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Gene : tsr D. melanogaster

DB identifier  ? FBgn0011726 Secondary Identifier  ? CG4254
Name  ? twinstar Source  FlyBase
  • synonyms:
  • FBgn0011726,
  • D-cof,
  • 12/8,
  • l(2)k13409,
  • Tsr,
  • l(2)k03101,
  • cofilin/actin depolymerizing factor homolog,
  • Cofilin,
  • ADFcofilin,
  • FBgn0020539,
  • FBgn0020533,
  • Twinstar,
  • FBgn0022163,
  • actin-depolymerizing factor,
  • no terminal filament,
  • FBgn0011567,
  • ADF/cofilin,
  • FBgn0024209,
  • D61,
  • ntf,
  • Cadf,
  • CG4254,
  • l(2)03101,
  • T8,
  • twin star,
  • Cofilin/actin depolymerizing factor-like,
  • FBan0004254,
  • cofilin/ADF,
  • DCofilin,
  • l(2)k05633,
  • ADF

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49 Alleles

DB identifier Symbol Allele Class Organism
FBal0243246 tsr[LL01333]   Drosophila melanogaster
FBal0243247 tsr[LL02200]   Drosophila melanogaster
FBal0211821 tsr[CC01393]   Drosophila melanogaster
FBal0177374 tsr[DG24312]   Drosophila melanogaster
FBal0140903 tsr[ntf]   Drosophila melanogaster
FBal0177373 tsr[EY16043]   Drosophila melanogaster
FBal0257222 tsr[HMS00534]   Drosophila melanogaster
FBal0246826 tsr[Scer\UAS.cPa]   Drosophila melanogaster
FBal0158544 tsr[EY11205]   Drosophila melanogaster
FBal0177366 tsr[d05545]   Drosophila melanogaster
FBal0177365 tsr[f06853]   Drosophila melanogaster
FBal0177367 tsr[c05308]   Drosophila melanogaster
FBal0064471 tsr[k16304]   Drosophila melanogaster
FBal0064472 tsr[k12103]   Drosophila melanogaster
FBal0064473 tsr[k09317]   Drosophila melanogaster
FBal0064474 tsr[k05633]   Drosophila melanogaster
FBal0064475 tsr[k05419b]   Drosophila melanogaster
FBal0064476 tsr[k05403]   Drosophila melanogaster
FBal0064477 tsr[k01208]   Drosophila melanogaster
FBal0064478 tsr[k00508]   Drosophila melanogaster
FBal0044408 tsr[1]   Drosophila melanogaster
FBal0044409 tsr[2]   Drosophila melanogaster
FBal0061266 tsr[k13409]   Drosophila melanogaster
FBal0061272 tsr[k03101]   Drosophila melanogaster
FBal0259717 tsr[KK108706]   Drosophila melanogaster
FBal0060856 tsr[+t6.4]   Drosophila melanogaster
FBal0088557 tsr[unspecified]   Drosophila melanogaster
FBal0261823 tsr[CPTI002237]   Drosophila melanogaster
FBal0177372 tsr[N121] loss of function allele Drosophila melanogaster
FBal0101124 tsr[00026]   Drosophila melanogaster

322 Clones

Secondary Identifier DB identifier
bs45a10 FBcl0049507
EC00447 FBcl0062695
EC39580 FBcl0062725
EC22976 FBcl0064521
EC34271 FBcl0064525
EC01805 FBcl0064529
EC30506 FBcl0064547
EC15107 FBcl0064573
EC01582 FBcl0064575
EC14028 FBcl0064583
EC00847 FBcl0064591
EC14810 FBcl0064593
EC22207 FBcl0064603
EC30807 FBcl0064611
EC40678 FBcl0064621
EC30420 FBcl0064625
EC27978 FBcl0064629
EC13105 FBcl0064815
EN11426 FBcl0093461
EN04406 FBcl0093535
EN08252 FBcl0093717
EN01843 FBcl0093719
EN02918 FBcl0093725
EN01762 FBcl0093729
EN07031 FBcl0093731
EN12062 FBcl0093733
EN09609 FBcl0093745
EN12164 FBcl0093747
EN03863 FBcl0093749
EN07940 FBcl0093753

4 Exons

DB identifier Symbol
FBgn0011726:4 tsr:4
FBgn0011726:3 tsr:3
FBgn0011726:2 tsr:2
FBgn0011726:1 tsr:1

1 Transcripts

DB identifier Gene
FBtr0072188 tsr

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0072188-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0072188-3-prime-utr Drosophila melanogaster

Interactions

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3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
37841 NCBI Entrez Gene identifiers FBgn0011726
40852 NCBI Entrez Gene identifiers FBgn0011726
63422 BioGRID FBgn0011726

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 10305.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 10508.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 9843.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 8146.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 11550.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 5749.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 7621.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 10286.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 13225.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 11026.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 9290.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 10928.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 10070.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 11556.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 13825.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 11024.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 11308.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 9653.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 9627.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 7841.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 10578.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 6723.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 7250.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 5466.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 4941.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 9970.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 9537.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 8683.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 6906.0
FBgn0011726 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 6431.0

3 Introns

DB identifier
Organism . Name
intron_FBgn0011726:4_FBgn0011726:3 Drosophila melanogaster
intron_FBgn0011726:3_FBgn0011726:2 Drosophila melanogaster
intron_FBgn0011726:2_FBgn0011726:1 Drosophila melanogaster

18 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage tsr Increased lipid droplet area 2.021423616   19067489
Lipid storage tsr Increased lipid droplet area 2.849818393   19067489
Cell morphology tsr Morphology np   14527345
Actin morphology tsr Cytokinesis failure np   12975351
Cytokinesis tsr Multi-nucleate cells np   15380073
Cytokinesis regulation tsr Binucleate cells medium   15547975
Intracellular Listeria monocytogenes infection tsr Decreased GFP protein expression strong   16020693
Mycobacterial infection (1) - M. fortuitum infection tsr Decreased M. fortuitum intracellular infection 4.9 measurement after 3 days 16020694
Mycobacterial infection (2) - E. coli phagocytosis tsr Decreased E. coli phagocytosis np   16020694
Constitutive protein secretion and Golgi organization (1) tsr Decreased horseradish peroxidase protein expression sp   16452979
Constitutive protein secretion and Golgi organization (2) tsr Aggregated and swollen Golgi membranes np   16452979
C. trachomatis infection tsr C. trachomatis infection down np   18369471
S2 cell spreading tsr Increased actin protein expression at cell perimeter on Con A surface sp   21041442
RTK-Ras-ERK pathway regulation (1) tsr none 1.05 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) tsr none -0.34 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) tsr Increased ERK phosphorylation after sSpitz and EGF stimulation 2.4 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) tsr Increased ERK phosphorylation after sSpitz and EGF stimulation 2.6 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation tsr none -0.01   23263283

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