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Gene : Rheb D. melanogaster

DB identifier  ? FBgn0041191 Secondary Identifier  ? CG1081
Name  ? Ras homolog enriched in brain ortholog (H. sapiens) Source  FlyBase
  • synonyms:
  • Ras homology enriched in brain,
  • Ras homolog enriched in brain,
  • CG1081,
  • FBgn0037343,
  • Q9VND8,
  • Dm Rheb,
  • FBgn0041191,
  • dRheb,
  • Ras homologue enriched in brain,
  • DmRheb,
  • RHEB,
  • FBan0001081,
  • DReb

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34 Alleles

DB identifier Symbol Allele Class Organism
FBal0195997 Rheb[t10.8]   Drosophila melanogaster
FBal0258444 Rheb[Scer\UAS.cUa]   Drosophila melanogaster
FBal0181936 Rheb[LA01053]   Drosophila melanogaster
FBal0159901 Rheb[EP50.084]   Drosophila melanogaster
FBal0159902 Rheb[EP50.084-loxP]   Drosophila melanogaster
FBal0257596 Rheb[HMS00923]   Drosophila melanogaster
FBal0181934 Rheb[c02175]   Drosophila melanogaster
FBal0159900 Rheb[EY08085]   Drosophila melanogaster
FBal0152254 Rheb[GSjE2]   Drosophila melanogaster
FBal0141561 Rheb[AV4] loss of function allele Drosophila melanogaster
FBal0246849 Rheb[1.1.Scer\UAS]   Drosophila melanogaster
FBal0159909 Rheb[2G5]   Drosophila melanogaster
FBal0159908 Rheb[3M2]   Drosophila melanogaster
FBal0152250 Rheb[dsRNA.cBa]   Drosophila melanogaster
FBal0159906 Rheb[4L1]   Drosophila melanogaster
FBal0159899 Rheb[unspecified]   Drosophila melanogaster
FBal0159912 Rheb[201]   Drosophila melanogaster
FBal0159905 Rheb[501]   Drosophila melanogaster
FBal0152252 Rheb[PDelta2]   Drosophila melanogaster
FBal0159907 Rheb[44.1]   Drosophila melanogaster
FBal0159904 Rheb[56]   Drosophila melanogaster
FBal0159911 Rheb[26.2]   Drosophila melanogaster
FBal0159910 Rheb[2D1]   Drosophila melanogaster
FBal0159913 Rheb[1TI]   Drosophila melanogaster
FBal0181933 Rheb[dsRNA.cPa]   Drosophila melanogaster
FBal0159903 Rheb[7A1]   Drosophila melanogaster
FBal0152253 Rheb[PDelta1]   Drosophila melanogaster
FBal0197209 Rheb[Act5C.cHa.T:Hsap\MYC]   Drosophila melanogaster
FBal0270620 Rheb[NIG.1081R]   Drosophila melanogaster
FBal0152255 Rheb[Act5C.T:Hsap\MYC]   Drosophila melanogaster

82 Clones

Secondary Identifier DB identifier
EK271839 FBcl0041940
EK106812 FBcl0043720
EK056948 FBcl0045756
EK177207 FBcl0045916
EK143551 FBcl0046048
EK193762 FBcl0046196
EK181611 FBcl0046396
EK107713 FBcl0046466
EK251610 FBcl0046618
EK177614 FBcl0046640
EC14483 FBcl0062305
EC22461 FBcl0062315
EN15458 FBcl0091901
GH01594 FBcl0112129
GH14723 FBcl0112163
GH15143 FBcl0112175
GH10361 FBcl0112319
GH16019 FBcl0112711
GH14625 FBcl0113387
GM12218 FBcl0144345
GM14235 FBcl0144346
LD31416 FBcl0167709
LP06653 FBcl0182889
LP04140 FBcl0182997
LP03973 FBcl0183001
LP08731 FBcl0183109
LP05834 FBcl0183364
LP12055 FBcl0183552
RE59691 FBcl0205503
RE74057 FBcl0205654

7 Exons

DB identifier Symbol
FBgn0041191:2 Rheb:2
FBgn0041191:4 Rheb:4
FBgn0041191:5 Rheb:5
FBgn0041191:6 Rheb:6
FBgn0041191:7 Rheb:7
FBgn0041191:1 Rheb:1
FBgn0041191:3 Rheb:3

2 Transcripts

DB identifier Gene
FBtr0078693 Rheb
FBtr0078694 Rheb

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0078693-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0078694-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0078693-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0078694-3-prime-utr Drosophila melanogaster

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1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
117332 NCBI Entrez Gene identifiers FBgn0041191

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 2369.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 2699.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 2689.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 2992.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 3507.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1482.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 3849.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 2352.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 2731.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 2468.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 2427.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1632.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 3018.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1768.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1934.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 2387.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 2370.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 2029.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 2812.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1883.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 2668.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 2485.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 2163.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 2707.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 1232.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 4679.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2838.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 2103.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 2349.0
FBgn0041191 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 3002.0

6 Introns

DB identifier
Organism . Name
intron_FBgn0041191:2_FBgn0041191:4 Drosophila melanogaster
intron_FBgn0041191:4_FBgn0041191:5 Drosophila melanogaster
intron_FBgn0041191:5_FBgn0041191:6 Drosophila melanogaster
intron_FBgn0041191:6_FBgn0041191:7 Drosophila melanogaster
intron_FBgn0041191:1_FBgn0041191:3 Drosophila melanogaster
intron_FBgn0041191:3_FBgn0041191:4 Drosophila melanogaster

20 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Cell size regulation Rheb Decreased cell size -2.52   19216764
Lipid storage Rheb none 1.777877965   19067489
Lipid storage Rheb none 3.660486112   19067489
Neural outgrowth Rheb Defasciculation np   18604272
ERK signaling Rheb ERK activation increased strong   17086199
Constitutive protein secretion and Golgi organization (1) Rheb Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Rheb none sp   16496002
Mitosis Rheb Chromosome misalignment np   17412918
Combinatorial effect with methyl methanesulphonate (2) Rheb none sp   19543366
Mutant human huntingtin aggregation Rheb Decreased mutant human huntingtin aggregation <= -2   19789644
Akt-TOR pathway negative feedback regulation Rheb Increased dAkt phosphorylation 3.2 without insulin stimulation 20585550
Akt-TOR pathway negative feedback regulation Rheb none 2.1 10 min insulin stimulation 20585550
S2 cell spreading Rheb none np   21041442
RTK-Ras-ERK pathway regulation (1) Rheb none -1.34 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Rheb none 0.37 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Rheb none 0.55 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Rheb none 0.98 10 minutes sSpitz stimulation 22028469
Wg pathway regulation (1) Rheb Decreased WgRluc and not changed sFluc protein expression medium   21886182
Hippo pathway regulation Rheb none 0.62   23263283
Glycosylation regulation (1) Rheb none sp   21203496

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