Genomics
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71 Alleles
907 Clones
11 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0001942:8 | eIF-4a:8 |
| FBgn0001942:2 | eIF-4a:2 |
| FBgn0001942:3 | eIF-4a:3 |
| FBgn0001942:4 | eIF-4a:4 |
| FBgn0001942:5 | eIF-4a:5 |
| FBgn0001942:6 | eIF-4a:6 |
| FBgn0001942:11 | eIF-4a:11 |
| FBgn0001942:1 | eIF-4a:1 |
| FBgn0001942:7 | eIF-4a:7 |
| FBgn0001942:9 | eIF-4a:9 |
| FBgn0001942:10 | eIF-4a:10 |
6 Transcripts
| DB identifier | Gene |
|---|---|
| FBtr0307068 | eIF-4a |
| FBtr0079177 | eIF-4a |
| FBtr0079178 | eIF-4a |
| FBtr0331201 | eIF-4a |
| FBtr0079175 | eIF-4a |
| FBtr0079176 | eIF-4a |
12 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0079175-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0079176-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0079177-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0079178-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0307068-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0331201-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0079175-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0079176-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0079177-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0079178-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0307068-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0331201-3-prime-utr | Drosophila melanogaster |
Other
50 Pathways
- 3' -UTR-mediated translational regulation,
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- RNA Polymerase II Transcription Initiation,
- mRNA Capping,
- RNA Polymerase II Promoter Escape,
- Deadenylation-dependent mRNA decay,
- Processing of Capped Intronless Pre-mRNA,
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- RNA Polymerase II Pre-transcription Events,
- Formation of a pool of free 40S subunits,
- Metabolism of proteins,
- RNA Polymerase II Transcription Termination,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- Metabolism of mRNA,
- Cleavage of Growing Transcript in the Termination Region,
- Eukaryotic Translation Initiation,
- Transcription,
- Elongation arrest and recovery,
- Transport of Mature Transcript to Cytoplasm,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- mRNA Processing,
- RNA Polymerase II Transcription,
- Immune System,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- Processing of Intronless Pre-mRNAs,
- Ribosomal scanning and start codon recognition,
- Post-Elongation Processing of Intronless pre-mRNA,
- Transport of the SLBP Dependant Mature mRNA,
- Gene Expression,
- Formation of the Early Elongation Complex,
- RNA Polymerase II Transcription Elongation,
- Processing of Capped Intron-Containing Pre-mRNA,
- Cytokine Signaling in Immune system,
- Transport of the SLBP independent Mature mRNA,
- Metabolism of RNA,
- Translation initiation complex formation,
- Formation of RNA Pol II elongation complex,
- RNA Pol II CTD phosphorylation and interaction with CE,
- ISG15 antiviral mechanism,
- Cap-dependent Translation Initiation,
- Interferon Signaling,
- Post-Elongation Processing of the Transcript,
- SLBP independent Processing of Histone Pre-mRNAs,
- Antiviral mechanism by IFN-stimulated genes,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- Translation,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- Deadenylation of mRNA
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 33835 | NCBI Entrez Gene identifiers | FBgn0001942 |
| 60000 | BioGRID | FBgn0001942 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
10 Introns
32 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | eIF-4a | Increased lipid droplet area | 3.147166637 | 19067489 | |
| Lipid storage | eIF-4a | Increased lipid droplet area | 4.536100146 | 19067489 | |
| ERK signaling | eIF-4a | ERK activation reduced | weak | 17086199 | |
| Alternative splicing | eIF-4a | Alternative para (exon A/I) splicing | sp | 15492211 | |
| Constitutive protein secretion and Golgi organization (1) | eIF-4a | Decreased horseradish peroxidase protein expression | sp | 16452979 | |
| Cell size and cell-cycle regulation (1) | eIF-4a | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | eIF-4a | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | eIF-4a | Increased G1 DNA content, decreased G2 DNA content, decreased cytokinesis | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | eIF-4a | none | 0.982 | 16496002 | |
| Cell size and cell-cycle regulation (3) | eIF-4a | none | 448 | 16496002 | |
| Influenza replication | eIF-4a | Decreased Influenza replication | -3.08/-2.91 | 18615016 | |
| Lipid storage | eIF-4a | Smaller sized lipid droplets, more dispersed | strong | 18408709 | |
| Microtubule assembly and organization | eIF-4a | Abnormal spindle, spindle poles splayed, increased number of cells in prometaphase | np | 18463163 | |
| Combinatorial effect with methyl methanesulphonate (2) | eIF-4a | Synthetic lethal with methyl methanesulphonate | sp | 19543366 | |
| Mutant human huntingtin aggregation | eIF-4a | Decreased mutant human huntingtin aggregation | <= -2 | 19789644 | |
| Muscle morphogenesis and function (1) | eIF-4a | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (1) | eIF-4a | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | eIF-4a | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Muscle morphogenesis and function (3) | eIF-4a | none | np | 20220848 | |
| Heat nociception (1) | eIF-4a | none | -0.62 | 21074052 | |
| Heart development and function (1) | eIF-4a | Larval lethal | 0.4 | 20371351 | |
| Serratia marcescens infection (1) | eIF-4a | none | 0.787878787878787 | 19520911 | |
| Notch pathway regulation (4) | eIF-4a | Completely lethal (pupal) | sp | 19363474 | |
| Notch pathway regulation (4) | eIF-4a | Completely lethal (before pupal) | sp | 19363474 | |
| Akt-TOR pathway negative feedback regulation | eIF-4a | Decreased dAkt phosphorylation after insulin stimulation | -2.8 | 10 min insulin stimulation | 20585550 |
| Adiposity regulation (1) | eIF-4a | none | -0.431 | 20074523 | |
| RTK-Ras-ERK pathway regulation (1) | eIF-4a | Decreased ERK phosphorylation after EGF stimulation | -6.56 | 10 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (1) | eIF-4a | Decreased ERK phosphorylation after EGF stimulation | -6.04 | 0 minutes EGF stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4a | none | 1.05 | 30 minutes sSpitz stimulation | 22028469 |
| RTK-Ras-ERK pathway regulation (2) | eIF-4a | Increased ERK phosphorylation after sSpitz and EGF stimulation | 1.86 | 10 minutes sSpitz stimulation | 22028469 |
