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Gene : rl D. melanogaster

DB identifier  ? FBgn0003256 Secondary Identifier  ? CG12559
Name  ? rolled Source  FlyBase
  • synonyms:
  • DERK-A,
  • DmMAPK,
  • mitogen-activated protein kinase,
  • dp-ERK,
  • CG18732,
  • FBgn0042217,
  • Extracellular-signal-related kinase A,
  • Erk1,
  • CG12559,
  • pMAPK,
  • E(sina)7,
  • extracellular signal-regulated kinase A,
  • DpERK,
  • Su(Raf)2B,
  • Erk/Map kinase,
  • MAP-kinase,
  • pERK,
  • Enhancer of seven in absentia 7,
  • ERK,
  • GroupII,
  • dm-dpERK,
  • Extracellular-regulated kinase A,
  • D-ERK,
  • rl/MAPK,
  • Erk MAP kinase,
  • Drosophila ERK,
  • Rl,
  • l(2)41Ac,
  • FBgn0047177,
  • dpERK1,
  • ERK/rolled,
  • ERK-A,
  • SR2-1,
  • BcDNA:RE08694,
  • DmERK-A,
  • l(2R)EMS45-39,
  • FBgn0039983,
  • FBgn0003256,
  • MAP-k,
  • phospho-ERK,
  • 12559,
  • FBgn0005693,
  • roll,
  • SEM,
  • CT34260,
  • EY2-2,
  • MAP kinase,
  • MAPK,
  • dpMAPK,
  • rl/ERK,
  • Diphospho-ERK,
  • EK2-1,
  • extracellular signal-regulated kinase,
  • rll,
  • Sevenmaker,
  • Dsor2,
  • DERK,
  • DmERKA,
  • FBan0012559,
  • Rolled,
  • CT39192,
  • DmErk,
  • mitogen activated protein kinase,
  • ERKA

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109 Alleles

DB identifier Symbol Allele Class Organism
FBal0281863 rl[MI07033]   Drosophila melanogaster
FBal0282716 rl[Scer\UAS.cMa]   Drosophila melanogaster
FBal0282717 rl[E335K.Scer\UAS]   Drosophila melanogaster
FBal0245402 rl[JF01080]   Drosophila melanogaster
FBal0245648 rl[JF01366]   Drosophila melanogaster
FBal0276790 rl[sem.cUa.Scer\UAS]   Drosophila melanogaster
FBal0241100 rl[GD4697]   Drosophila melanogaster
FBal0151609 rl[47.122.1]   Drosophila melanogaster
FBal0260126 rl[KK115768]   Drosophila melanogaster
FBal0063803 rl[IR1]   Drosophila melanogaster
FBal0039840 rl[R26] amorphic allele - genetic evidence Drosophila melanogaster
FBal0063799 rl[IR41]   Drosophila melanogaster
FBal0063802 rl[IR27]   Drosophila melanogaster
FBal0044318 rl[X16z]   Drosophila melanogaster
FBal0063800 rl[IR37]   Drosophila melanogaster
FBal0050336 rl[8M4]   Drosophila melanogaster
FBal0035510 rl[D334N.hs.sev]   Drosophila melanogaster
FBal0035512 rl[K67M:D334N.hs.sev]   Drosophila melanogaster
FBal0035515 rl[hs.sev]   Drosophila melanogaster
FBal0039839 rl[K164.hs]   Drosophila melanogaster
FBal0039842 rl[hs.PB]   Drosophila melanogaster
FBal0050335 rl[6L1]   Drosophila melanogaster
FBal0050339 rl[Sem.sev] gain of function allele Drosophila melanogaster
FBal0051217 rl[Sem.hs.sev]   Drosophila melanogaster
FBal0014596 rl[10]   Drosophila melanogaster
FBal0035513 rl[Sem.Act5C.P]   Drosophila melanogaster
FBal0014597 rl[G]   Drosophila melanogaster
FBal0118067 rl[C18]   Drosophila melanogaster
FBal0039841 rl[R29] amorphic allele - genetic evidence Drosophila melanogaster
FBal0039836 rl[2L1] amorphic allele - genetic evidence Drosophila melanogaster

38 Clones

Secondary Identifier DB identifier
DPiM_RE08694 FBcl0740974
EK259058 FBcl0030838
EK261053 FBcl0031240
HL04246 FBcl0150427
FI18226 FBcl0743439
RE08694 FBcl0360187
IP08651 FBcl0360222
Dmel_dig_002983_0710_0529 FBcl0362962
Dmel_dig_020891_0583_3271 FBcl0362963
RP004251387 FBcl0701113
RP004527266 FBcl0701114
RP001037878 FBcl0701115
RP004533225 FBcl0701116
RP004535505 FBcl0701117
RP004355967 FBcl0701118
RP004111419 FBcl0701119
RP004242760 FBcl0701120
RP004264609 FBcl0701121
RP004261945 FBcl0701122
RP004065573 FBcl0701123
RP001044585 FBcl0701124
RP004253063 FBcl0701125
RP001046838 FBcl0701126
RP004210047 FBcl0701127
RP004536883 FBcl0701128
RP001046323 FBcl0701129
RP003497848 FBcl0701130
RP004245038 FBcl0701131
RP004419637 FBcl0701132
RP004204648 FBcl0701133

16 Exons

DB identifier Symbol
FBgn0003256:2 rl:2
FBgn0003256:5 rl:5
FBgn0003256:7 rl:7
FBgn0003256:9 rl:9
FBgn0003256:11 rl:11
FBgn0003256:12 rl:12
FBgn0003256:13 rl:13
FBgn0003256:14 rl:14
FBgn0003256:3 rl:3
FBgn0003256:10 rl:10
FBgn0003256:1 rl:1
FBgn0003256:4 rl:4
FBgn0003256:6 rl:6
FBgn0003256:15 rl:15
FBgn0003256:8 rl:8
FBgn0003256:16 rl:16

6 Transcripts

DB identifier Gene
FBtr0113703 rl
FBtr0329920 rl
FBtr0329919 rl
FBtr0113700 rl
FBtr0113702 rl
FBtr0113701 rl

12 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0113700-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0113701-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0113702-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0113703-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0329919-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0329920-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0113700-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0113701-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0113702-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0113703-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0329919-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0329920-3-prime-utr Drosophila melanogaster

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115 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
3354888 NCBI Entrez Gene identifiers FBgn0003256
78013 BioGRID FBgn0003256

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1632.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1583.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 2922.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1805.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 2379.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1715.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1943.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1409.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1983.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 2541.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1668.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1759.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 2408.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1364.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 2351.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 2284.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1459.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 1812.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 2511.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 2286.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1594.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1526.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1230.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1836.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 3623.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 3650.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 1991.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 908.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1446.0
FBgn0003256 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1469.0

18 Introns

DB identifier
Organism . Name
intron_FBgn0003256:2_FBgn0003256:5 Drosophila melanogaster
intron_FBgn0003256:5_FBgn0003256:7 Drosophila melanogaster
intron_FBgn0003256:7_FBgn0003256:9 Drosophila melanogaster
intron_FBgn0003256:9_FBgn0003256:11 Drosophila melanogaster
intron_FBgn0003256:11_FBgn0003256:12 Drosophila melanogaster
intron_FBgn0003256:12_FBgn0003256:13 Drosophila melanogaster
intron_FBgn0003256:13_FBgn0003256:14 Drosophila melanogaster
intron_FBgn0003256:3_FBgn0003256:7 Drosophila melanogaster
intron_FBgn0003256:7_FBgn0003256:10 Drosophila melanogaster
intron_FBgn0003256:1_FBgn0003256:5 Drosophila melanogaster
intron_FBgn0003256:2_FBgn0003256:4 Drosophila melanogaster
intron_FBgn0003256:4_FBgn0003256:6 Drosophila melanogaster
intron_FBgn0003256:6_FBgn0003256:7 Drosophila melanogaster
intron_FBgn0003256:13_FBgn0003256:15 Drosophila melanogaster
intron_FBgn0003256:4_FBgn0003256:7 Drosophila melanogaster
intron_FBgn0003256:7_FBgn0003256:8 Drosophila melanogaster
intron_FBgn0003256:8_FBgn0003256:9 Drosophila melanogaster
intron_FBgn0003256:13_FBgn0003256:16 Drosophila melanogaster

39 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Cell size regulation rl Decreased cell size -2.8   19216764
Lipid storage rl none -0.109576156   19067489
Lipid storage rl none 0.238725039   19067489
Lipid storage rl none 0.11819402   19067489
Lipid storage rl none -1.711016499   19067489
Neural outgrowth rl Defasciculation np   18604272
Cell cycle regulation (1) rl none np   15616552
Cell cycle regulation (2) rl none np   15616552
Cell size and cell-cycle regulation (1) rl none sp   16496002
Cell size and cell-cycle regulation (1) rl none sp   16496002
Combinatorial effect with methyl methanesulphonate (2) rl Synthetic lethal with methyl methanesulphonate sp   19543366
Muscle morphogenesis and function (1) rl Lethal np   20220848
Muscle morphogenesis and function (1) rl Lethal np   20220848
Muscle morphogenesis and function (1) rl Lethal np   20220848
Muscle morphogenesis and function (1) rl Lethal np   20220848
Muscle morphogenesis and function (1) rl none np   20220848
Heat nociception (1) rl Lethal 0   21074052
Heat nociception (1) rl none 1.31   21074052
Heat nociception (1) rl none 1.65   21074052
Heart development and function (1) rl none 1   20371351
Heart development and function (1) rl none 1   20371351
Notch pathway regulation (4) rl Notum malformation death 7   19363474
Notch pathway regulation (4) rl Bristle morphology defects, notum malformation death sp   19363474
Notch pathway regulation (4) rl Bristle morphology defects, notum malformation death sp   19363474
Notch pathway regulation (4) rl Bristle morphology defects, notum malformation death sp   19363474
PGN-induced dJNK phosphorylation rl Increased P-JNK protein expression with PGN 2.5 15 min PGN induction 19893628
Pol II elongation rl none 75 20 min heat shock 19279664
Actin organization and cell morphology (1) rl none np   19265526
Actin organization and cell morphology (2) rl none np   19265526
Actin organization and cell morphology (3) rl none np   19265526

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