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Gene : Dref D. melanogaster
DB identifier  ? FBgn0015664 Secondary Identifier  ? CG5838
Name  ? DNA replication-related element factor Source  FlyBase
  • synonyms:
  • Dmel_DREF,
  • DRE (DNA replication-related element) binding factor,
  • DRE-binding factor,
  • DmDREF,
  • DNA-replication-related element factor,
  • p80,
  • DNA replication-related element-binding factor,
  • dDREF,
  • DNA replication-related element binding factor,
  • p80/DREF,
  • FBan0005838,
  • CG5838,
  • FBgn0015664,
  • DNA,
  • replication-related element-binding factor,
  • DREF,
  • FBgn0010077,
  • CG5838-PA,
  • CG5838-RA
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Lists
This Gene is in 2 lists:
Fly classI (1496)
Fly classIb (585)

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24 Alleles

DB identifier Symbol Allele Class Organism
FBal0266232 Dref[GL00532]   Drosophila melanogaster
FBal0141845 Dref[dsRNA.1-212]   Drosophila melanogaster
FBal0148067 Dref[dsRNA.1-723]   Drosophila melanogaster
FBal0258684 Dref[GMR.PH]   Drosophila melanogaster
FBal0211919 Dref[CB02226]   Drosophila melanogaster
FBal0131252 Dref[EP460]   Drosophila melanogaster
FBal0148066 Dref[KG09294]   Drosophila melanogaster
FBal0197919 Dref[dsRNA.h-h.Scer\UAS]   Drosophila melanogaster
FBal0197920 Dref[dsRNA.t-t.Scer\UAS]   Drosophila melanogaster
FBal0213095 Dref[dsRNA.Scer\UAS.cUa]   Drosophila melanogaster
FBal0141844 Dref[MtnA.PH]   Drosophila melanogaster
FBal0122283 Dref[Act5C.PL]   Drosophila melanogaster
FBal0244909 Dref[JF02232]   Drosophila melanogaster
FBal0263038 Dref[GLV21057]   Drosophila melanogaster
FBal0095819 Dref[CR1.Scer\UAS]   Drosophila melanogaster
FBal0095818 Dref[CR2.Scer\UAS]   Drosophila melanogaster
FBal0095817 Dref[CR3.Scer\UAS]   Drosophila melanogaster
FBal0059078 Dref[fl.Scer\UAS]   Drosophila melanogaster
FBal0093422 Dref[Scer\UAS.cSa]   Drosophila melanogaster
FBal0206900 Dref[GD11784]   Drosophila melanogaster
FBal0216869 Dref[dsRNA.Scer\UAS.cHa]   Drosophila melanogaster
FBal0288056 Dref[EP-108]   Drosophila melanogaster
FBal0222328 Dref[NP4719]   Drosophila melanogaster
FBal0274854 Dref[NIG.5838R]   Drosophila melanogaster

95 Clones

Secondary Identifier DB identifier
CK01.13C.A12 FBcl0404805
CK01.94C.F9 FBcl0404828
Dmel_dig_018879_0664_3545 FBcl0373579
Dmel_neb_007514_0931_2078 FBcl0373580
CK01.13D.A10 FBcl0404854
EK206957 FBcl0032186
EK149222 FBcl0032266
EK073721 FBcl0032284
EK163336 FBcl0032300
EK205603 FBcl0032320
EK106355 FBcl0032380
EK282241 FBcl0032398
EK115951 FBcl0032418
EK174364 FBcl0032666
EN13736 FBcl0095435
GH08947 FBcl0105625
GH06085 FBcl0105637
GH07412 FBcl0105647
GH20289 FBcl0105649
GM07662 FBcl0141223
LD05480 FBcl0152016
LD12445 FBcl0152024
LD16851 FBcl0152025
LD03169 FBcl0152027
LD06010 FBcl0152029
LD07163 FBcl0152030
LD11506 FBcl0152033
LD20865 FBcl0152035
LD11439 FBcl0152036
LD15284 FBcl0152037

5 Exons

DB identifier Symbol
FBgn0015664:5 Dref:5
FBgn0015664:4 Dref:4
FBgn0015664:3 Dref:3
FBgn0015664:1 Dref:1
FBgn0015664:2 Dref:2

2 Transcripts

DB identifier Gene
FBtr0310483 Dref
FBtr0079889 Dref

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0079889-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0310483-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0079889-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0310483-3-prime-utr Drosophila melanogaster

Interactions

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Other

0 Pathways

2 Cross References

Identifier
Source . Name
Subject . Primary Identifier
34328 NCBI Entrez Gene identifiers FBgn0015664
60422 BioGRID FBgn0015664

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier
Submission . Title
Cell Line . Name
Developmental Stage . Name 		Score
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 999.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1064.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 905.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 788.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 846.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 950.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 867.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 848.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 627.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1303.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 886.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 598.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 750.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 751.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1279.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 877.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 981.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 796.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1348.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 887.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 850.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1148.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 830.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 879.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 768.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1971.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2399.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1958.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1962.0
FBgn0015664 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1861.0

4 Introns

DB identifier
Organism . Name
intron_FBgn0015664:5_FBgn0015664:4 Drosophila melanogaster
intron_FBgn0015664:4_FBgn0015664:3 Drosophila melanogaster
intron_FBgn0015664:3_FBgn0015664:1 Drosophila melanogaster
intron_FBgn0015664:3_FBgn0015664:2 Drosophila melanogaster

33 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Dref none 0.732979193   19067489
Lipid storage Dref none 0.544001269   19067489
Hedgehog signaling Dref Increased Hedgehog reporter activity 6.48   16311596
Cell size and cell-cycle regulation (1) Dref none sp   16496002
Mitosis Dref Chromosome misalignment np   17412918
Combinatorial effect with methyl methanesulphonate (1) Dref none sp   19543366
Combinatorial effect with methyl methanesulphonate (2) Dref Synthetic lethal with methyl methanesulphonate sp   19543366
Muscle morphogenesis and function (1) Dref Lethal np   20220848
Muscle morphogenesis and function (1) Dref Lethal np   20220848
Heart development and function (1) Dref none 1   20371351
Heart development and function (1) Dref none 1   20371351
Serratia marcescens infection (1) Dref none 0.305882352941176   19520911
Notch pathway regulation (4) Dref Completely lethal (pupal) sp   19363474
Notch pathway regulation (4) Dref Completely lethal (pupal) sp   19363474
PGN-induced dJNK phosphorylation Dref Increased P-JNK protein expression with PGN 3.47 15 min PGN induction 19893628
Hh pathway regulation Dref Upregulation of Hh pathway 0.818609731894844   17903264
Hh pathway regulation Dref Upregulation of Hh pathway 1.13067744041448   17903264
Self-renewal and differentiation in neural stem cells Dref GFP aggregates number, GFP aggregates size, neuroblast less large cells, neuroblast cell shape, ganglion mother cell shorter lineages, neuroblast loss, neuroblast loss with unchanged neuroblast cell size, neuroblast underproliferation, lethal sp   21549331
Adiposity regulation (1) Dref none -0.104   20074523
Blood cell homeostasis regulation (1) Dref Increased melanotic mass formation np   20540764
Blood cell homeostasis regulation (2) Dref none np   20540764
Blood cell homeostasis regulation (3) Dref Increased melanotic mass formation 13.6   20540764
Blood cell homeostasis regulation (4) Dref none 2.5   20540764
Blood cell homeostasis regulation (5) Dref Increased melanotic mass formation 100   20540764
Blood cell homeostasis regulation (6) Dref Increased melanotic mass formation 17.4   20540764
Blood cell homeostasis regulation (7) Dref Increased melanotic mass formation 15.4   20540764
Blood cell homeostasis regulation (8) Dref Increased melanotic mass formation 100   20540764
RTK-Ras-ERK pathway regulation (1) Dref Decreased ERK phosphorylation after EGF stimulation -4.34 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Dref none -0.6 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Dref none 0.11 30 minutes sSpitz stimulation 22028469

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