   17967059
ERK signaling cdc2 ERK activation reduced strong   17086199
Drosophila C virus infection cdc2 Drosophila C virus replication down np   17040126
Cell morphology cdc2 Morphology np   14527345
Cell cycle regulation (1) cdc2 Increased G2/M DNA content, increased cell size, decreased cytokinetic index, increased number of cells in prometaphase and metaphase, chromosome defects sp   15616552
Cell cycle regulation (2) cdc2 Increased G2/M DNA content, increased cell size np   15616552
Cytokinesis regulation cdc2 Binucleate cells with decreased viability weak   15547975
Intracellular Listeria monocytogenes infection cdc2 Increased GFP protein expression moderate   16020693
Wnt signaling cdc2 Decreased Wnt reporter activity -0.88   15817814
Constitutive protein secretion and Golgi organization (1) cdc2 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) cdc2 Decreased G1 DNA content, increased G2 DNA content sp   16496002
Cell size and cell-cycle regulation (1) cdc2 none sp   16496002
Cell size and cell-cycle regulation (1) cdc2 Decreased G1 DNA content, decreased viability sp   16496002
Cell size and cell-cycle regulation (2) cdc2 none 1.095   16496002
Cell size and cell-cycle regulation (3) cdc2 none 429   16496002
Cell size and cell-cycle regulation (4) cdc2 none below threshold   16496002
Influenza replication cdc2 Decreased Influenza replication -2.1/-3.36   18615016
Mitochondrial biogenesis and function cdc2 Increased mitochondrial citrate synthase activity 2.003   18042644
Lipid storage cdc2 Fewer lipid droplets strong   18408709
Combinatorial effect with methyl methanesulphonate (1) cdc2 none sp   19543366
Combinatorial effect with methyl methanesulphonate (2) cdc2 none sp   19543366
Mutant human huntingtin aggregation cdc2 Decreased mutant human huntingtin aggregation <= -2   19789644
Muscle morphogenesis and function (1) cdc2 Lethal np   20220848
Muscle morphogenesis and function (1) cdc2 none np   20220848
Muscle morphogenesis and function (2) cdc2 Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Heat nociception (1) cdc2 Developmentally lethal 0   21074052
Heart development and function (1) cdc2 none 1   20371351
Serratia marcescens infection (1) cdc2 none 0.465116279069767   19520911

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