Genomics
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21 Alleles
117 Clones
7 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0020497:3 | emb:3 |
| FBgn0020497:4 | emb:4 |
| FBgn0020497:5 | emb:5 |
| FBgn0020497:6 | emb:6 |
| FBgn0020497:7 | emb:7 |
| FBgn0020497:1 | emb:1 |
| FBgn0020497:2 | emb:2 |
2 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0079663-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0079663-3-prime-utr | Drosophila melanogaster |
Other
39 Pathways
- Disease,
- Double-Strand Break Repair,
- Cell Cycle Checkpoints,
- Mitotic M-M/G1 phases,
- Signaling by TGF-beta Receptor Complex,
- Loss of Function of SMAD2/3 in Cancer,
- Loss of Function of TGFBR2 in Cancer,
- SMAD2/3 MH2 Domain Mutants in Cancer,
- Signaling by TGF-beta Receptor Complex in Cancer,
- Homologous recombination repair of replication-independent double-strand breaks,
- TGFBR2 MSI Frameshift Mutants in Cancer,
- DNA Repair,
- G1/S DNA Damage Checkpoints,
- SMAD4 MH2 Domain Mutants in Cancer,
- TGFBR1 KD Mutants in Cancer,
- G2/M DNA replication checkpoint,
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex,
- TGF-beta receptor signaling activates SMADs,
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A,
- G2/M DNA damage checkpoint,
- TGFBR2 Kinase Domain Mutants in Cancer,
- SMAD2/3 Phosphorylation Motif Mutants in Cancer,
- Homologous Recombination Repair,
- TGFBR1 LBD Mutants in Cancer,
- G2/M Transition,
- Loss of Function of TGFBR1 in Cancer,
- p53-Independent DNA Damage Response,
- ATM mediated response to DNA double-strand break,
- Cell Cycle, Mitotic,
- p53-Independent G1/S DNA damage checkpoint,
- Loss of Function of SMAD4 in Cancer,
- Cell Cycle,
- Downregulation of TGF-beta receptor signaling,
- G2/M Checkpoints,
- DNA Replication,
- Mitotic G2-G2/M phases,
- Cyclin A/B1 associated events during G2/M transition,
- Signaling Pathways,
- Mitotic G1-G1/S phases
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 34167 | NCBI Entrez Gene identifiers | FBgn0020497 |
| 60290 | BioGRID | FBgn0020497 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
6 Introns
27 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | emb | none | 0.228515324 | 19067489 | |
| Lipid storage | emb | none | -0.860366364 | 19067489 | |
| ERK signaling | emb | ERK activation increased | weak | 17086199 | |
| Wnt signaling | emb | Increased Wnt reporter activity | 4.3 | 15817814 | |
| Cell size and cell-cycle regulation (1) | emb | Decreased G1 DNA content | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | emb | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | emb | none | 1.356 | 16496002 | |
| Cell size and cell-cycle regulation (3) | emb | Decreased cell number | 416 | 16496002 | |
| Cell size and cell-cycle regulation (4) | emb | Increased number of mitotic cells | 0.8 | 16496002 | |
| Centriole duplication and centrosome maturation | emb | Centriole duplication defect | np | 18798690 | |
| Muscle morphogenesis and function (1) | emb | Lethal | np | 20220848 | |
| Heart development and function (1) | emb | none | 1 | 20371351 | |
| Notch pathway regulation (4) | emb | none | 0 | 19363474 | |
| Notch induced transcription | emb | none | 2.3157 | without Notch stimulation | 20959007 |
| Notch induced transcription | emb | none | 1.1879 | N(delta)ecn Notch stimulation | 20959007 |
| Notch induced transcription | emb | Downregulation of Notch pathway after Notch stimulation | -2.0014 | N(delta)ecn Notch stimulation | 20959007 |
| Notch pathway regulation (1) | emb | Downregulation of Notch pathway | np | 20493818 | |
| Notch pathway regulation (2) | emb | none | np | en-GAL4 | 20493818 |
| Notch pathway regulation (3) | emb | none | np | 20493818 | |
| RTK-Ras-ERK pathway regulation (1) | emb | none | 0.32 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | emb | none | -0.86 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | emb | none | -0.28 | 10 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | emb | none | 0.34 | 30 minutes sSpitz stimulation | 22028469 |
| Wnt proteins secretion | emb | none | 4.2 | 22094269 | |
| Wg pathway regulation (1) | emb | Decreased WgRluc and not changed sFluc protein expression | strong | 21886182 | |
| Hippo pathway regulation | emb | none | 1.88 | 23263283 | |
| Glycosylation regulation (1) | emb | none | sp | 21203496 |
